Search results for "RPG"
showing 10 items of 16 documents
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry
2018
Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their proteins remains unclear. Here we show that knockdown (KD) of RPGR, RPGRIP1 or RPGRIP1L in hTERT-RPE1 cells results in abnormal actin cytoskeleton organization. The actin cytoskeleton rearrangement is regulated by the small GTPase RhoA via the planar cell polarity (PCP) pathway. RhoA activity was upregulated in the absence of RPGR, RPGRIP1 or RPGRIP1L proteins. In RPGR, RPGRIP1 or RPGRIP1L KD cells, we observed increased levels of DVl2 and DVl3 pr…
Problematic video game use as an emotional coping strategy: Evidence from a sample of MMORPG gamers
2019
Background A positive relationship between problematic gaming and escapism motivation to play video games has been well established, suggesting that problematic gaming may result from attempts to deal with negative emotions. However, to date, no study has examined how emotion dysregulation affects both escapism motives and problematic gaming patterns. Methods Difficulties in emotion regulation, escapism, and problematic involvement with video games were assessed in a sample of 390 World of Warcraft players. A structural equation modeling framework was used to test the hypothesis that escapism mediates the relationship between emotion dysregulation and problematic gaming. Results Statistica…
Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome.
2007
Peters, T.A./0000-0001-8443-5500; van Beersum, Sylvia E.C./0000-0002-4552-2908; Cremers, Frans/0000-0002-4954-5592; Roepman, Ronald/0000-0002-5178-8163 WOS: 000247619800019 PubMed: 17558407 Protein- protein interaction analyses have uncovered a ciliary and basal body protein network that, when disrupted, can result in nephronophthisis ( NPHP), Leber congenital amaurosis, Senior- Loken syndrome ( SLSN) or Joubert syndrome ( JBTS)(1-6). However, details of the molecular mechanisms underlying these disorders remain poorly understood. RPGRIP1- like protein ( RPGRIP1L) is a homolog of RPGRIP1 ( RPGR-interacting protein 1), a ciliary protein defective in Leber congenital amaurosis(7,8). We show t…
The role of different game-genres in predicting internet gaming disorder (IGD)
2020
Introduction: Internet gaming disorder (IGD) is a new diagnosis in DSM 5 worth of research. New potentially addictive features are emerging in pay- and free-to-play videogames, involving different at-risk populations of gamers. However, few studies have examined whether and how different game-genres can contribute to the risk of IGD. Objectives: This study aimed to investigate how game-genres can predict IGD, accounting for alexithymia scores, time-related play- ing habits, and other predictors. Methods: Participants were gamers joining online communities, surveyed about which games they played more than 20 hours in their lifetime, time-variables, other stressors and alexithymia scores. A s…
Economía en juego
2019
[EN] This article describes an innovative strategy aimed at teaching the subject “Political Economy”, in the University Degree in Political Science and Public Administration. Although the central methodology revolves mainly around “gamification”, it also requires activities as traditional as “taking notes” or “paying attention during class”. In addition, it provides the added value of demanding to expand and structure the information collected on the basis of structuring descriptors (glossary). Through a RPG –economic and political espionage at Bandung Conference– students collect, complete and organize the information offered by the teacher and return it through oral communications before …
LaboratorioRPGDocente: Un game-based learning para combatir la situación causada por la COVID-19 en instituciones educativas.
2021
[EN] Due to the pandemic caused by COVID-19, several educational institutions have been forced to close their facilities, and practical courses -such as laboratory practices- were impossible to carry out. Game-based learning can be found among many different digital learning techniques, and it consists in teaching the contents as a transversal inmersive element. This work will be focused on a simulation videogame, which allows the students to understand the simulated environment and to develop certain skills based on their interaction with the game interface. One of the main characteristics of these kind of video games is their high degree of realism. More specifically, in this project, stu…
A compensatory model to understand dysfunctional personality traits in problematic gaming: The role of vulnerable narcissism
2020
Abstract According to a “compensatory perspective”, this study aimed to examine the role of narcissism (both vulnerable and grandiose) in the relationship between emotion dysregulation, escapism motivation to play, and problematic gaming. In a sample of 405 World of Warcraft players, we tested a multiple mediation model in which the relationship between vulnerable/grandiose narcissism and problematic gaming was mediated by emotion dysregulation and escapism. Results showed that the model for vulnerable (but not grandiose) narcissism fitted the data very well. This study adds novel insight to our understanding of the mechanisms that support problematic gaming, suggesting that the emotion dys…
Zvaigžņotā Debess: 2008, Pavasaris
2008
Latvijas Zinātņu akadēmija, Latvijas Universitāte
Designing an Online Dungeons & Dragons Experience for Primary School Children
2020
In this work, we present the results of a role-playing game experience carried out with a group of 9- to 12-year-old children during the COVID-19 emergence. The ‘harmony in education’ approach has been used to adapt the game design to the constraints imposed by the online context and the young age of the students involved. The results show the effectiveness of the approach in terms of 21st-century skills training with particular evidence on perspective-taking.
Réalisation d'un MOS à grande échelle à partir de la BD Topo et du RPG: méthode et limites, caractérisation des lacunes, espaces non renseignés par l…
2014
National audience