Search results for "R1"
showing 10 items of 1016 documents
A Computational Study on Temperature Variations in MRgFUS Treatments Using PRF Thermometry Techniques and Optical Probes
2021
Structural and metabolic imaging are fundamental for diagnosis, treatment and follow-up in oncology. Beyond the well-established diagnostic imaging applications, ultrasounds are currently emerging in the clinical practice as a noninvasive technology for therapy. Indeed, the sound waves can be used to increase the temperature inside the target solid tumors, leading to apoptosis or necrosis of neoplastic tissues. The Magnetic resonance-guided focused ultrasound surgery (MRgFUS) technology represents a valid application of this ultrasound property, mainly used in oncology and neurology. In this paper
Secondary Stroke Prevention in Polish Adults: Results from the LIPIDOGRAM2015 Study
2021
Background: The purpose of the study was to evaluate secondary stroke prevention in Poland and its association with sociodemographic factors, place of residence, and concomitant cardiovascular risk factors. Material and methods: From all patients in LIPIDOGRAM2015 Study (n = 13,724), 268 subjects had a history of ischaemic stroke and were included. Results: 165 subjects (61.6%) used at least one preventive medication. Oral antiplatelet and anticoagulation agents were used by 116 (43.3%) and 70 (26.1%) patients, respectively. Only 157 (58.6%) participants used lipid-lowering drugs, and 205 (76.5%) were treated with antihypertensive drugs. Coronary heart disease (CHD) and dyslipidaemia were a…
Control de plagas y desarrollo institucional en la estación de Patología Vegetal de Burjassot (Valencia)
2006
The Estación de Patología Vegetal de Burjassot (Valencia), created in 1924, carried out important activities related to the control of pests, in varied fronts as original research, adaptation of techniques, and popularization. The biological control was highly practiced, and it was centered on orange pests. The chemical control of pests was also developed in this center.
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…
La desigualdad económica regional en América Latina (1895-2010)
2020
En este artículo se analiza por primera vez el crecimiento y la evolución de la desigualdad regional a lo largo del proceso de desarrollo económico de nueve países de Latinoamérica (Argentina, Bolivia, Brasil, Chile, Colombia, México, Perú, Uruguay y Venezuela) entre 1895 y 2010. Para ello, en primer lugar se verifica la presencia de un proceso de beta-convergencia entre los países latinoamericanos para la totalidad del periodo. No obstante, se muestra cómo este proceso fue especialmente intenso durante los periodos en los que los diferentes Estados implementaron políticas activas de desarrollo (ISI) que favorecieron la convergencia entre las regiones de un mismo país. En segundo lugar, se …
Combined Therapy of Interferon Plus Ribavirin Promotes Multiple Adaptive Solutions in Hepatitis C Virus
2009
Hepatitis C virus (HCV) presents several regions involved potentially in evading antiviral treatment and host immune system. Two regions, known as PKR-BD and V3 domains, have been proposed to be involved in resistance to interferon. Additionally, hypervariable regions in the envelope E2 glycoprotein are also good candidates to participate in evasion from the immune system. In this study, we have used a cohort of 22 non-responder patients to combined therapy (interferon alpha-2a plus ribavirin) for which samples obtained just before initiation of therapy and after 6 or/and 12 months of treatment were available. A range of 25-100 clones per patient, genome region and time sample were obtained…
New scenarios for neuronal structural plasticity in non-neurogenic brain parenchyma: the case of cortical layer II immature neurons
2011
The mammalian central nervous system, due to its interaction with the environment, must be endowed with plasticity. Conversely, the nervous tissue must be substantially static to ensure connectional invariability. Structural plasticity can be viewed as a compromise between these requirements. In adult mammals, brain structural plasticity is strongly reduced with respect to other animal groups in the phylogenetic tree. It persists under different forms, which mainly consist of remodeling of neuronal shape and connectivity, and, to a lesser extent, the production of new neurons. Adult neurogenesis is mainly restricted within two neurogenic niches, yet some gliogenic and neurogenic processes a…
"R1_SP vs. centrality (LHC10h)" of "Global polarization of $\Lambda$ and $\overline{\Lambda}$ hyperons in Pb-Pb collisions at the LHC"
2021
The correction $R_{\mathrm{SP}}^{(1)}$ for finite resolution of the spectator plane angle $\Psi_{\mathrm{SP}}$ as a function of collision centrality for LHC10h data set.
"R1_SP vs. centrality (LHC11h)" of "Global polarization of $\Lambda$ and $\overline{\Lambda}$ hyperons in Pb-Pb collisions at the LHC"
2021
The correction $R_{\mathrm{SP}}^{(1)}$ for finite resolution of the spectator plane angle $\Psi_{\mathrm{SP}}$ as a function of collision centrality for LHC11h data set.
"R1_SP vs. centrality (LHC15h)" of "Global polarization of $\Lambda$ and $\overline{\Lambda}$ hyperons in Pb-Pb collisions at the LHC"
2021
The correction $R_{\mathrm{SP}}^{(1)}$ for finite resolution of the spectator plane angle $\Psi_{\mathrm{SP}}$ as a function of collision centrality for LHC15h data set.