Search results for "R1"
showing 10 items of 1016 documents
Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains
2020
Zymomonas mobilis is the most efficient bacterial ethanol producer and its physiology is potentially applicable to industrial-scale bioethanol production. However, compared to other industrially important microorganisms, the Z. mobilis metabolome and adaptation to various nutritional and genetic perturbations have been poorly characterized. For rational metabolic engineering, it is essential to understand how central metabolism and intracellular redox balance are maintained in Z. mobilis under various conditions. In this study, we applied quantitative mass spectrometry-based metabolomics to explore how glucose-fed non-growing Z. mobilis Zm6 cells metabolically adapt to change of oxygen avai…
Croissance endogène et espace
1997
International audience
Defining gut mycobiota for wild animals: a need for caution in assigning authentic resident fungal taxa
2021
Animal gut mycobiota, the community of fungi that reside within the gastrointestinal tract, make an important contribution to host health. Accordingly, there is an emerging interest to quantify the gut mycobiota of wild animals. However, many studies of wild animal gut mycobiota do not distinguish between the fungi that likely can reside within animal gastrointestinal tracts from the fungal taxa that are non-residents, such as macrofungi, lichens or plant symbionts/pathogens that can be ingested as part of the host’s diet. Confounding the non-resident and resident gut fungi may obscure attempts to identify processes associated with the authentic, resident gut mycobiota per se. To redress th…
Chemically Stressed Bacterial Communities in Anaerobic Digesters Exhibit Resilience and Ecological Flexibility
2020
Anaerobic digestion is a technology known for its potential in terms of methane production. During the digestion process, multiple metabolites of high value are synthesized. However, recent works have demonstrated the high robustness and resilience of the involved microbiomes; these attributes make it difficult to manipulate them in such a way that a specific metabolite is predominantly produced. Therefore, an exact understanding of the manipulability of anaerobic microbiomes may open up a treasure box for bio-based industries. In the present work, the effect of nalidixic acid, γ-aminobutyric acid (GABA), and sodium phosphate on the microbiome of digested sewage sludge from a water treatmen…
Simulating multilevel dynamics of antimicrobial resistance in a membrane computing model
2019
Membrane computing is a bio-inspired computing paradigm whose devices are the so-called membrane systems or P systems. The P system designed in this work reproduces complex biological landscapes in the computer world. It uses nested “membrane-surrounded entities” able to divide, propagate, and die; to be transferred into other membranes; to exchange informative material according to flexible rules; and to mutate and be selected by external agents. This allows the exploration of hierarchical interactive dynamics resulting from the probabilistic interaction of genes (phenotypes), clones, species, hosts, environments, and antibiotic challenges. Our model facilitates analysis of several aspects…
Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders
2021
New analogs of the commercial asymmetric monomethine cyanine dyes thiazole orange (TO) and thiazole orange homodimer (TOTO) with hydroxypropyl functionality were synthesized and their properties in the presence of different nucleic acids were studied. The novel compounds showed strong, micromolar and submicromolar affinities to all examined DNA ds-polynucleotides and poly rA–poly rU. The compounds studied showed selectivity towards GC-DNA base pairs over AT-DNA, which included both binding affinity and a strong fluorescence response. CD titrations showed aggregation along the polynucleotide with well-defined supramolecular chirality. The single dipyridinium-bridged dimer showed intercalatio…
Aperiodicity in finitely generated bi-ideals and bounded bi-ideals
2014
Disertācijā pētīts aperiodiskums divu vienpusēji bezgalīgu vārdu klašu – galīgi ģenerētu biideālu un ierobežotu bi-ideālu – kontekstā. Gan galīgi ģenerētus bi-ideālus, gan ierobežotus biideālus ir ērti uzdot, izmantojot bāzes virkni. Ierobežotu bi-ideālu gadījumā tiek nofiksēta galīga vārdu kopa, no kuras tiek uzģenerēta bāzes virkne. Savukārt galīgi ģenerētu bi-ideālu gadījumā bāzes virkne ir periodiska, līdz ar to var uzskatīt, ka ir dota galīga bāze. Efektīvā ģenerēšana un zināmie aperiodiskuma nosacījumi kalpo par motivāciju apskatīt galīgi ģenerētu bi-ideālu potenciālo pielietojumu kriptogrāfijā – aperiodisku gadījuma skaitļu ģenerēšanā. Savukārt, ierobežoti bi-ideāli ir galīgi ģenerēt…
Hyväksytty ja kielletty aviollinen väkivalta 1600- luvun loppupuolen itäsuomalaisissa maaseutuyhteisöissä
2008
Artikkelissa tarkastellaan miesten vaimoihinsa kohdistamaa väkivaltaa itäsuomalaisella maaseudulla kulttuurisesta näkökulmasta. Keskeisiä kysymyksiä ovat väkivallan hyväksyttävyys sekä yhteisön reaktiot väkivaltaan. Näiden teemojen perusteella tarkastellaan myös vaimon asemaa suhteessa mieheensä sekä sukupuolten välistä suhdetta ylipäänsä. Aineistona käytetään kihlakunnanoikeuksien puhtaaksikirjoitettuja pöytäkirjoja. Nämä yksittäisten ihmisten elämänkohtalot toimivat esimerkkeinä varhaismodernissa kulttuurissa yleisemmin jaetuista avioliittoa ja puolisoiden välistä suhdetta koskevista näkemyksistä ja suhtautumistavoista. Kietäväinen-Sirénin mukaan miehen vaimoaan kohtaan harjoittama väkiva…
Cooperation between Different CRISPR-Cas Types Enables Adaptation in an RNA-Targeting System
2021
CRISPR-Cas systems are immune systems that protect bacteria and archaea against their viruses, bacteriophages. Immunity is achieved through the acquisition of short DNA fragments from the viral invader’s genome.
”Jag var slö och slapp och somnade nu lite varstans” : förvandling som narrativ i diagnosberättelser om diabetes typ 1
2018
I artikeln belyses hur individer upplever sjukdom och diagnos genom personliga erfarenhetsberättelser om diabetes typ 1. Med artikeln strävas efter att besvara frågorna: Hur berättar personer med diabetes typ 1 om att insjukna i diabetes? Vad karaktäriserar en diagnosberättelse? I analysen av berättelserna tas avstamp i medicinsociologen Arthur Franks teori om tre typer av narrativ (återgångsberättelser, kaosberättelser och utforskande berättelser). En definition av begreppet diagnosberättelse presenteras och diskuteras. Materialet består av sex berättelser. Intervjupersonerna är tre kvinnor och tre män i olika åldrar. Syftet med artikeln är att pröva den narrativa teorin kring sjukdomstill…