Search results for "REGENERATION"
showing 10 items of 889 documents
No more Masterplan: the Cityforming Protocol
2018
In Europe, the season of urban regeneration has produced important effects both in the review of the urban devices and in the rethinking of the settlement forms and their spatial and human relations. But it cannot be denied that certain diseases emerged which often have anaesthetised – if not cancelled – the regenerative effects envisaged. The urban transition, while it has increased the use of regeneration processes from the bottom, has at the same time extended the epidemic of failures derived from a top-down approach. The critical issues of hierarchical urban regeneration cannot be solved by revising the procedures for participation, improving design devices, or innovating implementation…
Il Paradigma della Città Fluida
2013
Nella recente crisi globale i poderosi flussi di capitali finanziari, sociali e relazionali che hanno alimentato la riqualificazione urbana nel corso degli ultimi quindici anni non sono più disponibili ad essere intercettati in maniera indiscriminata così come è stato possibile fino a qualche anno fa. Nell'era della crisi strutturale le città più dinamiche non sono più quelle in grado di attrarre progetti urbani iconici ed investitori spinti dal mercato immobiliare o dalla redditività delle attività ricreative, ma quelle città che, a partire dalle loro profonde e diversificate risorse culturali, saranno capaci di attuare una vera e propria “metamorfosi” per usarle come base per la creazione…
Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regeneration
2015
International audience; Members of the TGF-β superfamily transduce their signals through type I and II receptor serine/threonine kinases. The binding of activins to activin type IIA (ActRIIA) or type IIB (ActRIIB) receptors induces the recruitment and phosphorylation of an activin type I receptor (ALK4 and/or ALK7), which then phosphorylates the Smad2 and Smad3 intracellular signaling proteins. The regulation of members of the TGF-β family is known to be complex, because many proteins able to bind the ligands and inhibit their activities have been identified. Growth and differentiation factor 11 (Gdf11) belongs to the TGF-β family. GDF11, like other members of the TGF-β superfamily, is prod…
The lizard cerebral cortex as a model to study neuronal regeneration
2002
The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex…
Enhancing Urban Brownfield Regeneration to Pursue Sustainable Community Outcomes through Dynamic Performance Governance
2019
This paper discusses the case of Puerto Madero (Buenos Aires, Argentina) to illustrate how the “Dynamic Performance Governance” framework is able to support policy networks to pursue sustainable community outcomes in urban brownfield regeneration. The case is an example of successful implementation of urban renewal carried out through a significant involvement of the private sector. It portrays a “financially-driven” governance mode which entails balancing the advantage of cash flow reinvestment for public services and infrastructure capacity development, with potential shortcomings in terms of social inclusion. Findings reveal two main trade-offs associated with policy design and implement…
Modification of xenogenic bone substitute materials - effects on the early healing cascadein vitro
2013
Introduction Initial platelet activation with subsequent cytokine release at the defect site plays a crucial role in tissue integration. The aim of this study was to evaluate the influence of topographic and biomimetic collagen modifications of a xenogenic bone substitute material (BSM) on in vitro platelet activation and cytokine release. Material and Methods Three types of xenogenic BSM were used. Two BSM with different levels of granularity (large granule BSM [XBSM/L], small granule BSM [XBSM/S]) and a BSM with collagen (XBSM/C). All three samples were incubated with platelet concentrate of four healthy volunteers at room temperature for 15 min. For all groups, highly thrombogenic collag…
Cutting-edge progress and challenges in stimuli responsive hydrogel microenvironment for success in tissue engineering today.
2020
The field of tissue engineering has numerous potential for modified therapeutic results and has been inspired by enhancements in bioengineering at the recent decades. The techniques of regenerating tissues and assembling functional paradigms that are responsible for repairing, maintaining, and revitalizing lost organs and tissues have affected the entire spectrum of health care studies. Strategies to combine bioactive molecules, biocompatible materials and cells are important for progressing the renewal of damaged tissues. Hydrogels have been utilized as one of the most popular cell substrate/carrier in tissue engineering since previous decades, respect to their potential to retain a 3D str…
PAESAGGI IN TRASFORMAZIONE: LA RIGENERAZIONE DEL BACINO MINERARIO DEL NORD PAS DE CALAIS L’iscrizione Unesco e la costruzione della strategia generale
2017
L’attività mineraria, al pari di un evento sismico, rappresenta per il territorio una ferita difficile da rimarginare. I luoghi coinvolti assistono al radicale mutamento dei loro paesaggi, alla trasformazione della loro geografia, alla rottura degli equilibri che per secoli avevano sostenuto la loro economia e società. Questa condizione si aggrava ancor di più a seguito della dismissione delle attività, quando il sistema economico della monocoltura mineraria non costituisce più una risorsa e al suolo rimangono i segni di ciò che era stata l’industria estrattiva. I resti fisici dell’attività industriale iniziano, però, dopo alcuni anni, a esercitare un senso di fascinazione sulla stessa soci…
A modified surgical approach for hard and soft tissue reconstruction of severe periimplantitis defects – Laser‐assisted periimplant defect regenerati…
2019
Strategies targeting fibrosis in pulmonary disease
2006
Pulmonary fibrosis is potentially a curable disease, but this potential is dependent on correct identification of disease targets at the research stage. While invaluable work has been done in animal models to identify factors involved in the initiation of fibrogenesis, we must now shift our focus towards identifying factors involved in the chronic progression of fibrosis and how to modulate the progressive nature of the disease towards repair or regeneration of non-functioning pulmonary tissue.