Search results for "RIMI"
showing 10 items of 3981 documents
Comparative study to predict toxic modes of action of phenols from molecular structures.
2013
Quantitative structure-activity relationship models for the prediction of mode of toxic action (MOA) of 221 phenols to the ciliated protozoan Tetrahymena pyriformis using atom-based quadratic indices are reported. The phenols represent a variety of MOAs including polar narcotics, weak acid respiratory uncouplers, pro-electrophiles and soft electrophiles. Linear discriminant analysis (LDA), and four machine learning techniques (ML), namely k-nearest neighbours (k-NN), support vector machine (SVM), classification trees (CTs) and artificial neural networks (ANNs), have been used to develop several models with higher accuracies and predictive capabilities for distinguishing between four MOAs. M…
Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline
2009
Abstract A convenient synthesis of the pyrrolo[3,4- h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).
ChemInform Abstract: Synthesis of the New Ring System 6,8-Dihydro-5H-pyrrolo[3,4-h]quinazoline.
2009
Abstract A convenient synthesis of the pyrrolo[3,4- h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).
La antropología criminal y la novela naturalista
1896
B Res.061605
Sievietes militārajā dienestā: Dienējošu sieviešu pieredze vīriešu dominējošā vidē
2021
Militārā joma vēsturiski un sociāli tiek definēta kā tradicionāli vīrišķīga – tā ir, iespējams, viena no arhetipiski vīrišķīgākajām sociālajām struktūrām Rietumu sabiedrībā (Segal 1995). Taču militārajā dienestā un karadarbībā tik un tā sastopamas arī sievietes. Šajā bakalaura darbā pētīta 23 sieviešu pieredze, kuras visas dienē vai dienējušas Kanādas Bruņotajos spēkos (KBS) pēdējo četrdesmit gadu laikā. Šo sieviešu pieredze apkopota daļēji strukturētās intervijās, kas veiktas gan klātienē, gan rakstiskā formātā. Izmantojot Pjēra Burdjē teoriju par maskulīno dominanci un Reivinas Konelas koncepciju par maskulīno hegemoniju, darbā esmu pētījusi, kā sievietes pieredz militāro vidi caur dzimtē…
DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).
2009
Abstract The impact of DNA damage-induced replication blockage for early activation of stress kinases [stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK)] is largely unknown. Here, we show that induction of dual phosphorylation of SAPK/JNK by the DNA polymerase inhibitor aphidicolin was not ameliorated by additional exposure to ultraviolet (UV) light, indicating that overlapping mechanisms participate in signaling to SAPK/JNK triggered by both agents. UV-induced DNA replication blockage, cyclobutane pyrimidine dimer formation and DNA strand break induction coincided with SAPK/JNK phosphorylation at early (≤ 30 min) but not late (≥ 2 h) time points after exposure. Genotoxin…
Isolated, Subtle Neurological Abnormalities in Mild Cognitive Impairment Types.
2019
Isolated, subtle neurological abnormalities (ISNA) are commonly seen in aging and have been related to cerebral small vessel disease (SVD) and subcortical atrophy in neurologically and cognitively healthy aging subjects.To investigate the frequency of ISNA in different mild cognitive impairment (MCI) types and to evaluate for each MCI type, the cross-sectional relation between ISNA and white matter hyperintensities (WMH), lacunes, caudate atrophy, and ventricular enlargement.One thousand two hundred fifty subjects with different MCI types were included in the analysis and underwent brain magnetic resonance imaging. WMHs were assessed through two visual rating scales. Lacunes were also rated…
The importance of pattern similarity between Müllerian mimics in predator avoidance learning
2004
Müllerian mimicry, where unpalatable prey share common warning patterns, has long fascinated evolutionary biologists. It is commonly assumed that Müllerian mimics benefit by sharing the costs of predator education, thus reducing per capita mortality, although there has been no direct test of this assumption. Here, we specifically measure the selection pressure exerted by avian predators on unpalatable prey with different degrees of visual similarity in their warning patterns. Using wild-caught birds foraging on novel patterned prey in the laboratory, we unexpectedly found that pattern similarity did not increase the speed of avoidance learning, and even dissimilar mimics shared the educatio…
Our Friend and Mathematician Karl Strambach
2020
This paper is dedicated to Karl Strambach on the occasion of his 80th birthday. Here we want to describe our work with Prof. Karl Strambach.
Kriminālvajāšanas būtība un saturs
2017
Kriminālvajāšana ir kriminālprocesa obligāta stadija, kura ietilpst pirmstiesas procesā. Kriminālvajāšanas stadijā krimināllieta tiek sagatavota izskatīšanai tiesā. Tās būtība atspoguļojas lēmumā par personas saukšanu pie kriminālatbildības jeb apsūdzībā. Jo pats lēmums ir šīs apsūdzības ārējā forma, taču apsūdzības saturs ir tas, kas nosaka kriminālvajāšanas būtību. Apsūdzība ļauj noteikt pierādīšanas priekšmetu un robežas, atbilstoši realizēt tiesības uz aizstāvību. Darba mērķis bija izpētīt pirmstiesas procesa stadiju – kriminālvajāšanu. Noskaidrot, ko sevī ietver lēmums par personas saukšanu pie kriminālatbildības, apsūdzētā statusu, viņa tiesības un pienākumus. Darba gaitā tika apskatī…