Search results for "ROLES"
showing 10 items of 329 documents
Anomalous Behavior of Zirconium and Hafnium in Volcanic Fumarolic Fluids
2022
The Zirconium and Hafnium concentrations in worldwide fumaroles fed by magmatic fluids reveal that the Zr/Hf ratio is inversely related to the temperature of emission. Lower Zr/Hf ratio values below the chondritic signature are found in fluids having the highest temperature while super-chondritic Zr/Hf ratio values are found in lower temperatures. Sub-chondritic values of the Zr/Hf ratio may be related to larger volatility of Hf-chloride gas species with respect to Zr-Cl gas species, while super-chondritic ratios may correspond to fluid-rock processes resulting from cooling of uprising magmatic fluids. We propose that subchondritic Zr/Hf ratio values in fumaroles associated with high temper…
High osmolarity glycerol (HOG) signalling in Magnaporthe oryzae: Identification of MoYPD1 and its role in osmoregulation, fungicide action, and patho…
2015
AbstractThis study comprises a first functional analysis of an YPD1-homologue in filamentous phytopathogenic fungi and its role in the HOG signalling pathway. We generated a gene deletion mutant of the gene MoYPD1 in Magnaporthe oryzae and characterized the resulting mutant strain. We have shown that MoYpd1p is a component of the phosphorelay system acting in the HOG pathway due to its Y2H protein interaction with the HKs MoHik1p and MoSln1p as well as with the response regulator MoSsk1p. Fungicidal activity of fludioxonil was reported to be based on the inhibition of MoHik1p resulting in hyperactivation of the HOG signalling pathway and lethality. Western analysis proved that both, osmotic…
Rapid adaptation of signaling networks in the fungal pathogen Magnaporthe oryzae
2019
Abstract Background One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. “Loss of function” (lof) mutants from components of the high osmolarity glycerol (HOG) signaling pathway in the filamentous fungus Magnaporthe oryzae are viable, but impaired in osmoregulation. Results After long-term cultivation upon high osmolarity, stable individuals with reestablished osmoregulation capacity arise independently from each of the mutants with inactivated HOG pathway. This phenomenon is extremely reproducible and occurs only in osmosensitive mutants related to the HOG pathway – not in other osmosensitive Magnaporthe mutants. The major compatible so…
Imaginarios femeninos a través de la prensa satírica: de Gil Blas a Don Quijote (1864-1902)
2015
Entre mediados del siglo XIX y principios del XX, el principal medio que difundio imagenes femeninas fue la prensa satirica. Esta exclusividad, junto con la elevada oferta de titulos y de ejemplares que circularon, le otorga un papel destacado en la configuracion de los imaginarios sociales. Nos proponemos analizar la evolucion grafica de la mujer entre el primer semanario satirico que las incluye, Gil Blas (1864-72), y el retrato mas social que llevara a cabo Don Quijote (1892-1902), con el fin de establecer los enfoques dominantes.
The precious treasure of Mariano Valenza: The history of Ludovico Sicardi and the birth of geochemical volcano monitoring
2020
I was lucky enough to meet Mariano Valenza in September 1995. I was hitchhiking on the highway that leads from Cefalu to Palermo to go back home. I had spent my summer holidays in the beautiful and wild Madonie mountains. An off-road vehicle (a Land Rover Defender) stopped and a refined gentleman with a curious and charismatic gaze offered me a ride. During our journey, we chatted pleasantly and he told he was originally from that area. When I told him, I was a Geology student, he smiled at me and said Then we will meet again soon, I am going to be your Teacher of Geochemistry!. After a few weeks the lessons began and I met again Professor Valenza in Via Archirafi 36, at the University of P…
Illicit trades and smuggling activities on the island of Stromboli, 1808–1816: gender roles during a commercial crisis
2020
This article examines the impact of the Continental Blockade upon a local fishing and agricultural economy in the Mediterranean by focusing on the illicit trades that flourished on Stromboli. The island became a strategic location for smuggling between the warring kingdoms of British allied Naples and French ruled Sicily. This paper argues that the Blockade allowed Stromboli to join the network of maritime traffic that had been dominated by the two biggest islands in the archipelago. Although equally integrated into agriculture and fishing, women participated in the fraudulent sale of prize goods but were excluded from large-scale smuggling operations. L'étude examine l'impact du Blocus con…
Total (fumarolic + diffuse soil) CO2 output from Furnas volcano
2015
Furnas volcano, in São Miguel island (Azores), being the surface expression of rising hydrothermal steam, is the site of intense carbon dioxide (CO2) release by diffuse degassing and fumaroles. While the diffusive CO2 output has long (since the early 1990s) been characterized by soil CO2 surveys, no information is presently available on the fumarolic CO2 output. Here, we performed (in August 2014) a study in which soil CO2 degassing survey was combined for the first time with the measurement of the fumarolic CO2 flux. The results were achieved by using a GasFinder 2.0 tunable diode laser. Our measurements were performed in two degassing sites at Furnas volcano (Furnas Lake and Furnas Villag…
Iekšējā kontroles sistēma, tās novērtējums un pilnveidošanas iespējas SIA "HML"
2016
Lai uzņēmums veiksmīgi darbotos, nepieciešama efektīva iekšējā kontroles sistēma (IKS), kura tiek pilnveidota pieaugot uzņēmumam. Darba mērķis ir uz SIA “HML” IKS novērtējuma bāzes, izstrādāt priekšlikumus tās pilnveidošanai šajā uzņēmumā. Lai sasniegtu darba mērķi, tiek salīdzināti dažādi literatūras avoti, izpētot IKS teorētiskos aspektus, tiek raksturota SIA „HML” saimnieciskā darbība, tiek izpētīta uzņēmuma IKS, intervējot uzņēmuma vadību un anketējot darbiniekus. Pēc iegūtajiem rezultātiem, IKS tiek raksturota un vērtēta pēc COSO modeļa. Darba gaitā tiek izdarīti secinājumi un kā viens no tiem ir – IKS SIA „HML” kopumā ir vērtējama, kā atbilstoša, tomēr ir jāveic tās pilnveide. Darba n…
Uz riskiem balstītas pieejas pielietošana zvērinātu revidentu darbā
2020
Maģistra darba tēma ir “Uz riskiem balstītas pieejas pielietošana zvērinātu revidentu darbā”. Darba mērķis ir, balstoties uz Starptautiskiem revīzijas standartiem un auditorfirmas metodoloģiju, novērtēt, kā revidējamās vienības uzņēmējdarbības vide un tās iekšējā kontroles sistēma ietekmē zvērināta revidenta iespēju savā darbībā samazināt riska līmeni, un izstrādāt ieteikumus revīzijas procesa uzlabošanai būtisku neatbilstības risku novēršanai. Maģistra darba ietvaros, pamatojoties uz autores novērojumiem, tika izstrādāti ieteikumi revīzijas procesa uzlabošanai būtisku neatbilstības risku novēršanai. Maģistra darba apjoms ir 96 lappuses, tas sastāv no 3 daļām, 24 tabulām, 24 attēliem, 2 pie…
Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor.
2006
We report on selectivity profiling of 1 in a panel of 20 protein kinases and molecular modeling indicating 1 to be highly active and selective for VEGF-R2/3. Sequence alignment analysis and detailed insights into the ATP binding pockets of targeted protein kinases from the panel result in a unique structural architecture of VEGF-R2 mainly caused by the hydrophobic pocket I, determining the molecular basis for activity and selectivity of 1.