Search results for "REPOSI"

Meta model of e-learning materials development

2014

The multitude of software tools is available for the creation of learning resources. However the majority of these tools provided by different software producers do not have a unified mechanism by means of which it would be possible to search and reuse the existing learning resources or their elements. To solve this problem the structures of descriptive data can be used. The aim of this paper is to describe a meta-model of e-learning objects and e-learning formats that could be used in the creation of e-learning materials compatible with various e-learning standards. The meta-data models that are used in widely-known learning resources’ repositories and their structure’s metadata standa…

In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection

2020

COVID-19 is a pandemic health emergency faced by the entire world. The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, and remdesivir (a nucleotide analogue used for Ebola infection). This work proposes a repurposing process using a database containing approximately 8000 known drugs in synergy structure- and ligand-based studies by means of the molecular docking and descriptor-based protocol. The proposed in silico findings identified new potential SARS CoV-2 main protease (MPRO) inhibitors that fit in the catalytic binding site of SARS CoV-2 MPRO. Several sel…

The Repurposing of Old Drugs or Unsuccessful Lead Compounds by in Silico Approaches: New Advances and Perspectives

2015

Have you a compound in your lab, which was not successful against the designed target, or a drug that is no more attractive? The drug repurposing represents the right way to reconsider them. It can be defined as the modern and rationale approach of the traditional methods adopted in drug discovery, based on the knowledge, insight and luck, alias known as serendipity. This repurposing approach can be applied both in silico and in wet. In this review we report the molecular modeling facilities that can be of huge support in the repurposing of drugs and/or unsuccessful lead compounds. In the last decades, different methods were proposed to help the scientists in drug design and in drug repurpo…

Identification of potential inhibitors targeting BRAF-V600E mutant melanoma cells.

2020

Valoda: nozīme un forma, 6: Valodas sistēma un lietojums

2015

Rakstu krājums „Valoda: nozīme un forma. 6. Valodas sistēma un lietojums” ir Latvijas Universitātes Humanitāro zinātņu fakultātes Latviešu un vispārīgās valodniecības katedras (sadarbībā ar Baltu valodniecības katedru) 2014. gada 20. un 21. martā rīkotās 50. profesora Artura Ozola dienas starptautiskās zinātniskās konferences „Vispārīgā valodniecība: valodas sistēma un lietojums” referātu apkopojums.

Hydro-Mechanical Behaviour of a Sand-Bentonite Mixture for the Confinement of Nuclear Wastes

2019

The established concept for the protection of the biosphere from high-level nuclear wastes consists in the use of multi-barrier systems in deep geological repository, for which clayey geomaterials are key elements. Bentonite-based materials are selected as buffer and backfilling materials. Once in place, the barriers will be subjected to a series of severe loadings, including strong variations of suction (i.e. wetting and drying cycles). The paper presents selected results from a large ongoing research work to investigate the behaviour of bentonite-based materials in the context of nuclear waste disposal. In particular, the paper focuses on the response of a Sand/Bentonite mixture under dif…

LU Bibliotēkas darbība Latvijas Universitātes e-resursu repozitārija izveidē

2011

Ziņojums seminārā „Institucionālais repozitārijs pētniecības attīstībai un zinātniskās informācijas pieejamībai”, kas sniegta starptautiskās Open Access nedēļas ietvaros (2011. gada 24. - 30. oktobris) sniedz ieskatu par institucionālo repozitāriju programmatūru, saturu, izveides gaitu.

Author Rights vs Self-Archiving in Spanish Scientific Journals

2013

AbstractThe paper analyzes publishers’ copyright policies and self-archiving conditions of Spanish scientific journals. Data are extracted from the directory DULCINEA that contains information of 1318 Spanish journals, of which 775 (61%) allow some form of self-archiving to be about 60% of the post-print version and allowing them 87% of the deposit of the version of record. In 72% of journals the deposit can be performed immediately after publication and in 16% after article acceptance. 72% of the journals are freely available without charge to the user this figure raises up to 86% if free access after an embargo is considered. Only 18% of the journals use Creative Commons licenses. The ado…

Når preposisjonar erstattar kasus : om preposisjonsobjekt (objektsadverbial) frå norrønt til moderne norsk

2006

Masteroppgave i Nordisk språk og litteratur 2006 - Høgskolen i Agder, Kristiansand Dette arbeidet har to hovuddelar. Den første delen er ei valensundersøking. Formålet med denne undersøkinga er å finne ut kva for valens verb som i moderne norsk krev preposisjonsobjekt, hadde på det norrøne språksteget. Den andre hovuddelen er ein analyse av preposisjonsobjekt i moderne norsk, med grunnlag i det teoretiske rammeverket i arbeidet, Lexicase Dependency Grammar (Starosta 1988). Sentrale prinsipp i Lexicase Dependency Grammar (LCDG) blir presenterte i kap. 2. I dette kapittel blir også metodiske spørsmål i samband med valensundersøkinga diskuterte, og korpusa som dannar grunnlag for undersøkingan…

Starting from the Origin: the Early Latin preposition de (and its companions)

2015

This paper explores the semantic network of the Early Latin preposition de (“from”) on the basis of an extensive investigation of the electronic corpus of Comedies by Plautus and Cato’s de Agricoltura, which represent a substantial sample of the oldest Latin attestations in an extensive and non-fragmentary form. Our approach is heavily based on Cognitive Grammar (Langacker 1987; 1991; Luraghi 2003), although we complement it with considerations on the use of prepositions in Latin elaborated in the framework of Functional Grammar (Pinkster 1990; 1991), as well as with arguments proposed in Linguistic Typology (Croft 1991). This approach allows an explicative account of the interconnections a…