Search results for "RCA"
showing 10 items of 3171 documents
Reforma laboral y desregulación del mercado de trabajo
2017
Cuando se cumplen cinco años de su imposición unilateral por el gobierno conservador, el balance de la reforma laboral contradice en la práctica los objetivos retóricos con los que se pretendió justificarla (creación de empleo de calidad, flexibilidad interna como alternativa a los despidos, adaptabilidad de las relaciones laborales) y pone de manifiesto la agenda oculta de sus promotores políticos y empresariales (precariedad contractual, devaluación salarial, debilitamiento de la negociación colectiva, aumento de la desigualdad). El presente artículo trata de evaluar el impacto de la reforma en la desregulación de las relaciones laborales, con especial referencia al empleo, la negociación…
De la ley de barrios al diseño de políticas locales de empleo
2009
(Erm) de Manlleu, localidad de la provincia de Barcelona. La investigación forma parte de un conjunto de acciones integradas llevadas a cabo en el Erm a partir de la aplicación de la denominada Ley de Barrios, impulsada por el Gobierno catalán. La Ley facilita el desarrollo de actuaciones en el ámbito local, especialmente en el terreno urbanístico. Pero, como mostraremos, puede ser también un instrumento eficaz para desarrollar políticas de promoción del empleo ligadas al territorio. Un tipo de políticas que remite a la importancia que viene adquiriendo el ámbito local en cuestiones de empleo; y que se refleja en los numerosos estudios que se realizan en torno a la idea del desarrollo local…
Prognostic factors of overall survival for patients with FIGO stage IIIc or IVa ovarian cancer treated with neo-adjuvant chemotherapy followed by int…
2020
International audience; Introduction The aim of this study was to identify prognostic factors of overall survival in patients with FIGO stage IIIc or IVa ovarian cancer (OC) treated by neo-adjuvant chemotherapy (NAC) followed by interval debulking surgery.Materials and methods Data from 483 patients with ovarian cancer were retrospectively collected, from January 1, 2000 to December 31, 2016, from the FRANCOGYN database, regrouping data from 11 centers specialized in ovarian cancer treatment. Median overall survival was determined using the Kaplan-Meier method. Univariate and multivariate analysis were performed to define prognostic factors of overall survival.Results The median overall sur…
The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila.
2006
International audience; In Drosophila, evolutionarily conserved transcription factors are required for the specification of neural lineages along the anteroposterior and dorsoventral axes, such as Hox genes for anteroposterior and columnar genes for dorsoventral patterning. In this report, we analyse the role of the columnar patterning gene ventral nervous system defective (vnd) in embryonic brain development. Expression of vnd is observed in specific subsets of cells in all brain neuromeres. Loss-of-function analysis focussed on the tritocerebrum shows that inactivation of vnd results in regionalized axonal patterning defects, which are comparable with the brain phenotype caused by mutatio…
Investigating the Role of Guanosine on Human Neuroblastoma Cell Differentiation and the Underlying Molecular Mechanisms
2021
Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy. Here, we evaluated whether guanosine (GUO), a natural purine nucleoside, which is able to induce differentiation of many cell types, may cause the differentiation of human neuroblastoma SH-SY5Y cells and the molecular mechanisms involved. We found that GUO, added to the cell culture medium, promoted neuron-like cell differentiation in a time- and concentration-dependent manner. This effect was mainly due to an extracellular GUO action since nucleoside transporter inhibitors r…
Búsqueda de nuevos biomarcadores con utilidad pronóstica en el Neuroblastoma
2016
El neuroblastoma (NB) es un tumor neuroectodérmico de las células embrionarias derivadas de la cresta neural. Constituye el tumor sólido extracraneal más frecuente en la infancia y es altamente heterogéneo en su comportamiento clínico y biológico. Los pacientes considerados de alto riesgo presentan tasas de supervivencia a los 5 años que no superan el 40% en la mayoría de las series estudiadas pese a recibir un tratamiento multimodal de gran intensidad. El resto de pacientes no incluidos en esta categoría son un grupo muy diverso en cuanto a presentación clínica, edad y características moleculares, expuestos a ser sobretratados o infratratados si la asignación de riesgo no está bien definid…
Experimental study of Morris-Lecar neuron : design, coupling and interpretation
2015
We present in this manuscript an experimental electronic neuron based on complete Morris-Lecar model without simplifications, able to become an experimental unit tool to study collective association of robust coupled neurons. The circuit design is given in details according to the ionic currents of this model. The experimental results are compared with the theoretical prediction, leading to a good agreement between them, which therefore validates the circuit. We present the different areas according to the bifurcation control parameters, the membrane capacitance and the excitation current. We have highlighted the behavior of the neuron for each parameters zone. A coupling of such neurons is…
Hybrid Magnetic Multilayers by Intercalation of Cu(II) Phthalocyanine in LDH Hosts
2012
The intrinsic flexibility of layered double hydroxides (LDHs) has been here exploited to design hybrid multilayered materials by intercalation of the copper phthalocyaninetetrasulfonate (CuPcTs) complex in the interlamellar space offered by these layered hosts through a simple anion-exchange procedure. Taking advantage of their chemical versatility, two different LDHs, the diamagnetic ZnAl and the ferromagnetic NiAl, have been synthesized and characterized to explore the differences in the magnetic properties of the hybrids introduced by the intercalation of the paramagnetic complex.
Nuovo realismo e metodi di ricerca misti
2014
Il nuovo realismo ha evidenziato i limiti del costruttivismo sociale e del cosiddetto «pensiero debole», che rischia di sfociare nel nichilismo. Sono stati recentemente rimossi dei pregiudizi che impedivano di cogliere la realtà dei fatti educativi nella sua concreta evidenza. Tuttavia un’apertura alla prospettiva metafisica offrirebbe al nuovo realismo ulteriori spazi epistemologici. In tale senso il contributo del realismo critico potrebbe aiutare a superare l’artificiosa antinomia tra il ruolo attivo del soggetto conoscente e la rilevazione oggettiva dei fatti educativi. Se si realizzasse questa apertura la conoscenza scientifica e la conoscenza corrente non sarebbero più viste come anti…
Do conservative agriculture practices increase soil water repellency? A case study in citrus-cropped soils
2012
Water repellency is a property of soils that inhibits or delays infiltration. Long-term conservation practices as no-tillage, manure addition, application of herbicides may contribute to increase soil organic matter and, hence, soil water repellency. In this research, we have studied the effect of long-term addition of plant residues and organic manure, no-tillage and no chemical fertilization (MNT), annual addition of plant residues and no-tillage (NT), application of conventional herbicides and no-tillage (H), and conventional tillage (CT) on soil water repellency in Mediterranean calcareous citrus-cropped soils (Eastern Spain). Slight water repellency was observed in MNT soils, which may…