Search results for "ROLES"
showing 10 items of 329 documents
Halothane inhibits endothelium-dependent relaxation elicited by acetylcholine in human isolated pulmonary arteries.
1997
This study examined whether a clinically relevant concentration of the volatile anaesthetic halothane modifies the endothelium-dependent relaxation produced by acetylcholine (3 nM-10 microM), histamine (1 pM-0.1 microM) and anti-human immunoglobulin E (1:1000) in human isolated pulmonary arteries submaximally precontracted with noradrenaline. An inhibitor of nitric oxide formation, N(G)-nitro-L-arginine (100 microM), attenuated acetylcholine-induced relaxation but failed to inhibit histamine- and anti-human immunoglobulin E-induced relaxation. Indomethacin (2.8 microM, a cyclooxygenase inhibitor) preferentially reduced the relaxation to histamine and anti-human IgE. Halothane (2%) significa…
Natural Language Inference in Ordinary and Support Verb Constructions
2020
The family of clause types known as 'support (or 'light') verb construction' (SVC) manifests a peculiar syntax-semantics interface if compared with ordinary verb constructions (OVC). If, in e.g. She laughed, the verb licenses an argument and assigns it a semantic role, syntacticians of every stripe nowadays agree that it is the noun laugh, in She gave a laugh, which fulfils the same function. The differences between the two types have been extensively discussed in the linguistics literature (systematic research started in the 1970s), less so in Computational Linguistics. This paper has two objectives. First, it will propose an innovative type of semantic role, which is termed Cognate Semant…
NILLTPFN likuma prasību ievērošana Latvijas grāmatvedības ārpakalpojumu uzņēmumos
2020
Maģistra darba mērķis ir izpētīt noziedzīgi iegūtu līdzekļu legalizācijas un terorisma un proliferācijas finansēšanas novēršanas likuma prasības, aktualitātes un praksi attiecībā uz grāmatvedības ārpakalpojumu uzņēmumiem Latvijā. Praktiskajā daļā veicot dažādu avotu analīzi, autore nonāca pie secinājumiem, ka NILLTFNL prasību izpilde sagādā problēmas daudziem Latvijas grāmatvedības ārpakalpojumu uzņēmumiem- grūti izsekot likuma grozījumiem, subjektīva likuma izpratne, grūti noteikt savus un klienta riskus, un identificēt aizdomīgus darījumus. Autore piedāvā risinājumus, kā varētu uzlabot likuma prasību ievērošanu.
Development of new CdZnTe detectors for room-temperature high-flux radiation measurements
2017
Recently, CdZnTe (CZT) detectors have been widely proposed and developed for room-temperature X-ray spectroscopy even at high fluxes, and great efforts have been made on both the device and the crystal growth technologies. In this work, the performance of new travelling-heater-method (THM)-grown CZT detectors, recently developed at IMEM-CNR Parma, Italy, is presented. Thick planar detectors (3 mm thick) with gold electroless contacts were realised, with a planar cathode covering the detector surface (4.1 mm × 4.1 mm) and a central anode (2 mm × 2 mm) surrounded by a guard-ring electrode. The detectors, characterized by low leakage currents at room temperature (4.7 nA cm−2 at 1000 V cm−1), a…
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, mu…
2013
Contains fulltext : 118365.pdf (Publisher’s version ) (Closed access) BACKGROUND: Until now, only imatinib and sunitinib have proven clinical benefit in patients with gastrointestinal stromal tumours (GIST), but almost all metastatic GIST eventually develop resistance to these agents, resulting in fatal disease progression. We aimed to assess efficacy and safety of regorafenib in patients with metastatic or unresectable GIST progressing after failure of at least imatinib and sunitinib. METHODS: We did this phase 3 trial at 57 hospitals in 17 countries. Patients with histologically confirmed, metastatic or unresectable GIST, with failure of at least previous imatinib and sunitinib were rando…
Influencia del procesado industrial sobre las características químico-físicas y contenido en lípidos y antioxidantes del salvado de arroz
2009
Se investigaron las características químico-físicas de los salvados de arroz en distintos momentos de su procesado industrial, incluyendo materia prima (salvados de arroz blanco y vaporizado), salvado peletizado y salvado desgrasado. Se determinó la humedad, la acidez y el índice de peróxidos. Utilizando extractos en éter de petróleo y cromatografía de gases, se estableció el contenido lipídico total y los perfiles de los ácidos grasos. Mediante HPLC se determinaron los tocoferoles y el γ-orizanol. El salvado de arroz vaporizado mostró la mayor concentración de lípidos y la menor acidez, lo que indica que el vaporizado es el proceso más eficaz para estabilizar el salvado. Los ácidos oleico,…
SYNTHESIS OF PYRROLO[3,2-H]QUINOLINONES WITH GOOD PHOTOCHEMOTHERAPEUTIC ACTIVITY AND NO DNA DAMAGE
2010
In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline--bioisosters of the angular furocoumarin angelicin--were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity against a panel of four human tumor cell lines and a great dose UV-A dependence, reaching IC₅₀ values at submicromolar level. The mode of cellular death photoinduced by pyrrolo[3,2-h]quinolines was evaluated through a series of flow cytometric analysis and other tests were performed to clarify their mechanism of action.
Measurement invariance across gender and relationship with sociometric status
2014
In recent years, bullying research has transitioned from investigating the characteristics of the bully?victim dyad to examining bullying as a grouplevel process, in which the majority of children play some kind of role. This study used a shortened adaptation of the Participant Role Scale (PRS) to identify these roles in a representative sample of 2,050 Spanish children aged 8 to 13 years. Confirmatory factor analysis revealed three different roles, indicating that the adapted scale remains a reliable way to distinguish the Bully, Defender, and Outsider roles. In addition, measurement invariance of the adapted scale was examined to analyze possible gender differences among the roles. Peer s…
La incorporación de la perspectiva de género en la docencia universitaria del Grado en Relaciones Laborales y Recursos Humanos de la Universitat de V…
2020
[ES] En esta comunicación presentamos el Projecte d’Innovació Docent (PID) interuniversitari «Incorporar la Perspectiva de Gènere en la Docència Universitària del Grau en Relacions Laborals com a element d’Innovació i Pràctica de bona ciència» desarrollado en la Universitat de València. Este PID nace con la intención de dar impulso a la implantación de la perspectiva de género, de forma transversal, en la enseñanza del Grado en Relaciones Laborales y Recursos Humanos. Incorporar la perspectiva de género es necesario para formar profesionales en el mundo del trabajo. Los análisis de género con carácter integral son un elemento de Innovación de última generación que están logrando dar respues…
Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.
2002
Abstract The pyrrolo[1,2- f ]phenanthridines 8 – 22 and the corresponding non-rigid analogues 23 – 41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10 , 11 , and 13 showed a weak anti -HIV activity, whereas several pyrrolo-phenanthridines ( 8 , 10 , 16 – 18 ) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.