Search results for "RACE"
showing 10 items of 4458 documents
C1q–Ha matrix regulates the local synthesis of hyaluronan in malignant pleural mesothelioma by modulating has3 expression
2021
Increased hyaluronic acid (HA) production is often associated with cancer progression. In malignant pleural mesothelioma (MPM), HA is found at elevated levels in pleural effusions and sera of patients, and it has been widely debated whether MPM cells are able to produce HA by themselves or through the release of growth factors stimulating other cells. Another key component of the MPM microenvironment is C1q, which can act as a pro-tumorigenic factor favoring cell adhesion, migration and proliferation. The aim of the current study was to prove that MPM primary cells are able to synthesize HA and to inquire the stimulus given by C1q&ndash
Chemical-physical parameters, major, minor and trace elements composition of thermo-mineral groundwaters of Greece
2022
This dataset comprises samples of thermo-mineral waters collected by the same team over the period from October 2004 to March 2020 and analysed in the same laboratory. Samples were collected on the whole territory of Greece.
Molecular Pathways Implicated in Radioresistance of Glioblastoma Multiforme: What Is the Role of Extracellular Vesicles?
2023
Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to treatment, and characterized by a high degree of anaplasia and proliferation. Routine treatment includes ablative surgery, chemotherapy, and radiotherapy. However, GMB rapidly relapses and develops radioresistance. Here, we briefly review the mechanisms underpinning radioresistance and discuss research to stop it and install anti-tumor defenses. Factors that participate in radioresistance are varied and include stem cells, tumor heterogeneity, tumor microenvironment, hypoxia, metabolic reprogramming, the chaperone system, non-coding RNAs, DNA repair, and extracellular vesicles (EVs). We direct our a…
Televīzijas satura personalizētu ieteikumu sistēmas izstrāde
2022
Mūsdienu cilvēkam ir pieejams ļoti plašs televīzijas satura piedāvājums. Līdz ar to daudz laika tiek pavadīts nevis skatoties interesējošu filmu vai raidījumu, bet meklējot piemērotu saturu. Ieteikumu sistēmas mērķis ir ieteikt cilvēkam potenciāli saistošu produktu vai pakalpojumu, sašaurinot pieejamo pakalpojumu un produktu klāstu, atvieglojot izvēli un piedāvājot cilvēkam to, ko cilvēks visticamāk vēlētos redzēt vai pirkt. Darba mērķis ir izveidot interaktīvās televīzijas satura ieteikumu sistēmu, ar kuras palīdzību katram pakalpojuma lietotājam tiktu aprēķināti individuāli satura ieteikumi. Aprēķini balstītos uz SIA Tet televīzijas klientu skatīšanās paradumiem, kur tiktu izmantoti pieej…
Rompé tus barreras: Un análisis sobre el uso del coaching ontológico en la plataforma de entrenamiento de Nike en Buenos Aires
2020
In recent times, coaching has become relevant in heterogeneous discourses and practices in the economic, political and cultural fields of contemporary societies. Based on our ethnographic analysis of different training sessions on the Nike+ Run Club platform in Buenos Aires, in this article we study how ontological coaching operates in the field of sport and races. Then, we ask about how people who attend this platform appropriate coaching techniques to manage emotions, moods, and body effects according to the business entrepreneurship logic. Through this work, the ethnographic results are articulated with a reflection about the theory, practice, and values of the ontological coaching, wher…
Singēna ortotopiska prostatas audzēja modeļa izveide imūnkompetentās pelēs vēža šūnu producēto ekstracelulāro vezikulu pato-fizioloģiskās lomas pētīj…
2018
Prostatas vēzis vēl joprojām ir nozīmīga veselības problēma visā pasaulē un ir parādīts ka ekstracelulārās vezikulas (EV) ir nozīmīgs faktors ļaundabīga audzēja attīstībā. Šī darba gaitā tika izveidots singēns ortotopisks prostatas audzēja modelis C57BL/6 tipa pelēs vēža šūnu producēto EV patofizioloģiskās lomas pētījumiem in vivo. Iegūtie dati liecina par mikrometastāžu veidošanos aknās un ar kuņģi asociētajās audu struktūrās pelēs ar ortotopisku audzēju, kurā veiktas intratumorālas metastātisko TRAMP-C2 šūnu hipoksijā producēto EV injekcijas, bet ne citu grupu dzīvniekiem, kas norāda uz modeļa potenciālu tālākiem EV pētījumiem. Tomēr nepieciešams ieviest izmaiņas, kas dotu iespēju turpmāk…
Air Quality Assessment by the Determination of Trace Elements in Lichens (Xanthoria calcicola) in an Industrial Area (Sicily, Italy)
2022
This study provides data on variation in the content of metals and metalloids measured in the lichens (Xanthoria calcicola Oxner) collected in the Syracusan petrochemical complex (Sicily, Italy) which is considered one of the largest in Europe. Concentrations of eighteen trace elements measured in the lichens that were collected from 49 different points were analyzed using an inductively coupled plasma (ICP-MS) device. The concentrations of the typical elements of industrial emissions (As, Cr, Ni, and V) highlight the environmental criticality that exists in the study area. The interpretation of the data in terms of multi-element statistical analysis (FA) and enrichment factor (EFs) proved …
Acylative Dynamic Kinetic Resolution of Secondary Alcohols: Tandem Catalysis by HyperBTM and Bäckvall's Ruthenium Complex.
2021
Non-enzymatic dynamic kinetic resolution (DKR) of secondary alcohols by enantioselective acylation using an isothiourea-derived HyperBTM catalyst and racemization of slowly reacting alcohol by Backvall's ruthenium complex is reported. The DKR approach features high enantioselectivities (up to 99:1), employs easy-to-handle crystalline 4-nitrophenyl isobutyrate as the acylating reagent, and proceeds at room temperature and under an ambient atmosphere. The stereoinduction model featuring cation-π system interactions between the acylated HyperBTM catalyst and π electrons of an alcohol aryl subunit has been elaborated by DFT calculations.
Structural Origin of Metal Specificity in Isatin Hydrolase from Labrenzia aggregata Investigated by Computer Simulations.
2017
We performed quantum-chemical calculations, ab initio molecular dynamics, hybrid quantum mechanics/molecular mechanics (QM/MM) and enhanced sampling metadynamics simulations to investigate the origin of metal specificity in isatin hydrolase from Labrenzia aggregata. The peculiar octahedral binding geometry of the Mn2+ ion in the Michaelis complex includes both the isatin substrate and the catalytic water within the first coordination shell of the cation. Our calculations show that the same arrangement of the ligands cannot be efficiently achieved in the presence of other small divalent metal cations such as Zn2+ or Cu2+ . On the contrary, bulkier alkaline-earth cations such as Mg2+ , which …
Correlations of blood selenium with hematological parameters in West German adults.
1988
The serum selenium and the whole blood selenium of 72 healthy persons (47 women, 25 men) was determined. There exist sex specific differences of the whole blood selenium between men (98 +/- 19 micrograms Se/L) and women (89 +/- 17 micrograms Se/L). The serum selenium did not show sex specific differences, but sex specific differences are found if the total amount of extracellular selenium is calculated by correction of the serum selenium with the hematocrit. Women have more extra-cellular selenium/L whole blood (40 +/- 8 micrograms Se) than men (36 +/- 7 micrograms Se). Men have more intraerythrocyte selenium (cellular selenium = 67 +/- 14 micrograms Se) in one L whole blood than women (52 …