Search results for "Rating"
showing 10 items of 2021 documents
Rizatriptan in the treatment of migraine.
2006
Migraine is a common, disabling disorder associated with considerable personal and societal burden. Current guidelines recommend triptans for the acute treatment of migraine unlikely to respond to less effective therapies. Rizatriptan is a second-generation triptan available in tablet or orally disintegrating tablet (wafer) formulations that offers several advantages over other members of its class. Rizatriptan is rapidly absorbed from the gastrointestinal tract and achieves maximum plasma concentrations more quickly than other triptans, providing rapid pain relief. Clinical trials have shown that rizatriptan is at least as effective or superior to other oral migraine-specific agents in the…
La capitalización de los arrendamientos operativos: Análisis del impacto en las empresas del IBEX 35
2018
Purpose: This paper analyzes the consequences of the change in the accounting rules about operating leases in the companies and users of financial information. Design/methodology: We use the constructive capitalization method to estimate the liabilities and leased assets and perform an ex ante analysis of the regulatory impact in the IBEX 35 non-financial companies. Non-parametric tests are employed to examine the effect on certain ratios, and through a multivariate regression we investigate the business characteristics that explain the variation of EBITDA. Findings: The ratios under study are significantly affected by the capitalization of operating leases. The explanatory analysis shows t…
Promoting inter‐professional teamwork and learning – the case of a surgical operating theatre
2010
Hospitals, and surgical operating theatres (OTs) in particular, are environments in which inter‐professional teamwork and learning are essential to secure patient safety and effective practice. However, it has been revealed in many studies that inter‐professional collaborative work in hospital organisations faces many challenges and constraints. In this study we examine surgical operations as participatory practices from the perspective of inter‐professional learning and cooperation. We ask what kinds of shared practices enable learning and collaboration within the surgical operating team. We used an ethnographic approach to data collection including observations and interviews of surgical …
Multi-wave, multi-variable models of job insecurity: applying different scales in studying the stability of job insecurity
2001
The study had two specific targets: first, to examine the stability of job insecurity by utilizing three-year longitudinal data (n = 109) collected in Finland and, second, to clarify psychometric properties of four job insecurity scales, i.e., the global scale, the importance scale, the probability scale and the powerlessness scale. The study was carried out by means of questionnaires, which were answered on three occasions. Analyses were conducted using multi-wave, multi-variable models which were estimated and tested via the LISREL program. Generally, the results showed that job insecurity remained relatively stable during the follow-up period, although there were some variations in the s…
Oscillation results for second-order nonlinear neutral differential equations
2013
Published version of an article in the journal: Advances in Difference Equations. Also available from the publisher at: http://dx.doi.org/10.1186/1687-1847-2013-336 Open Access We obtain several oscillation criteria for a class of second-order nonlinear neutral differential equations. New theorems extend a number of related results reported in the literature and can be used in cases where known theorems fail to apply. Two illustrative examples are provided.
Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?
2019
International audience; In recent years, multiple strategies for eliciting anti-tumor immunity have been developed in different clinical studies. Currently, immunotherapy was clinically validated as effective treatment option for many tumors such as melanoma, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC). Some surface receptors of immune cells, called immune checkpoint receptors, may inhibit activity of proinflammatory lymphocytes, following binding with specific ligands. Cancer cells exploit these mechanisms to inactivate tumor-infiltrating lymphocytes (TILs) to escape from immunosurveillance. Among the different tumor-infiltrating immune cell populations, including leu…
Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases
2021
Simple Summary Metastasis is the main cause for cancer mortality. The most common metastatic sites of colorectal cancer (CRC) are the liver and lungs. Tumour-infiltrating lymphocytes are recognized as beneficial prognostic factors both in primary and metastatic CRC, but less is known about their reciprocal differences. The aim of our study was to evaluate immune microenvironment and its prognostic value in a series of mismatch proficient (pMMR) CRC with matched liver and lung metastases. The proportion of tumours with high immune cell infiltration together with PD-L1-positivity almost doubled in metastases compared to primary tumours. Our study confirmed the prognostic value of high ICS in …
Tunable all-optical negative multitap microwave filters based on uniform fiber Bragg gratings.
2003
We present a novel and simple technique for obtaining transversal filters with negative coefficients by using uniform fiber Bragg gratings. We demonstrate a wide tuning range, good performance, low cost, and easy implementation of multitap filters in an all-optical passive configuration in which negative taps are obtained by use of the transmission of a broadband source through uniform Bragg gratings.
Tunable chirped fibre Bragg grating device controlled by variable magnetic fields
2002
A novel dynamic chirping fibre Bragg grating device based on a magnetic field applied to a magnetostrictive transducer capable of tuning its dispersion is presented. Chirping ranges up to 300 ps/nm have been demonstrated, which are suitable for several applications such as tunable transversal filtering and dynamic dispersion compensation.
Fiber laser switched by a long period grating interferometer as an intra-cavity loss modulator
2010
Abstract In this paper we present an actively switched fiber laser with an all-fiber long-period grating-based interferometer used as an intra-cavity loss modulator. The modulator consists of two equal long-period gratings written sequentially in the same piece of a double-clad optical fiber. One of the gratings is fixed onto a piezoceramic cylinder producing fast modulation of the interferometer transmission spectrum. The laser demonstrates a stable regime of pulsed emission at repetition rates in the range of tens of kHz.