Search results for "RMS"

Nuorten näkemyksiä avusta ja tuesta palvelujärjestelmässä, kun vanhemmalla on päihdeongelma

2018

Supporting Multi-Sided Platform firms to maintain rapid growth (and to avoid failure) over time through a Dynamic Business Modelling approach

2020

Over the last few decades, the diffusion of the sharing economy has nurtured continuous changes in business model opportunities with multi-sided platforms (MSPs) in many industries. MSPs are digital exchange platforms aiming at connecting unmatched demand- and supply- side participants through the use of internet technology. In many cases, such start-up initiatives have led to the creation of scale-up or high-growth firms (HGFs). However, in spite of the significant contribution to both economic development and employment, current studies seem to investigate primarily in an isolated perspective HGFs, MSPs and their business model innovation (BMI). The existing literature on HGFs focuses on …

Ultrasonic characterisation of poroux materials

2017

International audience; Acoustic models of the acoustics of porous and perforated media involve a set of physical parameters. Some of the parameters, the tortusity, the viscous and thermal characteristic lengths are defined for a perfect incompressible and inviscid fluid saturating the porous medium. It is shown that ultrasonic propagation in air-saturated materials can be used to determine these parameters. A basic method involving air-coupled ultrasonic transducers is presented. Variants of this method and a practical implementation of one of these is proposed.

De la performance musicale dans la Guyane traditionnelle : expression cognitive singulière d?une musique-verbe

2021

Guianese culture and traditional music, here evoked, are various. It is more a transcultural process that, along centuries, gave an original result born in the Americas, in Guiana in this case. It is a form of refoundation, of recreation of cultures and new human beings generally called Creoles. The musical performance, that I study here, is the echo of social and cultural space of this reformulation of thought, life, and conception of the world. It is, as well, a mean of transposition and transformation of the values issued of diverse sources and categories. It is in no way a second-rate cultural practice, as it is the place where were born philosophies and actions for common life as well …

The Role of Self-Control and the Presence of Enactment Models on Sugar-Sweetened Beverage Consumption: A Pilot Study

2019

The objective of the present research was to investigate associations of dispositional and momentary self-control and the presence of other individuals consuming SSBs with the consumption frequency of sugar-sweetened beverages (SSBs) in a multi-country pilot study. We conducted an Ambulatory Assessment in which 75 university students (52 females) from four study sites carried smartphones and received prompts six times a day in their everyday environments to capture information regarding momentary self-control and the presence of other individuals consuming SSBs. Multilevel models revealed a statistically significant negative association between dispositional self-control and SSB consumption…

The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma

2014

Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma. No information is available on the relations between the IL-31/IL-31R complex and B-cell lymphoma. Here we have addressed this issue in follicular lymphoma (FL), a prototypic germinal center(GC)-derived B-cell malignancy. IL-31 enhanced primary FL cell proliferation through IL-31R-driven signal transducer and activator of transcription factor 1/3 (STAT1/3), extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation. In contrast, GC B cells d…

Effects of the Blair/Brown NHS Reforms on Socioeconomic Equity in Health Care

2012

The central objectives of the ‘Blair/Brown’ reforms of the English NHS in the 2000s were to reduce hospital waiting times and improve the quality of care. However, critics raised concerns that the choice and competition elements of reform might undermine socioeconomic equity in health care. By contrast, the architects of reform predicted that accelerated growth in NHS spending combined with increased patient choice of hospital would enhance equity for poorer patients. This paper draws together and discusses the findings of three large-scale national studies designed to shed empirical light on this issue. Study one developed methods for monitoring change in neighbourhood level socioeconomic…

New methods of delivery of amphotericin B.

1993

Fungal infections continue to be a major problem in the management of immunocompromised patients. Despite its formidable toxicity and treatment failures, amphotericin B is still the drug of choice for most of these infections. One strategy for reducing the toxicity of amphotericin B and thus permitting administration of higher doses is that of using less toxic formulations. Entrapping amphotericin B into liposomes or binding it to other substances reduces its toxicity to host cells, whereas the selective binding of amphotericin B to ergosterol preserves its toxicity to fungal cells. Adding fungus-specific antibodies to such liposomes may further increase the efficiency of drug targeting. Th…

Reproductive strategy as a piece of the biogeographic puzzle: a case study using Antarctic sea stars (Echinodermata, Asteroidea)

2017

13 pages; International audience; AimTo describe and analyse asteroid biogeographic patterns in the Southern Ocean (SO) and test whether reproductive strategy (brooder versus broadcaster) can explain distribution patterns at the scale of the entire class. We hypothesize that brooding and broadcasting species display different biogeographic patterns.LocationSouthern Ocean, south of 45 °S.MethodsOver 14,000 asteroid occurrences are analysed using bootstrapped spanning network (BSN), non-metrical multidimensional scaling (nMDS) and clustering to uncover the spatial structure of faunal similarities among 25 bioregions.ResultsMain biogeographic patterns are congruent with previous works based on…

Fasciola spp: Mapping of the MF6 epitope and antigenic analysis of the MF6p/HDM family of heme-binding proteins

2017

MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized by the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other causal agents of important foodborne trematodiasis, such as Clonorchis sinensis, Opisthorchis viverrini and Paragonimus westermani. Considering that MF6p/FhHDM-1 is relevant for heme homeostasis in Fasciola and was reported to have immunomodulatory properties, this protein is expected to be a useful target for vaccination. Thus, in this study we mapped the epitope recognized by mAb MF6 and evaluated its antigenicity in sheep. The sequenc…