Search results for "RAM"
showing 10 items of 35643 documents
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Healthy mistrust or complacent confidence? : Civic vigilance in the reporting by leading newspapers on nuclear waste disposal in Finland and France
2021
Trust and confidence have been identified as crucial for efforts at solving the conundrum of high-level radioactive waste management (RWM). However, mistrust has its virtues, especially in the form of “civic vigilance”—healthy suspicion towards the powers that be. This article examines civic vigilance in the form of “watchdog journalism,” as practiced by the leading Finnish and French newspapers—Helsingin Sanomat (HS) and Le Monde (LM)—in their RWM reporting. Although both countries are forerunners in RWM, Finland constitutes a Nordic “high-trust society” while France has been characterized as a “society of mistrust.” Employing the methods of frame analysis, key RWM-related news frames were…
Voices from the past: memory and desire in Marina Warner’s radio play Brigit’s Cell
2020
This article examines Marina Warner’s radio play Birgitta’s Cell (BBC Radio 4), later published as Brigit’s Cell (2010) focusing on the themes of memory and desire. By drawing on Jan Assman’s theories on collective memory, the article shows how the two time levels Warner builds in the radio drama succeed in creating a fresh connection between women in the past and in the present as well as between individual and collective experience. The analysis of Warner’s work focuses on the dramatization of the story, taking into account the results offered by the use of the spoken word, fragments of dialogues, interior monologues, silences, enhanced, by its initial destination for the radio.
Using Talking Books to Support Early Reading Development
2009
This chapter explores the question of how interactive multimedia talking books can promote young children’s literacy development. Whilst commercially available talking books can motivate young children to read, there is little evidence that they are linked to the development of skills known to promote reading itself. The ‘Bangers and Mash’ talking books (Chera, 2000), were designed to address this issue, and we review studies that evaluated their effectiveness as classroom resources that could promote reading-related skills and abilities. We then consider the various barriers to collaborative learning in Early Years classrooms, and describe how resources like talking books could address som…
Radzenes biomehānisko parametru izmaiņas pēc kroslinkinga pacientiem ar keratokonusu
2019
Ievads: Pateicoties mūsdienu tehnoloģijām iespējams noteikt radzenes biomehāniskos parametrus, kurus klīniski var pielietot daudziem mērķiem. Piemēram, tādējādi iespējams diagnosticēt radzenes ektātiskās slimības jau to agrīnajās stadijās, proti, pirms parādās klīniskie simptomi un izmaiņas topogrāfijā, tostarp uzraudzīt slimības gaitu, izvērtēt terapijas efektivitāti, kā arī izvairīties no keratektāzijas pēc refraktīvās ķirurģijas. Pētījuma mērķis: Noteikt radzenes biomehāniskos parametrus keratokonusa pacientiem pirms un pēc radzenes kolagēna-kroslinkinga (CXL) 12 mēnešu periodā, pamatojoties uz Corvis ST (OCULUS Optikgeräte GmbH, Vācija) ierīces datiem. Balstoties uz iegūtajiem datiem, i…
Raman analysis of insulin denaturation induced by high-pressure and thermal treatments
2012
Raman spectroscopy has been used to investigate different conformational states of bovine pancreatic insulin: the native form and several structurally modified states with different extent of denaturation induced by thermo-chemical treatment and by applying very high pressure (up to 8 GPa) using a diamond anvil cell. High-pressure results confirm the peculiar strength to volume compression of insulin and largely extend the pressure range of its structural stability (0-4.2 GPa). Above 4.2 GPa, insulin undergoes an irreversible structural transition that, once pressure is released, leaves the sample in a new conformational state. The protein secondary structure after the pressure treatment re…
Strongly Coupled Coherent Phonons in Single-Layer MoS 2
2019
We present a transient absorption setup combining broadband detection over the visible-UV range with high temporal resolution ($\sim$20fs) which is ideally suited to trigger and detect vibrational coherences in different classes of materials. We generate and detect coherent phonons (CPs) in single layer (1L) MoS$_2$, as a representative semiconducting 1L-transition metal dichalcogenide (TMD), where the confined dynamical interaction between excitons and phonons is unexplored. The coherent oscillatory motion of the out-of-plane $A'_{1}$ phonons, triggered by the ultrashort laser pulses, dynamically modulates the excitonic resonances on a timescale of few tens fs. We observe an enhancement by…
Melleņu rametu struktūras raksturojums dažādās mežaudzēs
2016
Bakalaura darbs – ‘’Melleņu rametu struktūras raksturojums dažādās mežaudzēs’’ izstrādāts laika posmā no 2014. gada augusta līdz 2016. gada maijam Latvijas Universitātes, Bioloģijas fakultātes, Botānikas un ekoloģijas katedrā un Latvijas Valsts mežzinātnes institūtā ‘’Silava’’. Darbā izmantoti Lindas Robaltes maģistra darba laikā ievāktie melleņu rametu struktūru dati (vecums, diametrs un augstums) (Robalte 2014). Par pētījuma vietu izvēlētas divas dažādas teritorijas – dabas liegums ‘’Gruzdovas meži’’ vecāko apzināto egļu dēļ (~ 273 gadi) un Slīteres nacionālā parka teritorija, jo arī tajā koki sasnieguši līdzīgu vecumu, bet tajā ir tipiskāki augšanas apstākļi mellenēm. Katrā no teritorijā…
Parastās mellenes Vaccinium myrtillus (L.) rametu vecuma un izmēru struktūras salīdzinājums dažāda vecuma mētrāju audzēs Slīteres nacionālā parka ter…
2018
Mellene ir sīkkrūmu suga, kas ir viena no biežāk sastopamajām zemsedzes veģetācijas sugām boreālo mežu ekosistēmās, tomēr tā netiek pietiekami novērtēta. Mellene pozitīvi ietekmē bioloģisko daudzveidību, un tās klātbūtne ir viens no rādītājiem par mežu augšanas apstākļu bagātināšanos. Līdzīgi kā kokiem arī mellenes gadskārtas sniedz informāciju par apstākļiem konkrētajā teritorijā, taču par īsāku laika periodu. Par pētījuma vietu izvēlēts Slīteres nacionālais parks un tā apkārtne, jo tajā pārstāvēti dažāda vecuma mētrāji, kā arī tādēļ, ka noteiktā Slīteres nacionālā parka teritorijā iepriekš veidojies degums. Šajā teritorijā kopumā izveidots 21 parauglaukums (10 x 10m). Seši parauglaukumi i…
Earth Bricks with Halloysite Nanoclay: Research and Experimentation for the Sustainability of Materials
2021
The paper illustrates the experimentation activities on rammed earth and nanotechnologies conducted by the authors. The experimental research was carried out with the aim of improving the performance of rammed earth bricks with clay nanotubes, creating a ‘new material’ with reduced embodied energy and low CO2 emissions into the atmosphere. Specifically, the analysed performances are related to the compressive strength that expand their area of use as a building material.