Search results for "Rail"
showing 10 items of 699 documents
Frontline Professionals Performing Collaborative Work with Low-Income Families: Challenges across Organizational Boundaries
2020
This article discusses certain challenges relating to interagency collaboration between the Norwegian Labour and Welfare Administration (NAV) and Child Welfare Services (CWS). We have asked what obstacles to holistic work with low-income families who receive measures from NAV and CWS simultaneously can be identified. The departure point is collaboration on a local project at the municipal level. The differences between the views of the individual services (and the mandates based on these views) with regard to parental obligations have proved challenging. Using the theory of institutional logic, we have explored how different logics have influenced these services’ approaches to parenthood an…
WPŁYW PANDEMII COVID-19 NA FUNKCJONOWANIE REGIONALNEGO TRANSPORTU KOLEJOWEGO OBSZARÓW PRZYGRANICZNYCH – NA PRZYKŁADZIE WOJEWÓDZTWA DOLNOŚLĄSKIEGO (PL…
2021
Systemy zbiorowego transportu publicznego są narażone na wiele zewnętrznych czynników wpływających na ich funkcjonowanie. Jednym z nich może być zagrożenie epidemiologiczne. W 2020 r. światowa pandemia COVID-19 miała istotny wpływ na światową gospodarkę oraz przewozy pasażerskie. Wprowadzone liczne ograniczenia wpłynęły na popyt (liczbę pasażerów) oraz podaż (oferta przewozowa) na rynku transportu. Do najczęstszych obostrzeń zaliczyć można: ograniczenie liczby połączeń, zmniejszenie limitu pasażerów w pojeździe, ograniczenie siatki połączeń komunikacyjnych. W analizie autorzy przeprowadzili badanie województwa dolnośląskiego oraz kraju libereckiego w kontekście zmian w funkcjonowaniu region…
RESTRICTIONS ON REGIONAL PASSENGER TRANSPORT DURING EPIDEMIOLOGICAL THREAT (COVID-19) – AN EXAMPLE OF THE LOWER SILESIAN VOIVODSHIP IN POLAND
2020
The beginning of 2020 was associated with the appearance of the global coronavirus pandemic (COVID-19). The spread of the epidemic caused the introduction of an epidemiological emergency in Poland in early March (on March 12). This resulted in reduced public transport, including regional rail transport. In Lower Silesia, this concerned regional and fast connections. The conducted analysis concerns regional connections and is based on exploration of the spatial and the quantitative aspect of these changes. The transport offer before and after the announcing of the epidemic was analysed. The results showed that most of the transport restrictions concerned the peripheries of the voivodeship (l…
LYON PART DIEU, HUB METROPOLITANO CONTEMPORANEO
2014
Lyon Part Dieu, contemporary metropolitan hub. By François Decoster, Djamel Klouche and Caroline Poulin. This article introduces a series of concepts developed by the AUC in its research on the theme of mobility, transportation, and stations in contemporary cities. The “inexorable station” in fact debates the need, for contemporary stations and more in general transportation venues, to evolve as projects for open spaces, to be porous with respect to the city while establishing with it an organic relationship. Stations are not just specialized venues dedicated to transportation, but more than ever they are becoming “initiators”, essential levers for urban development and regeneration in toda…
Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level
2011
International audience; TNF-related apoptosis-inducing ligand or Apo2L (Apo2L/TRAIL) is a promising anti-cancer drug owing to its ability to trigger apoptosis by binding to TRAIL-R1 or TRAIL-R2, two membrane-bound receptors that are often expressed by tumor cells. TRAIL can also bind non-functional receptors such as TRAIL-R4, but controversies still exist regarding their potential to inhibit TRAIL-induced apoptosis. We show here that TRAIL-R4, expressed either endogenously or ectopically, inhibits TRAIL-induced apoptosis. Interestingly, the combination of chemotherapeutic drugs with TRAIL restores tumor cell sensitivity to apoptosis in TRAIL-R4-expressing cells. This sensitization, which ma…
Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
2011
Article Open access plus; International audience; The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement.
TRAIL in cancer therapy: present and future challenges.
2007
International audience; Since its identification in 1995, TNF-related apoptosis-inducing ligand (TRAIL) has sparked growing interest in oncology due to its reported ability to selectively trigger cancer cell death. In contrast to other members of the TNF superfamily, TRAIL administration in vivo is safe. The relative absence of toxic side effects of this naturally occurring cytokine, in addition to its antitumoural properties, has led to its preclinical evaluation. However, despite intensive investigations, little is known in regards to the mechanisms underlying TRAIL selectivity or efficiency. An appropriate understanding of its physiological relevance, and of the mechanisms controlling ca…
A linear regression-based machine learning pipeline for the discovery of clinically relevant correlates of gait speed reserve from multiple physiolog…
2021
Frailty in older adults is characterized by reduced physiological reserve. Gait speed reserve (GSR: maximum minus usual gait speed) could help identify frailty and act as a proxy for physiological reserve. Utilizing data from 2397 participants aged 50+ from wave 3 of The Irish Longitudinal Study on Ageing, we developed a stepwise linear regression-based machine learning pipeline to select the most important GSR predictors from 34 manually selected features across multiple domains. Variables were selected one at a time such that they maximized the mean adjusted r-squared score from a 5-fold cross-validation. A peak score of (0.16 +/- 0.03) was achieved with 14 variables (giving adjusted-r-sq…
Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
2018
Las herramientas habituales para evaluar la fragilidad muestran, entre otras características, una baja sensibilidad y un bajo valor predictivo positivo. Es por eso que, en este estudio prospectivo-retrospectivo, nos preguntamos si es posible identificar y desarrollar biomarcadores cuantitativos a partir de imágenes de ultrasonido muscular, para la identificación de sujetos con riesgo de fragilidad. Para ello utlilizamos el análisis de textura de ecointensidad con ayuda del aprendizaje automático (machine learning, en inglés) como enfoque experimental para responder a esta pregunta. El proyecto se desarrolló en consulta externa, donde se realizó la ecografía muscular. Al final de la adquisic…
Adherence to a Mediterranean diet is associated with lower incidence of frailty: A longitudinal cohort study
2018
Background & aims There is a paucity of data investigating the relationship between the Mediterranean diet and frailty, with no data among North American people. We aimed to investigate if adherence to a Mediterranean diet is associated with a lower incidence of frailty in a large cohort of North American people. Methods This study included subjects at higher risk or having knee osteoarthritis. Adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED) as proposed by Panagiotakos and classified into five categories. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of ≥2 out of: (i) weight loss ≥5% between b…