Search results for "RAM"
showing 10 items of 35643 documents
La dimensión cívica de las artes
2002
Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Moll…
2011
Since sponges, as typical filter-feeders, are exposed to a high load of attacking prokaryotic and eukaryotic organisms, they are armed with a wide arsenal of antimicrobial/cytostatic low-molecular-weight, non-proteinaceous bioactive compounds. Here we present the first sponge agent belonging to the group of ASABF-type antimicrobial peptides. The ASABF gene was identified and cloned from the demospongeSuberites domuncula. The mature peptide, with a length of 64 aa residues has a predicted pI of 9.24, and comprises the characteristic CSαβ structural motif. Consequently, the S. domuncula ASABF shares high similarity with the nematode ASABFs ; it is distantly related to the defensins. The recom…
Direct Reprogramming of Somatic Cells into Induced Neuronal Cells: Where We Are and Where We Want to Go
2014
Direct reprogramming of somatic cells has emerged as a novel strategy to generate neurons, including those of human origin. The method provides enormous potential for studying the mechanisms directing neuronal differentiation, the modeling of neurodegenerative diseases, and the development of potential novel approaches for brain repair. In this chapter, we briefly trace the history of reprogramming, as well as the strategies employed to date for converting different types of somatic cells, including fibroblasts, hepatocytes, astrocytes, and pericytes into induced neuronal cells of different subtype identity. Reprogramming involves particular emphasis on transcriptional and posttranscription…
Objektu-relāciju kartēšanas rīku salīdzinājums ASP.NET ietvarā
2021
ORM rīki ir populāra izvēle ASP.NET lietotnes loģiskā slāņa savienošanai ar datubāzi. Tomēr jauniem izstrādātājiem ne vienmēr var būt skaidrs un zināms, kādu ORM rīku izmantot lietotnes realizācijā. “Bakalaura” darba galvenais mērķis ir izpētīt ASP.NET ORM rīku piedāvājumu un veikt savstarpēju salīdzināšanu autora izvēlētā ORM rīku izlasē. Darbā tiek izprasts, kas ir objektorientēta kartēšana, kādus ORM rīkus piedāvā ASP.NET ietvars, un tiek veikts izvēlētu ORM rīku praktisks salīdzinājums. Lai veiktu praktisku salīdzinājumu, tika izveidota ASP.NET lietotne, datubāze un vaicājumi, kas katram ORM rīkam ir jāizpilda. Praktiskā pētījuma rezultātā ir formulēti secinājumi par katru ORM rīku, ana…
Tiešsaistes labdarības sistēma
2017
„Tiešsaistes labdarības sistēma” ir sistēma, ar kuras palīdzību cilvēki spēs uzzināt un apskatīt dažādus labdarības pasākumus, kuri ir plānoti tuvāka laikā. Cilvēki spēs pieteikties izvēlētiem pasākumiem, piedalīties tajos un lejupielādēt bildes, ja vēlās. Galvenais uzdevums ir izveidot strādājošu sistēmu, kura spētu lietotājiem nodrošināt dažādas funkcijas. Savu aktualitāti sistēma gūst, jo atvieglo labdarības pasākumu reklamēšanu, kā arī cilvēku piesaistīšanu un statistikas veidošanu. Darbā aprakstītas ne vien konkrētas sistēmas funkcionālās un nefunkcionālās prasības, norādīts kādas tabulas veidot datu uzglabāšanai, bet arī ir apskatāms kā jāizskatās lietotāja saskarnei. Sistēma ir izvei…
Latvijas Vēstures Institūta Žurnāls. 2010, Nr. 1 (74)
2010
Valsts Kultūrkapitāla fonds
Genetic organization of the citCDEF locus and identification of mae and clyR genes from Leuconostoc mesenteroides.
1999
ABSTRACT In this paper, we describe two open reading frames coding for a NAD-dependent malic enzyme ( mae ) and a putative regulatory protein ( clyR ) found in the upstream region of citCDEFG of Leuconostoc mesenteroides subsp. cremoris 195. The transcriptional analysis of the citrate lyase locus revealed one polycistronic mRNA covering the mae and citCDEF genes. This transcript was detected only on RNA prepared from cells grown in the presence of citrate. Primer extension experiments suggest that clyR and the citrate lyase operon are expressed from a bidirectional A-T-rich promoter region located between mae and clyR.
Acid sensitivity of neomycin-resistant mutants ofOenococcus oeni: a relationship between reduction of ATPase activity and lack of malolactic activity
1999
Mutants of Oenococcus oeni were isolated as spontaneous neomycin-resistant mutants. Three of these mutants harbored a significantly reduced ATPase activity that represented 50% of that of the wild-type strain. Their growth rates were also impaired at pH 5.3 (46-86% of the wild-type level). However, the profiles of sugar consumption appeared identical to those of the parental strain. At pH 3.2, all the mutant strains failed to grow and a drastic decrease in viability was observed after an acid shock. Surprisingly, all the isolated mutants were devoid of malolactic activity. These results suggest that the ATPase and malolactic activities of O. oeni are linked to each other and play a crucial …
A melanocortin 1 receptor (MC1R) gene polymorphism is useful for authentication of Massese sheep dairy products
2011
Massese is an Italian sheep breed, with black or grey coat colour, mainly reared in the Tuscany and Emilia Romagna regions. Recently, the emerging interests in this breed have resulted in the production of Pecorino cheese obtained with only Massese milk. In order to be profitable, this marketing link between Massese breed and its products should be defended against fraudsters who could include milk of other sheep breeds or cow milk in Massese labelled productions. To identify the genetic factors affecting coat colour in sheep, we have recently analysed the melanocortin 1 receptor (MC1R) gene and identified several single nucleotide polymorphisms (SNPs). In this work, as a first step to set …
Kirkko harjulla : Alvar Aallon suunnitteleman Muuramen kirkon (1926-29) alkuperäinen interiööri ja sen kokemat muutostyöt
2010
Arkkitehti Alvar Aalto sai suunniteltavakseen Muuramen kirkon vuonna 1926.Tämä klassisistinen kirkko on pohjois-eteläsuuntaan sijoitettu yksilaivainen valkoiseksi rapattu pitkäkirkko, joka kohoaa kylätaajamassa kahden järven välisellä Muuratharjulla. Kirkon pohjoisjulkisivua hallitsee pääsisäänkäyntiä korostava pyörökaarisyvennys, jonka muoto toistuu kirkon eteläistä julkisivua hallitsevan puolipyöreän apsidin muodossa. Rakennuksen itäsivulla nousee korkea ja kapea campanile-tyylinen kellotorni. Länsipuolen julkisivua hallitsee runkohuoneeseen nähden poikittain sijoitettu seurakuntasali, jonka alaosa avautuu pieneksi arkadikaariston kehystämäksi loggiaksi. Sen edessä oli alun perin kirkkota…