Search results for "RATES"
showing 10 items of 1636 documents
Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages
2009
Objective— Cholesteryl ester transfer protein (CETP) is a target gene for the liver X receptor (LXR). The aim of this study was to further explore this regulation in the monocyte-macrophage lineage and its modulation by lipid loading and inflammation, which are key steps in the process of atherogenesis. Methods and Results— Exposure of bone marrow–derived macrophages from human CETP transgenic mice to the T0901317 LXR agonist increased CETP, PLTP, and ABCA1 mRNA levels. T0901317 also markedly increased CETP mRNA levels and CETP production in human differentiated macrophages, whereas it had no effect on CETP expression in human peripheral blood monocytes. In inflammatory mouse and human mac…
Cadmium, Copper and Tributyltin effects on fertilization of Paracentrotus lividus (Echinodermata)
2009
Marine environments are continuously being threatened by a large number of xenobi- otics from anthropogenic sources. The effect of chemical pollution on living organisms are numerous and may impair reproductive success of adults species of marine invertebrate and vertebrate through effects on gamete quality. Echinoderms are characterized by external fertilizzation and gametes, free of any type of protection, may be in contact with toxic substances so the reproductive success depends largely on the environment conditions. The purpose of this work is to assess the effects on the in vitro fertiliza- tion of exposure of sea urchin Paracentrotus lividus gametes to xenobiotic substances as CuSO4,…
Książę Niccola Machiavellego jako przykład zastosowania toposu zakulisowości
2019
Aby wyjaśnić fenomen popularności Księcia Niccola Machiavellego, należy wskazać na osobliwy sposób komunikowania się autora tego dzieła z czytelnikiem. Autor przedstawia siebie jako fachowca z dziedziny sztuki politycznej, za swoich czytelników zaś chce mieć jedynie tych, którzy, jak on, znają się na rzeczy. Charakterystyczny zimny i, z pozoru przynajmniej, nieozdobny styl, jakim posługuje się autor Księcia, podkreśla dodatkowo profesjonalny i nieosobisty stosunek pisarza do przedmiotu jego rozważań. W kategoriach teorii retorycznej taki sposób komunikowania się daje się opisać jako poszukiwanie okrężnych dróg do tego, co Kenneth Burke określał mianem konsubstancjacji retorycznej. Mówca sta…
The Chinese Postman Problem with Load-Dependent Costs
2018
[EN] We introduce an interesting variant of the well-known Chinese postman problem (CPP). While in the CPP the cost of traversing an edge is a constant (equal to its length), in the variant we present here the cost of traversing an edge depends on its length and on the weight of the vehicle at the moment it is traversed. This problem is inspired by the perspective of minimizing pollution in transportation, since the amount of pollution emitted by a vehicle not only depends on the travel distance but also on its load, among other factors. We define the problem, study its computational complexity, provide two mathematical programming formulations, and propose two metaheuristics for its soluti…
Another "French paradox": explaining why interest rates to microenterprises dit not increase with the change in French usury legislation
2015
Conventional wisdom indicates that the growth of credit may not materialize if credit rates remain capped by usury laws, as had long been the case in France. France therefore abolished usury ceilings on loans to microenterprise in an effort to increase financing for microentrepreneurs. This should have led to an increase in interest rates and increase in microcredit. However, we do not find any increase in interest rates and this is therefore a paradox. The paper provides a brief literature review and the salient features of the legislative changes in France. It follows this up with a presentation of interest rate movements. The discussion of possible explanations of the paradox includes cl…
Critical appraisal of tubular putative eumetazoans from the Ediacaran Weng'an Doushantuo biota
2015
Molecular clock analyses estimate that crown-group animals began diversifying hundreds of millions of years before the start of the Cambrian period. However, the fossil record has not yielded unequivocal evidence for animals during this interval. Some of the most promising candidates for Precambrian animals occur in the Weng'an biota of South China, including a suite of tubular fossils assigned to Sinocyclocyclicus, Ramitubus, Crassitubus and Quadratitubus, that have been interpreted as soft-bodied eumetazoans comparable to tabulate corals. Here, we present new insights into the anatomy, original composition and phylogenetic affinities of these taxa based on data from synchrotron radiation …
Molecular characterization of Treponema pallidum subsp. pallidum in Switzerland and France with a new multilocus sequence typing scheme
2018
Syphilis is an important public health problem and an increasing incidence has been noted in recent years. Characterization of strain diversity through molecular data plays a critical role in the epidemiological understanding of this re-emergence. We here propose a new high-resolution multilocus sequence typing (MLST) scheme for Treponema pallidum subsp. pallidum (TPA). We analyzed 30 complete and draft TPA genomes obtained directly from clinical samples or from rabbit propagated strains to identify suitable typing loci and tested the new scheme on 120 clinical samples collected in Switzerland and France. Our analyses yielded three loci with high discriminatory power: TP0136, TP0548, and TP…
Nonlinear Raman Spectroscopy in Gases
1992
0022-2860; Recent progress in high-resolution non-linear coherent Raman spectroscopy in the gas phase is reviewed. An instrumental spectral resolution of less than 100 MHz can be routinely achieved. It is limited by the convoluted linewidths of the lasers used for excitation and is of particular advantage in the gas phase, where the rotational structure of vibrational bands is to be resolved. It also allows the measurement of linewidths and line positions with an accuracy of 60 MHz when an appropriate wavemeter is used for calibration. After a short overview of the various techniques being used, examples of recent results of the evaluation of measurements on nitrogen, oxygen, carbon dioxide…
NO donors. Part 16: investigations on structure-activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent…
2007
The vasoactive properties of 14 organic mononitrates were investigated in vitro using PGF(2alpha)-precontracted porcine pulmonary arteries. A surprisingly wide range of vasorelaxant potencies was observed (pD(2): 3.36-7.50). Activities showed to be highly sensitive to the molecular structure and the substituents at the molecular carrier of the nitrate group. A correlation between lipophilicity and vasorelaxant potency could not be recognized. 2-Nitrooxyethylammoniumnitrate (1) was found to be slightly superior to the high potency trinitrate GTN.