Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

6533b870fe1ef96bd12d0520

RESEARCH PRODUCT

Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

Sarah Shirley Micheau Olivier Alexandre Morizot

subject

MESH: Cell Death MESH: Signal Transduction Cancer Research Apoptosis TRAIL MESH : Models Biological scaffold Cell membrane 0302 clinical medicine Drug Discovery MESH: Animals Pharmacology (medical)Receptor death effector domain 0303 health sciences Cell Death General Medicine TRAIL-R4.3. Good health Cell biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Signal transduction MESH : Apoptosis Regulatory Proteins Signal Transduction Programmed cell death c-FLIP death domain medicine.drug_class MESH : Cell Membrane Cancer therapy Biology Monoclonal antibody Models Biological Article 03 medical and health sciences medicine Animals Humans Chemotherapy [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology MESH: Receptors TNF-Related Apoptosis-Inducing Ligand MESH : Receptors TNF-Related Apoptosis-Inducing Ligand [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular Biology 030304 developmental biology MESH : Signal Transduction MESH: Humans MESH: Apoptosis Regulatory Proteins MESH: Apoptosis MESH : Humans Cell Membrane MESH: Models Biological DISC Receptors TNF-Related Apoptosis-Inducing Ligand Apoptosis MESH : Cell Death FADD Cancer cell MESH : Animals Apoptosis Regulatory Proteins MESH : Apoptosis MESH: Cell Membrane

description

Article Open access plus; International audience; The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement.

year	journal	country	edition	language
2011-09-01	Recent Patents on Anti-Cancer Drug Discovery

https://doi.org/10.2174/157489211796957757

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