Search results for "REGION"

Interplay of three G‑quadruplex units in the KIT promoter

2019

The proto-oncogene KIT encodes for a tyrosine kinase receptor, which is a clinically validated target for treating gastrointestinal stromal tumors. The KIT promoter contains a G-rich domain within a relatively long sequence potentially able to form three adjacent G-quadruplex (G4) units, namely, K2, SP, and K1. These G4 domains have been studied mainly as single quadruplex units derived from short truncated sequences and are currently considered promising targets for anticancer drugs, alternatively to the encoded protein. Nevertheless, the information reported so far does not contemplate the interplay between those neighboring G4s in the context of the whole promoter, possibly thwarting dru…

Structure and Evolution of a European Parliament via a Network and Correlation Analysis

2016

We present a study of the network of relationships among elected members of the Finnish parliament, based on a quantitative analysis of initiative co-signatures, and its evolution over 16 years. To understand the structure of the parliament, we constructed a statistically validated network of members, based on the similarity between the patterns of initiatives they signed. We looked for communities within the network and characterized them in terms of members’ attributes, such as electoral district and party. To gain insight on the nested structure of communities, we constructed a hierarchical tree of members from the correlation matrix. Afterwards, we studied parliament dynamics yearly, wi…

Prevalence of dangerous alcohol consumption in nursing students

2020

BACKGROUND: The use of alcohol is a phenomenon widely spread among young people and takes on different psychological, sociological and cultural connotations. The aim of the study is to stimulate the prevalence of dangerous alcohol consumption and examine the associated factors in a cohort of nursing students from the University of Palermo. METHODS: The study employed a cross-sectional study design. On March 2020, a survey was provided to all nursing students of University of Palermo of the three years of course who attend daily lessons. The questionnaire was structured into two parts. The first section investigates on socio-demographic information. In the second part of the survey, the Alco…

Luigi Sturzo e l'Autonomia

2011

The relationship between interdisciplinarity and distinct modes of university-industry interaction

2019

Abstract Interdisciplinary research (IDR) has raised increasing expectations among scholars and policymakers about its potential to produce ground-breaking scientific contributions and satisfy societal demands. While existing research highlights that novel connections across fields is beneficial for scientific contributions with high academic impact, comparatively less is known about whether IDR is positively associated to scientists’ engagement with non-academic actors. To investigate this, we examine whether there is a systematic relationship between scientists’ IDR-orientation and their interactions with industry. We conceptually distinguish four stylized modes of interaction (firm creat…

First morphogenetic analysis of parasite eggs from Schistosomiasis haematobium infected sub-Saharan migrants in Spain and proposal for a new standard…

2021

International audience; Schistosomiasis is a Neglected Tropical Disease caused by trematode species of the genus Schistosoma. Both, autochthonous and imported cases of urogenital schistosomiasis have been described in Europe. The present study focuses on eggs, considered pure S. haematobium by genetic characterisation (intergenic ITS region of the rDNA and cox1 mtDNA). A phenotypic characterisation of S. haematobium eggs was made by morphometric comparison with experimental populations of S. bovis and S. mansoni, to help in the diagnosis of S. haematobium populations infecting sub-Saharan migrants in Spain. Analyses were made by Computer Image Analysis System (CIAS) applied on the basis of …

Regional heterogeneity in the business environment: the case of Italy

2022

How do we evaluate the business environment of regional economies? This paper makes use of primary data from the World Bank’s Subnational Doing Business studies to analyze the capacity of Italian regions to facilitate entrepre- neurs in setting up and operating new businesses. By comparing data across locations and over time, we are able to identify best practices that may help policy makers in the implementation of reforms aiming at improving the business environ- ment of Italian regions and, as a result, of the country.

On the Reaction of 3-Bromo-2-nitrobenzo[b]thiophene 13C-Labeled at C-2 with 3-(Trifluoromethyl)aniline:  A Preliminary Insight into a Nucleophilic Su…

1997

The results of the title reaction have furnished proofs against a rearrangement of the carbon-atom skeleton and for a nitro group shift in the relevant nucleophilic substitution.

In-Between ‘Smart’ Urban Growth and ‘Sluggish’ Rural Development? Reframing Population Dynamics in Greece, 1940–2019

2020

Multifaceted demographic dynamics have shaped population growth in Mediterranean Europe, reflecting a metropolitan cycle from urbanization to re-urbanization. To assess the distinctive impact of economic downturns on population dynamics, the present study illustrates the results of an exploratory analysis that assesses urban expansion and rural decline at various temporal scales in Greece, a peripheral country in southeastern Europe. Statistical analysis based on multivariate exploratory techniques outlined the persistent increase of regional populations, evidencing the distinctive role of agglomeration/scale with urbanization and early suburbanization phases (1940&ndash

Changes in the Intra-Metropolitan Location of Producer Services in Ile-de-France (1978-1997) : do information technologies promote a more dispersed s…

2003

Because of their intensive need for face-to-face contacts, producer services have, historically, been found at the core o f CBDs. However, it has been suggested that advances in information technologies could lead to the erosion o f the CBD’s economic base, rendering face-to-face contacts obsolete and enabling producer services to suburbanize. Although a considerable amount o f empirical work has been done on the suburbanization o f these activities in North-America, the same is not true of France. In this paper, we adopt an original methodology to study the role played by face-to-face contacts in the spatial distribution of producer services in the Ile-de-France region between 1978 and 199…