Search results for "RICE"
showing 10 items of 2331 documents
Karyotype Abnormalities in a Variant Chinese Hamster Cell Line Resistant to Methyl Methanesulphonate
2004
A variant cell population, isolated from V79-CI 3 Chinese hamster cells after two consecutive treatments with methyl methanesulphonate (MMS), was found to be highly resistant to killing by this alkylating agent. The resistant cell line was cytogenetically characterized both by the presence of a stable translocation involving metacentric chromosome 2 and acrocentric chromosome 6 and by a supernumerary chromosome originated by the duplication of a small telocentric chromosome. This cell population also showed a transient transformed phenotype, seen as formation of transformed foci containing cells with high chromosomes counts and multiple chromosomal aberrations. As MMS-resistance and karyoty…
Kinetics of gamma-H2AX focus formation upon treatment of cells with UV light and alkylating agents.
2008
Histone H2AX is rapidly phosphorylated in response to DNA double-strand breaks (DSBs) induced by ionizing radiation (IR). Here we show that DNA damage induced by alkylating agents [methyl methanesulfonate (MMS) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)] and ultraviolet light (UV-C) leads to a dose and time dependent accumulation of phosphorylated H2AX (gamma-H2AX). Time course experiments revealed that the number of gamma-H2AX foci reached peak levels 8 hr after MMS or MNNG treatment and declined to almost control values within 24 hr after exposure. Upon UV-C treatment, a biphasic response was observed with a maximum 12 hr after treatment. In 43-3B cells deficient in nucleotide excisi…
Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents
1998
To elucidate mechanisms involved in alkylating drug resistance, Chinese hamster cells resistant to methylating agents have been generated upon transfection with human DNA. Here it is shown that these Chinese hamster ovary (CHO) variants exhibit the tolerance phenotype: they are alkyltransferase deficient (Mex-), cross-resistant to 6-thioguanine, exhibit reduced G-T binding (MutS alpha) activity and express the mismatch repair protein MSH2 at a significantly lower level than the corresponding control. By comparing wild-type cells with different tolerant strains that show gradual differences in resistance to methylating agents, it was shown that both the G-T binding activity and the amount of…
Amatrice: storia e storie di una comunità elastica
2020
Il contributo ricostruisce la storia del patrimonio gastronomico amaticiano: una storia di relazioni transcalari legate al lungo processo di emigrazione che nei secoli ha portato la comunità amatriciana a trasferirsi a Roma. Si ripercorre in che modo la comunità abbia costruito la tua tradizione gastronomica - intesa come patrimonio culturale, oltre che economico - nella relazione mobile tra più luoghi. Un processo di costruzione di simboli e capitali collettivi fortemente transcalare che affonda le radici nell'origine transumante della comunità amatriciana, di cui il volume nel complesso si occupa. Infine, facendo riferimento al presente post-sisma, il contributo discute criticamente il ru…
Hypertonic Stress and Amino Acid Deprivation Both Increase Expression of mRNA for Amino Acid Transport System A
2004
The activity of amino acid transport system A ([Oxender and Christensen, 1963][1]) is regulated in a variety of different ways, the best studied being the increases of its activity caused by starving cells of amino acids or by exposing them to hypertonicity (for review see [McGivan and Pastor-
The Global Boundary Stratotype Section and Point (GSSP) for the base of the Pliensbachian Stage (Lower Jurassic), Wine Haven, Yorkshire, UK
2006
14 pages; International audience; Following votes by the Pliensbachian Working Group, the Jurassic Subcommission and the International Commission on Stratigraphy, IUGS ratified the proposed Global Boundary Stratotype Section and Point (GSSP) for the base of the Pliensbachian Stage (Lower Jurassic) at the base of bed 73b in the Wine Haven section, Robin Hood's Bay, Yorkshire Coast, UK. This level contains the characteristic ammonite association Bifericeras donovani Dommergues and Meister and Apoderoceras sp. Complementary data include: a) Strontium-isotope stratigraphy, based on analysis of belemnites which yield a calcite 87Sr/86Sr ratio for the boundary level of 0.707425 and data supportin…
The Raven's Coloured Progressive Matrices in Healthy Children: A Qualitative Approach
2020
Studies on the structure of intelligence refer to two main theoretical models: the first one considers intelligence as a unitary construct, the second one assumes the involvement of a plurality of factors. Studies using Raven’s Coloured Progressive Matrices (RCPM) tasks have often highlighted the involvement of different cognitive abilities and brain structures, but in the clinical setting, RCPM measurement continues to be used as a single score. The current study aimed to analyse the RCPM performance following qualitative clustering, in order to provide an interpretation of the intelligence assessment through a factorial criterion. The RCPM have been administered to a large group of typica…
Real-time 3D movements analysis for a medical device intended for maintaining functional independence in aged adults at home
2016
We propose in this manuscript a realtime3D movement analysis system for inhomefunctionalabilities assessment in aged adults. As a first step, the purpose is to maintain the functionalindependence of this population and to allow an earlier detection of a motor decompensation inorder to facilitate a rehabilitation process. To quantify the equilibrium quality of a subject, webuilt a system using the Kinect sensor in order to analyze a simple clinical test validated in geriatricrehabilitation: the Timed Up and Go (TUG). Three experiments conducted in heterogeneousenvironments (laboratory, day hospital and home) showed good measurement reliability of theidentified parameters. In particular, they…
Vandalisme et art contemporain : action destructrice et/ou créatrice ? Un iconoclasme en Avignon : « Immersion (Piss Christ) » d’Andres Serrano
2014
National audience
«L’antico come principio di nuova architettura». Il tempo perenne delle opere e dei progetti
2022
Nonostante la raccolta degli scritti e dei progetti di Angelo Torricelli copra un arco temporale di oltre trent’anni (dal 1990 al 2021) essa costituisce una straordinaria narrazione coerente e coesa nella quale si ha chiara la sensazione di come l’oggetto della riflessione sia la connaturata dimensione sincronica dell’architettura tesa a essere, inevitabilmente, espressione di valori atemporali. Non a caso i titoli dei testi di Torricelli, ad iniziare da ciò che ne costituisce la sintesi suprema, l’espressione metonimica per eccellenza — "Il momento presente del passato" — tendono ad essere quasi dei voluti emblematici ossimori. Nella lettura interpretativa dell’antico in architettura propo…