Search results for "Rectal Cancer"

showing 10 items of 978 documents

Association of Vitamin K and Non-Vitamin K Oral Anticoagulant Use and Cancer Incidence in Atrial Fibrillation Patients

2021

The association between the use of vitamin K antagonists (VKAs) and cancer risk reduction remains unclear. We aimed to assess the association between the use of VKAs or direct oral anticoagulants (DOACs) and the incidence of cancer in a large cohort of patients with atrial fibrillation (AF) by means of a population-based, propensity-weighted cohort study using population-wide databases including patients diagnosed with nonvalvular AF (NVAF) followed for up of 5 years (median 2.94 years). We created two cohorts based on the initiation therapy (VKA or DOAC). Initiation with VKA or DOAC was defined as filling a prescription with no previous exposure in the preceding 12 months. Cancer diagnoses…

Malemedicine.medical_specialtyVitamin KColorectal cancerKaplan-Meier EstimateLower riskGastroenterologyRisk AssessmentTHERAPYWARFARINCohort StudiesFibrinolytic AgentsRisk FactorsInternal medicineNeoplasmsAtrial FibrillationmedicineHumansPharmacology (medical)Correlation of DataAgedProportional Hazards ModelsPharmacologyRISKbusiness.industryIncidence (epidemiology)IncidenceHazard ratioCancerAnticoagulantsAtrial fibrillationmedicine.diseasePROSTATE-CANCERCohortFemalebusinessCohort studyFollow-Up Studies
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High frequency of colorectal adenoma in patients with duodenal adenoma but without familial adenomatous polyposis

2004

Abstract Background Duodenal adenomas are extremely common in patients with familial adenomatous polyposis. However, it is uncertain whether patients with duodenal adenomas without familial adenomatous polyposis are at greater risk for colorectal neoplasia and, therefore, should routinely undergo surveillance colonoscopy. The aim of this study was to determine whether there is a correlation between non-papillary duodenal adenoma without familial adenomatous polyposis and colorectal adenoma. Methods Twenty-five patients with non-papillary duodenal adenomas without familial adenomatous polyposis, seen from January 1990 to April 2003, were retrospectively evaluated. Results Non-papillary duode…

Malemedicine.medical_specialtyendocrine system diseasesColorectal cancerBiopsyPopulationColonic PolypsColonoscopyColorectal adenomaGastroenterologyFamilial adenomatous polyposisNeoplasms Multiple PrimaryDuodenal AdenomaDuodenal NeoplasmsInternal medicineAdenoma VillousmedicineHumansRadiology Nuclear Medicine and imagingIntestinal MucosaeducationAgededucation.field_of_studymedicine.diagnostic_testbusiness.industryGastroenterologyPapillary AdenomaMiddle Agedmedicine.diseasedigestive system diseasesProctoscopystomatognathic diseasesCross-Sectional StudiesAdenomatous Polyposis ColiPopulation SurveillanceFemaleColorectal NeoplasmsbusinessGastrointestinal Endoscopy
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Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

2019

Background: End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods: This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associ…

Malemodelos logísticosmedicine.medical_treatmenthumanossurgial careColorectal Neoplasmpaíses desarrolladosLogistic regressionoutcomesGlobal Healthurgencias médicas0302 clinical medicinepaíses en desarrolloSurgicalestudios prospectivosColostomy80 and overglobalsurg030212 general & internal medicineProspective StudiesProspective cohort studyMultivariate Analysimediana edadCancerAged 80 and overEmergencieancianoAnastomosis colorectal resection colostomyAnastomosis SurgicalColostomyGeneral MedicineMiddle Agedadultocolostomy; colorectal cancer; human developlment index3. Good healthColo-Rectal Cancertraditional healersElective Surgical Procedures030220 oncology & carcinogenesisFemaleColorectal Neoplasms6.4 Surgerylow incomeCohort studyHumanDeveloped CountrieAdultAdult; Aged; Aged 80 and over; Anastomosis Surgical; Colorectal Neoplasms; Colostomy; Elective Surgical Procedures; Emergencies; Female; Global Health; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Developed Countries; Developing Countriesmedicine.medical_specialtyneoplasias colorrectalesLogistic Modelcancer anastomosis surgical income stomas colostomy procedure colorectal resection end colostomy emergency surgical procedure human development indexdelayAnastomosishuman developlment indexPerforation (oil well)lcsh:Surgerycolorectal cancerAnastomosisGlobalSurg CollaborativeNO03 medical and health sciencesCase mix indexClinical ResearchmedicinecancerHumansanálisis multifactorialDeveloping CountriesAgedemergency abdominal surgery low income surgial care traditional healers cancer mortality outcomes delayElective Surgical Procedurebusiness.industryKirurgiDeveloped Countriesleft colon resection anastomosis end colostomyEvaluation of treatments and therapeutic interventionslcsh:RD1-811Odds ratiomortalitySurgeryProspective StudieLogistic ModelsMultivariate AnalysisSurgeryEmergenciesbusinessDigestive Diseasescolostomíaemergency abdominal surgery
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Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cance…

2009

CONTEXT: Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC. OBJECTIVE: To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard. DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positiv…

Maleoccult blood testColorectal cancerColonoscopycancer riskprediction and forecastingGastroenterologyRisk Factorscancer diagnosisPositive predicative valueadvanced cancerMedicineFamily historycomparative studycolorectal adenomafamily historyeducation.field_of_studymedicine.diagnostic_testarticleclinical trialGeneral MedicineColonoscopyMiddle Agedpriority journalrisk factorPredictive value of testsdiagnostic accuracyFemalediagnostic valueColorectal NeoplasmsColonography Computed TomographicradiographyComputed TomographicAdultmedicine.medical_specialtySettore MED/12 - GASTROENTEROLOGIAPopulationcolorectal cancerSensitivity and SpecificityPredictive Value of TestsInternal medicineadult; advanced cancer; aged; article; cancer classification; cancer diagnosis; cancer risk; clinical trial; colonoscopy; colorectal adenoma; colorectal cancer; computed tomographic colonography; controlled clinical trial; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; family history; female; human; major clinical study; male; multicenter study; occult blood test; predictive validity; priority journal; colorectal tumor; comparative study; middle aged; prediction and forecasting; radiography; risk factor; sensitivity and specificity; Adult; Aged; Colonography Computed Tomographic; Colonoscopy; Colorectal Neoplasms; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Risk Factors; Sensitivity and Specificitycross-sectional studyHumanscontrolled studyhumaneducationAgedcontrolled clinical trialbusiness.industryFecal occult bloodSigmoidoscopyColonographymedicine.diseasecancer classificationcomputed tomographic colonographymajor clinical studypredictive validitymulticenter studyCross-Sectional StudiesCT colonography colorectal cancer screeningSettore MED/36 - Diagnostica Per Immagini E Radioterapiabusinesscolorectal tumorJAMA
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Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery

2019

Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery.A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a c…

Malerenal failureTime Factorsmedicine.medical_treatmentAdult; Aged; Anti-Inflammatory Agents Non-Steroidal; Elective Surgical Procedures; Female; Humans; Ileus; Kaplan-Meier Estimate; Male; Middle Aged; Patient Safety; Postoperative Care; Postoperative Complications; Proportional Hazards Models; Prospective Studies; Recovery of Function; Time Factors; Treatment Outcome; Colectomy; ProctectomyAnti-Inflammatory Agentscolorectal surgery; ileus; non-steroidal anti-inflammatory drugs; NSAIDSKaplan-Meier Estimate030230 surgeryTumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]0302 clinical medicinePostoperative ComplicationsProspective StudiesProspective cohort studyColectomyColorectalColectomyRISKProctectomyHazard ratioAnti-Inflammatory Agents Non-SteroidalAcute kidney injuryMiddle AgedColorectal surgeryNSAIDTreatment OutcomeElective Surgical Procedures030220 oncology & carcinogenesisFemalePatient SafetyNon-SteroidalCohort studyAdultcolorectal Surgery ileus non-steroidal anti-inflammatory drugsmedicine.medical_specialtyIleusNon‐steroidal anti‐inflammatory drugs. NSAIDs. Postoperative ileus. Colorectal surgery.ACUTE KIDNEY INJURYanti-inflammatory agents03 medical and health sciencesIleusInternal medicinemedicineHumansAdverse effectAgedProportional Hazards Modelsnon-steroidal anti-inflammatory drugs - ileus - colorectal surgeryPostoperative Carebusiness.industryRecovery of Functionmedicine.diseaseSettore MED/18 - Chirurgia Generalecolorectal cancer.Surgerycolorectal surgerybusiness
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Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer.

2021

The Mediterranean diet is a central element of a healthy lifestyle, where polyphenols play a key role due to their anti-oxidant properties, and for some of them, as nutripharmacological compounds capable of preventing a number of diseases, including cancer. Due to the high prevalence of intestinal cancer (ranking second in causing morbidity and mortality), this review is focused on the beneficial effects of selected dietary phytophenols, largely present in Mediterranean cooking: apigenin, curcumin, epigallocatechin gallate, quercetin-rutine, and resveratrol. The role of the Mediterranean diet in the prevention of colorectal cancer and future perspectives are discussed in terms of food polyp…

Mediterranean dietColorectal cancerdietary polyphenolsPharmaceutical ScienceOrganic chemistryReviewintestinal cancerEpigallocatechin gallateResveratrolresveratrolDiet MediterraneanAntioxidantsAnalytical Chemistryquercetin03 medical and health scienceschemistry.chemical_compound0302 clinical medicineQD241-441Mediterranean dietDrug DiscoveryMedicineAnimalsHumanscurcuminMicrobiomePhysical and Theoretical ChemistryCentral element030304 developmental biologyapigenin0303 health sciencesTraditional medicinebusiness.industryMicrobiotarutinCancerfood and beveragesPolyphenolsmedicine.diseaseIntestineschemistryChemistry (miscellaneous)Polyphenol030220 oncology & carcinogenesisMolecular Medicinebusinesspolyphenol nanoformulationColorectal NeoplasmsEGCGMolecules (Basel, Switzerland)
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POSSIBLE RELATION BETWEEN GUT MICROFLORA COMPOSITION AND ONCOGENIC RISK: IS STIMULATION OF INFLAMMATION THE ONE RING OF CONNECTION?

2012

Human intestinalmicrobiotais characterizedby highpopulationdensity, wide diversity and complexity of interactions. Dysbiosis, both qualitative and quantitative, might have serious health consequences including an increase in the number and/or alteration of bacteria colonizing the gastrointestinal tract, which could be referred as gut microflora imbalance (GMI). GMI is frequently found in patients suffering from irritable bowel syndrome; this is the reason why some authors believe that IBS is secondary to GMI. Interestingly, GMI is also found in about 25% of Crohn’s disease patients. Stimulation of inflammation by the ‘dangerous bacteria’, through specific activation of the intestinal immune…

Microbiology (medical)Gastrointestinal tractSettore MED/09 - Medicina InternaInflammationStimulationDiseaseBiologymedicine.diseaseCHRONIC INFLAMMATORY INTESTINAL DISEASES COLORECTAL CANCER COMMENSAL BACTERIA METABOLISM GUT MICROFLORA INTESTINAL STEM CELLS.Settore MED/18 - Chirurgia GeneraleImmune systemImmunologymedicinemedicine.symptomStem cellDysbiosisIrritable bowel syndrome
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Gut Microbiota Analysis in Postoperative Lynch Syndrome Patients

2019

Lynch syndrome (LS) is a dominantly inherited condition with incomplete penetrance, characterized by high predisposition to colorectal cancer (CRC), endometrial and ovarian cancers, as well as to other tumors. LS is associated with constitutive DNA mismatch repair (MMR) gene defects, and carriers of the same pathogenic variants can show great phenotypic heterogeneity in terms of cancer spectrum. In the last years, human gut microbiota got a foothold among risk factors responsible for the onset and evolution of sporadic CRC, but its possible involvement in the modulation of LS patients’ phenotype still needs to be investigated. In this pilot study, we performed 16S rRNA gene sequencing of ba…

Microbiology (medical)medicine.medical_specialtyfecal biomarkersColorectal cancerlcsh:QR1-502Faecalibacterium prausnitziiGut floraMicrobiologyGastroenterologylcsh:Microbiology16S sequencing03 medical and health sciencesInternal medicinemedicineOriginal Research030304 developmental biology0303 health sciencesfecal microbiotabiology030306 microbiologyGenetic heterogeneityfood and beveragesCancermedicine.diseasebiology.organism_classificationPenetrancedigestive system diseasesLynch syndromeLynch syndromeBacteroides fragilishereditary cancer predispositionFrontiers in Microbiology
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Double-Network-Structured Graphene Oxide-Containing Nanogels as Photothermal Agents for the Treatment of Colorectal Cancer.

2017

Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0% w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a…

Models MolecularPolymers and PlasticsColorectal cancerInfrared RaysProtein ConformationNanogelsBioengineeringNanotechnologyAntineoplastic Agents02 engineering and technology010402 general chemistry01 natural scienceslaw.inventionPolyethylene GlycolsBiomaterialschemistry.chemical_compoundgraphene oxide hydrogel nenogel cancer therapylawHyaluronic acidMaterials ChemistrymedicineCytotoxic T cellHumansPolyethyleneimineHyaluronic AcidGrapheneChemistryOxidesPhotothermal therapy021001 nanoscience & nanotechnologymedicine.diseaseHCT116 CellsIn vitro0104 chemical sciencesIrinotecanPhotochemotherapyCancer cellCancer researchGraphite0210 nano-technologyColorectal Neoplasmsmedicine.drugBiomacromolecules
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Havep53gene mutations and protein expression a different biological significance in colorectal cancer?*

2002

p53 alterations are considered the most common genetic events in many types of neoplasms, including colorectal carcinoma (CRC). These alterations include mutations of the gene and/or overexpression of the protein. The aim of our study was to assess whether in 160 patients undergoing resective surgery for primary operable CRC there was an association between p53 mutations and protein overexpression and between these and other biological variables, such as cell DNA content (DNA-ploidy) and S-phase fraction (SPF), and the traditional clinicopathological variables. p53 mutations, identified by PCR-SSCP-sequencing analysis, were found in 68/160 patients (43%) and positive staining for p53 protei…

Mutationmedicine.diagnostic_testPhysiologyColorectal cancerClinical BiochemistryCell BiologyGene mutationBiologymedicine.diseasemedicine.disease_causeMolecular biologyIntestinal mucosaDNA Mutational AnalysismedicineCancer researchImmunohistochemistryGeneGenetic testingJournal of Cellular Physiology
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