Search results for "ROMP"

Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE.

2007

The drug binding to plasma and tissue proteins is a fundamental factor in determining the overall pharmacological activity of a drug. HSA, together with alpha(1)-acid glycoprotein, are the most important plasma proteins, which act as drug carriers, with implications on the pharmacokinetic of drugs. Among plasma proteins, HSA possesses the highest enantioselectivity. In this paper, a new methodology for the study of enantiodifferentiation of chiral drugs with HSA is developed and applied to evaluate the possible enantioselective binding of four antihistamines: brompheniramine, chlorpheniramine, hydroxyzine and orphenadrine to HSA. This study includes the determination of affinity constants o…

Determination of diphenhydramine hydrochloride by flow injection with Bromophenol Blue and turbidimetric measurement

1990

The study of a number of diphenhydramine-dye systems was carried out in order to determine the most suitable precipitate for the turbidimetric determination of diphenhydramine using flow injection (FI). The reagent selected was Bromophenol Blue. The chemical and FI variables were optimised. The calibration graph was linear over the concentration range 50-230 p.p.m. of diphenhydramine hydrochloride. A number of interfering substances were also investigated.

Characterization of antihistamine–human serum protein interactions by capillary electrophoresis

2007

An important topic in the drug discovery and development process is the role of drug binding to plasma proteins. In this paper the characterization of the interaction between antihistamines (cationic drugs) towards human serum albumin (HSA) and alpha(1)-acid glycoprotein (AGP) under physiological conditions by capillary electrophoresis-frontal analysis is presented. Furthermore, the binding of these drugs to all plasma proteins is evaluated by using ultrafiltration and capillary electrophoresis. Antihistamines present a wide-ranging behaviour with respect to their affinities towards plasma proteins. Orphenadrine, phenindamine, tripelenamine and tripolidine principally bind to HSA; carbinoxa…

"Table 1" of "Search for promptly produced heavy quarkonium states in hadronic Z decays"

1996

The analysis of hadrons (from X) provides to distinguish of the various decay modes of Z-boson (see text).

El descrédito de la democracia / 2: La corrupción

2006

Synthesis and ROMP activity of aminophenol-substituted tungsten(VI) and molybdenum(VI) complexes

2008

Abstract Tungsten(VI) and molybdenum(VI) complexes [MO(L1)Cl2] and [M(X)(L2)Cl3] (X = O, NPh) with tridentate aminobis(phenolate) ligand L1 = methylamino-N,N-bis(2-methylene-4,6-dimethylphenolate) and bidentate aminophenolate ligand L2 = 2,4-di-tert-butyl-6-((dimethylamino)methyl)phenolate) were prepared and characterised. These complexes are principally stable in open atmosphere under ambient conditions. When activated with Et2AlCl, they exhibited high activity in ring-opening metathesis polymerisation (ROMP) of 2-norbornene (NBE) and its derivatives. Especially complexes [M(NPh)(L2)Cl3], which are easily available from corresponding metal oxides MO3 by a simple three-step synthesis, were …

Klimt artwork: red-pigment material investigation by backscattering Fe-57 Mössbauer spectroscopy, SEM and p-XRF

2017

Material tests were performed on a rediscovered Klimt-artwork "Trompetender Putto". We performed studies on the red colored spots, mainly taken from non-restored parts. MIMOS II Fe-57 Mossbauer spectroscopy (novelty in art-pigment analysis) mainly reveals haematite and crystallized goethite in red colors. Electron microscopy can identify various layers of the original and overpainting of an artwork. The number of layers fluctuates between three and four chemically painted areas. The portable X-ray fluorescence analysis enables to reduce the pigment list to containing mercury (cinnabar), lead, zinc, iron and titanium. Infrared-light-irradiation visualizes the different age of the pigments.

Assessment of Catalysis by Arene‐Ruthenium Complexes Containing Phosphane or NHC Groups bearing Pendant Conjugated Diene Systems

2015

Two p-cymene-ruthenium complexes 1 and 2 were isolated in high yields by treating the [RuCl2(p-cymene)]2 dimer with new hybrid phosphane- or NHC-linked diene ligands. Both complexes were fully characterized by NMR spectroscopy, and the molecular structure of the ruthenium–p-cymene complex 1, containing the phosphane–diene ligand system, was determined by X-ray diffraction analysis. The catalytic activities of both compounds were probed in atom-transfer radical addition (ATRA) and polymerization (ATRP), in the cyclopropanation of olefins, in the ring-opening metathesis polymerization (ROMP) of norbornene, and in the synthesis of enol esters from hex-1-yne and 4-acetoxybenzoic acid.

Il trattamento dei disturbi da comportamento dirompente in età evolutiva

2014

Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol.

2016

Abstract To ensure the optimal performance of oral controlled release formulations, drug colon permeability is one of the critical parameters. Consequently developing this kind of formulations for low permeability molecules requires strategies to increase their ability to cross the colonic membrane. The objective of this work is to show if an ion-pair formation can improve the colon permeability of atenolol as a low permeability drug model. Two counter ions have been tested: brilliant blue and bromophenol blue. The Distribution coefficients at pH 7.00 (DpH7) of atenolol, atenolol + brilliant blue and atenolol + bromophenol blue were experimentally determined in n-octanol. Moreover, the colo…