Search results for "Real"
showing 10 items of 4449 documents
Mitochondrial DNA content decreases during in vitro human embryo development: insights into mitochondrial DNA variation in preimplantation embryos do…
2020
Objective To assess the mitochondrial DNA (mtDNA) load and variation in human oocytes and during preimplantation embryo development using specimens donated for research. Design Prospective cohort study. Setting Not applicable. Patients A total of 50 in vitro fertilization patients and 11 oocyte donors whose specimens were obtained between July 2017 and July 2018. Interventions None. Main Outcome Measures All specimens were separately collected. Quantitative polymerase chain reaction was performed with SurePlex DNA Amplification System (Illumina). Primers for the adenosine triphosphate 8 mitochondrial gene and the β-actin were used. Data were statistically analyzed by analysis of variance wi…
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development
2014
Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essential in the embryo proper. Loss of LRP1 leads to lethal vascular defects with lack of proper investment with mural cells of both large and small vessels. We further demonstrate that LRP1 modulates Gi-dependent sphingosine-1-phosphate (S1P) signaling and integrates S1P and PDGF-BB signaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain. Loss of LRP1 leads to a lack of S1P-dependent inhibition of RAC1 and loss of constraint of PDGF-BB-induced cell migra…
Synthesis and Influence of 3-Amino Benzoxaboroles Structure on Their Activity against Candida albicans
2020
Benzoxaboroles emerged recently as molecules of high medicinal potential with Kerydin®
Otro mundo es posible
2001
Gluten-free flours from cereals, pseudocereals and legumes: Phenolic fingerprints and in vitro antioxidant properties.
2018
The interest in gluten-free (GF) products increases together with the increase in gluten-sensitive people. However, GF foods might have decreased nutritional quality as compared to the gluten containing counterparts. In this work, an investigation of the phenolic and antioxidant profile in 18 GF flours belonging to legumes, cereals and pseudocereals was achieved. Significant differences could be observed across samples. Total phenolic content was highest in violet rice flours, whereas total anthocyanins were highest in violet, nerone, and black rice flours. FRAP and ORAC antioxidant activities were correlated to phenolic contents and found to be higher in violet rice flours. Metabolomics hi…
Un Quijote de Picasso
2005
El presente ensayo propone una aproximación iconográfica a la obra cervantina de Picasso contenida en una carpeta, con veintiún grabados y un dibujo original en bolígrafo rojo, que forma parte de la colección Sedó depositada en la Biblioteca Nacional. Además de poner de manifiesto la vinculación con lo español del pintor, resulta ser una buena muestra de la inquietud creativa del artista malagueño en torno a 1936. (A)
Acute aortic dissection type A
2012
Abstract Background Acute aortic dissection type A (AADA) is a life-threatening vascular emergency. Clinical presentation ranges from pain related to the acute event, collapse due to aortic rupture or pericardial tamponade, or manifestations of organ or limb ischaemia. The purpose of this review was to clarify important clinical issues of AADA management, with a focus on diagnostic and therapeutic challenges. Methods Based on a MEDLINE search the latest literature on this topic was reviewed. Results from the German Registry for Acute Aortic Dissection Type A (GERAADA) are also described. Results Currently, the perioperative mortality rate of AADA is below 20 per cent, the rate of definitive…
The effects of forest management on wood-inhabiting fungi occupying dead wood of different diameter fractions
2014
Forest management has caused severe ecological degradation throughout the Globe. One of its most prominent consequences is the drastic change in dead wood profile and consequently in the dead wood dependent biota. Wood-inhabiting fungi are, considering ecosystem functions, the most important species group utilizing dead wood, because they take care of majority of the decaying process. The earlier research focusing on the effects of forest management on wood-inhabiting fungi has strongly focused on large dead wood pieces (i.e. coarse woody debris, CWD), even though it has been shown that a major part of fungal diversity utilizes (also) small dead wood pieces (i.e. [very] fine woody debris, […
Real-life assessment of chronic rhinosinusitis patients using mobile technology: the mySinusitisCoach project by EUFOREA
2020
Abstract Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient‐reported outcomes by mobile technology offers the possibility to better understand real‐life burden of CRS. Methods This study reports on the cross‐sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. Results The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major sy…
Dizaina un struktūrskices izstrāde virtuālās realitātes platformai
2021
Projektā “VR SafeScaff” tiek risināta problēma par atbilstošu lietotāja pieredzes un lietotāja saskarnes izstrādi, kas nodrošina pēc iespējas ērtāku un uztveramāku lietojamību un dizainu, balstoties uz vairāku pētījumu rezultātiem. Darba mērķis ir izstrādāt struktūrskici un dizainu virtuālās realitātes projektam “VR SafeScaff”. Darba rezultātā tika izveidota dizaina struktūrskice virtuālās realitātes platformai “VR SafeScaff”, kura arī tika veiksmīgi implementēta pirmajā programmatūras versijā. Apmācības platformas pirmo versiju arī aplūkoja neatkarīgi lietotāji un būvniecības nozares lietotāji, kuri deva savus ieteikumus tā turpmākai projekta attīstībai un uzlabojumiem. Darba apjoms – 68. …