Search results for "REGION"

An initial comparative map of copy number variations in the goat (Capra hircus) genome

2010

Abstract Background The goat (Capra hircus) represents one of the most important farm animal species. It is reared in all continents with an estimated world population of about 800 million of animals. Despite its importance, studies on the goat genome are still in their infancy compared to those in other farm animal species. Comparative mapping between cattle and goat showed only a few rearrangements in agreement with the similarity of chromosome banding. We carried out a cross species cattle-goat array comparative genome hybridization (aCGH) experiment in order to identify copy number variations (CNVs) in the goat genome analysing animals of different breeds (Saanen, Camosciata delle Alpi,…

An ecological model of bridging the digital divide in education: A case study of OLPC deployment in Nepal

2018

The need for internships and school practices as a method of bridging the gap between education and industry in Romania

2017

Abstract This paper presents the current situation of school practice and internships as ways of reducing the gap between the labor market and education. In the first part, there is highlighted the current situation of Romania comparing with other European countries when it comes about graduates finding a job in their field of studies. Among the biggest issues encountered by a young graduate we see that "Lack of experience” play a big role in not finding a proper job in our country after graduation. So the need to reduce this problem is vital in order to ease finding a job in the studies areas for graduates. A list of advantages is presented to encourage internships/school practice among th…

Empty Urbanism: the bursting of the Spanish housing bubble

2015

The depth of the Spanish housing crisis manifests itself in the collapse of construction activity and in the amount of housing and land stocks. The geography of the crisis shows its widespread nature, and the intensity of the previous bubble explains spatial differences. Resulting from this collapse are some problematic areas of 'empty urbanism'. An enormous land bubble, emerging from the peculiar Spanish urban development model, was a key factor in the impacts - caused by the crisis - on the territory and land-use plans. The crisis has demonstrated the unsustainability of this and the urgency of change in the existing land-use plans.

Demographic Analysis of Bucharest-Ilfov Region

2013

Abstract This paper aims to achieve a study was to research, analyze and interpret statistical data, in conjunction with theoretical aspects that allowed assessment of regional information on population structure in the Bucharest-Ilfov. Bucharest-Ilfov region's population (2,264,865 inhabitants in 2012) is distributed inversely proportional to the size of two administrative entities (Bucharest - the capital of Romania - Ilfov county). Bucharest is the largest urban agglomeration in Romania, its population being 1,924,299 inhabitants, representing about 85% population of the region, more than 16.4% of the urban population of the country, or around 9% of the total population of Romania and ha…

L’autonomia di spesa delle Regioni fra Stato ed Unione europea dalla l. cost. 3/2001 alle condizionalità europee sulla ripresa e la resilienza

2021

L'articolo ricostruisce la tendenza all’accentramento nel governo delle finanze pubbliche e l’eccessiva distanza fra testo costituzionale e diritto costituzionale vivente per analizzare l'attuazione del Recovery Plan (PNRR) rilevando un ulteriore tendenza all’accentramento del governo della spesa. Si indagano dunque le ragioni della compressione dell’autonomia finanziaria di spesa per effetto del principio di indifferenza e del “doppio intreccio federale”. Si mira a inquadrare il tema alla luce della leale collaborazione e dellala resilienza istituzionale per accorciare la “distanza” fra testo costituzionale ed attuazione costituzionale in tema di autonomia di spesa delle Regioni. Si prospe…

Decomposing regional business change at plant level in Italy. A novel spatial shift-share approach

2014

Executive remuneration determinants: New evidence from meta-analysis

2019

This meta-analysis takes stock of 121 C.E.O. pay studies published between 1998 and 2018 with the objective of identifying the main drivers of C.E.O. pay from a global perspective and contributing to the agency vs managerial debate on this ground. The meta-results disclose a positive C.E.O. pay–performance correlation (the highest correlation coefficient corresponds to Earnings per share with a 34%) as the agency theory prescribes and the governance policies promote. However, firm size still predominates as the main driver of C.E.O. pay (correlation coefficient is around 44%) according to managerial premises. Moreover, our results reconcile both approaches because results of the meta-regres…

CTCF and BORIS Regulate Rb2/p130 Gene Transcription: A Novel Mechanism and a New Paradigm for Understanding the Biology of Lung Cancer

2011

Abstract Although innumerable investigations regarding the biology of lung cancer have been carried out, many aspects thereof remain to be addressed, including the role played by the retinoblastoma-related protein Rb2/p130 during the evolution of this disease. Here we report novel findings on the mechanisms that control Rb2/p130 gene expression in lung fibroblasts and characterize the effects of Rb2/p130 deregulation on the proliferative features of lung cancer cells. We revealed for the first time that in lung fibroblasts the expression of Rb2/p130 gene is directly controlled by the chromatin insulator CCCTC-binding factor, CTCF, which by binding to the Rb2/p130 gene promoter induces, and/…

Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification o…

2001

Abstract Appropriate regulation of IL-12 expression is critical for cell-mediated immune responses. In the present study, we have analyzed the regulation of IL-12 p40 promoter activity in primary human monocytes in vivo. Accordingly, we analyzed the p40 promoter by in vivo footprinting in resting and activated primary human blood CD14+ monocytes. Interestingly, footprints at binding sites for trans-activating proteins such as C/EBP, NF-κB, and ETS were only found upon stimulation with LPS and IFN-γ. In contrast, a footprint over a purine-rich sequence at −155, termed GA-12 (GATA sequence in the IL-12 promoter), was observed in resting, but not activated, cells. Further characterization of t…