Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery

6533b7d1fe1ef96bd125ce16

RESEARCH PRODUCT

Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery

Sj Chapman D Clerc R Blanco‐colino A Otto D Nepogodiev G Pagano V Schaeff A Soares G Zaffaroni R ŽEbrák J Hodson R Blanco‐colino Sj Chapman Jc Glasbey P Pata G Pellino A Sgrò A Soares T Elst S Van Straten Ch Knowles D Nepogodiev J Hodson A Borakati Mf Bath Ih Yasin K Mclean T Arthur M Kovacevic S Delibegovic M Karamanliev M Swamad R ŽEbrák R Paramasivam A Martensen Hm Larsen L Rädeker Pe Frey A Kechagias A Venara E Duchalais A Ioannidis F Pata G Pellino S Pasquali A Sgrò A Simioni V Farina M Podda L Lorenzon V Schaeff A Otto M Jakubauskas Tr Elst M Chu Pvb Fagan Ci Wells A Alagoa João A Soares J Juloski D Clerc C Ciubotaru S Popescu A Yanishev S Lee Bb Ozkan A Yagız Sen Mk Aktas Be Baki B Yüksek Jc Glasbey S Kamarajah K Mclean A Borakati Ih Yasin Ra Khaw E Mills R Goodson N Thakral Ad Ablett M Adra I Kwek Sm Khan P Quinn Lr Manley A Badran A Ramjeeawon A Campbell Hl Tan Ds Rye N Rajaraman Jg Norman K Vutipongsatorn G Solomou M Akhbari A Ali V Murray Dm Baker Bd Brandao B Stainer R Thavayogan D Jones Oo Onafowokan A Gharooni N Dabab S Carlton‐carew G Kungwengwe M Gabriel E Sewart Tc Shortland S Lawday P Pockney A Dawson T Arthur Cd Brumfitt P Stewart B Ng Jk Luong S Delibegovic V Ivanov A Borisova V Neykov K Kunčarová B Kološová T Antonova M Farkašová R ŽEbrák Jl Harbjerg S Brandsborg S Brinck Md Kjaer A Mark‐christensen Kp Unbehaun P Dalsgaard Kd Lycke A Kechagias P Lenaoures E Duchalais C Brigand E Dumange M Gout C Moehwald M Prem O Alhalabi S Sliwinski J Krupp E Gablenz L Schmitzer A Kopp J Steinle J Gsenger Lj Pohl M Riccardi Im Christodoulou M Konstantinidis N Machairas A Zoikas D Balalis Dk Manatakis Ml Aguilera A Sgrò A Simioni L Marano F Fleres F Lovisetto D Sasia E Segalini G Pata A Lucchi A Sagnotta T Campagnaro F Petrelli G Gallo M Papandrea V Testa G Sinibaldi F Di Candido F Colombo G Perrone S Aresu A Biancafarina G Canonico M Pagnanelli G Curletti R Bini A Manzoni Garberini H Impellizzeri N Cillara R Tutino A Picciariello D Coletta G Savino F Ferrara N Tamini G Talamo D Parini P Giamundo A Lo Conte G Pagano V Ripetti A Pesce N Menduni G Pellino R Giudicissi M Podda E Goldin D Rega A Belli V Andriola L Gordini F Pata C Foppa G Piccolo A Birindelli C Ferrari Z Ballarini F Tirelli M Milone M De Rosa Ns Pipitone Federico B Molteni Pl Tilocca G Sancini Gn Piozzi A Lauretta G Poillucci S Mulas V Schaeff A Otto M Jakubauskas D Simcikas L Portelli Jwm Wijnbergen Tl Dinger Sfh Doesschate Ashm Dalen Dd Bos M Hansmann J Medina Feliz Sz Kuiper Z Abdulrahman Sr Pruijssers S Farik Bm Elliott Vp Geneta M Chu S Wilton H Kandelaki Sl Peng S Campbell Yk Lim Ss Yassaie M Murray Pvb Fagan C Haran J Tan J Castro A Laranjeira S Catarino C Neves‐marques Jg Correia Bn Vieira Ac Quintela Ml Serra J Maciel M Cunha Dj Aparício J Neves J Azevedo M Romano F Eiró J Romano C Monteiro M Claro Mr Almeida M Peyroteo Nd Machado H Capote M Ferreira X Sousa H Devesa D Cavadas I Guerreiro M Costa M Salman C English N Mohammed S Popescu A Yanishev A Litvin Vv ĆUk K Mészárosová S Van Straten R Jaich H De Lima S Brooks M Marx M Nshalati Salvation D Clerc B Blaser G Piazza B Gagliardi H Serin A Yagız Sen Ss Yurdaor Mk Aktas E Arslan O Kopac A Uyanik Bb Ozmen E Tiftik B Aksoy A Yalcinkaya F Ozoglu Md Kocer G Bilicen En Cinar Ö Uslu Y Kaya J Wong Mmh Farhan‐alanie G Suresh A Asif Bj Finch Y Bhahirathan J Herron Z Yi Tew R Obukofe C Russell I Suchett‐kay T Netke L Williams A Kisiel Fy Liu H Claireaux P James A Mondal R Kalderon Hh Nadama Z Al‐saraff Jph Tam A Powell‐chandler F Wood A Campbell Rebecca Gorgievska A Ragavoodoo C Thakrar D Rojoa C Palmer K Davidson L Giacci J Hale Fw Gan R Makin‐taylor Cy Hey C Toh Jm Findlay N Griffiths S Ganesananthan S Jasionowska M Poustie C Wong T Turner W Pyc W Sloper C Warner J Coey D Mason S Sait M Kowal Tc Shortland M Owen A Saiyed I Ashworth K Akbari M Curran P Martin D Parker A Dawson K Kwok C Lye P Pockney M Ghaly T Sammour D Lewis R Mundasad A Wilkes G Ctercteko P Stewart S Delibegovic S Maslyankov R Dimov S Iliev D Dimitrov F Marek J ÖRhalmi P Skalický T Skalický K Chrz P Christensen J Worsøe Es Kristensen Kj Emmertsen Us Loeve E Duchalais Al Mihaljevic F Herrle Km Konstantinidis Dk Manatakis D Korkolis I Karanikas Ml Aguilera L Vincenti G Anania F Borghi F Agresta I Maretto A Parisi L Bucci G De Palma A Guglielmi E Cucinotta F La Torre F Cianchi M Guerrieri A Lauretta M Trompetto R Persiani G Micheletto D Rega A Belli S Cantafio F Lovisetto M Ronconi Pag Bisagni M De Prizio N Tamini G Sinibaldi A Franceschi R Galleano M Cavallini A Brescia L D'ambra A Benevento P Niolu M Calgaro E Colangelo T Grottola Df Altomare S Puleo G Salamone A Pietrabissa G Poggioli V Ripetti E Erdas R Ottonello G Canonico V Tonini F Selvaggi G Sammarco G. Ceccarelli C De Nisco D Surgo L. Taglietti A Ozolins A Sivinš T Poskus J Psaila Wa Bemelman Lj Graat B Langenhoff Bpl Wijnhoven Ahw Ven M Poelman Lps Stassen G Slooter Yiz Acherman C Hoff Mf Gerhards Mwj Stommel Ej Hazebroek Aaw Geloven Ra Schasfoort Bl Leeuwen Jb Tuynman Mwa Tilburg Eg Boerma P Sharma B Jenkins Ip Bissett Sl Peng A Herd A Gordon D Vernon M Omundsen J Ly A Reddy G Bonnet C Harmston M Morales V Francisco S Costa A Manso E Amorim J Pereira J Cardoso S Ourô M Caratão C Nascimento B Ribeiro Da Silva V Taranu R Dias H Devesa J Mendes M Allen A Silva S Carlos E Barbosa C Carneiro L Ramos J Maciel L Lencastre R Martins P Silva‐vaz Pf Ridgway Da Mcnamara R Cahill A Hogan J Larkin Pr O'connell I Negoi A Abelevich Vm ĆUk M Vician C Ede I Sardiwalla S Mulira D Montwedi M Oyomno M Hübner D Petermann Mo Sauvain V Ozben Ie Geçim E Disçi A Rencuzogullari A Kurt T Bisgin M Pehlivan A Isik E Onur S Leventoglu Mc Haksal Ms Erturk M Keskin A Guner S Tutcu Sahin Gs Ozbalci A Pergel D Albayrak D Bruce N Fearnhead J Arthur M Harron G Beattie L Titu A Ali M Saunders J Phillips S Dindyal B Cresswell Y Gercek J Lee T Linn G Faulkner S Lockwood J Rees A Charalabopoulos B Campbell C Kontovounisios T Amarnath M Johnson E Epanomeritakis S Vigs P Nastro A Gilliam S Smolarek T Wilson J Orbell R Mcintyre T Agarwal P Hainsworth P Patel J Vijay B Liu P Dhruva Rao C Roxburgh M Vipond H Youssef C Thorn A Schizas S Denley D Bowley K Das T Cuming A Saha L Chung J Pitt P Davis O Jones M Taylor A Bhargava A Haji N Watson I Bloom B Singh M Norwood S Gurjar N Stylianides S Mirza M Evans G Williams P Patil J Hernon G Finch S Green K Chapple O Fafemi J Warusavitarne A Samee C Carden L Ong K Verma A Joseph N Rawat T Pinkney O Oke P Glen C Maxwell‐armstrong R Oliphant J Garner Sj Moug S Middleton Jn Lund Nj Smart G Osborn T Moore T Raymond Ch Knowles Ts Hany R Clarke G Khera R Brady C Sellahewa C Mason A Torrance K Lasithiotakis J Knight A Pullybank P Ainsworth F Reid A Ramwell S Maslekar R George A Skull S Holtham K Muhammad R Lal M Varcada Fm Smith M Howlader D Defriend S Kirk T Richards C Evans C Borg K Telford N Sarfraz K Busby J Hollingshead D Speake N Pawa D West M Chadwick O Komolafe S Richardson M Thornton A Goede C Osborne D Bandyopadhyay J Foong Yj Lee P Liebenberg D Mijalkov A Wells N Bull A Ajmera T Warburton S Morgan A Mahmoud M Schachtel B Mikhail I Fomin B Mekaeil N Taylor C Stevenson A Drane U Pahalawatta Lt Lai A Debiasio J Wong Hjs Jun R Hengpoonthana Dm Mendis Pm Robb Hj Lee Aab Wyche Lt Davis Hj Lee A Chrimes A Agarwal J Zhao S Williams Jmsn Jayalath P Liebenberg S Khor T Muddasani S Childs S Ridgway Nda Blefari H Tam N Puchalski C Ngai J Mackenzie N Johnson M Holmes R Zuzek T Saluja T Gould Yk Goh T Selvaraj Cd Brumfitt Yz Beh Nn Dudi‐venkata D Horne Jl Borrow C Campbell G Cousins L Jackson K Maheepala S Zhao E Holden L Tutt B Thompson H Collins F Louie B Buckland D Smith C Chong Th Chua C Nayak J Redmond Rr Tan M Gramlick Js Teh Ng Sy P Britten‐jones R Mohd Rosli Hdv Pham T Jegathees Smcj Coulter‐nile Mp Gosselink Jk Luong Yl Wang M Maciaszek Ps Chrapko A Nair V Thirugnanasundralingam K Muir M Salibasic V Pavlov T Paycheva A Borisova E Lyulenina N Kolev V Ivanov D Nguen Y Mitkov E Mitkov P Vladova V Dimitrov M Hussain A Gabarski T Ivanov T Yotsov I Ilieva M Karamanliev A Akisheva M Shoshkova E Nawaz H Feradova T Mladenov V Neykov V Jozaf M Farkašová T Klail M Pös A Adel O Sotona M Bartoš T Amjad O Malý S Berec M Hanušová M Hurný J Riško M Ludvik M Stercz R Treskoň M Pospíšil L Hlaváčová K Kunčarová D Tomanová S Chodora O Houdek R Novický T Antonova K Sobotková S Cha K šUta Kimle K Jirankova M Bujda A Paclík A Trap J Jürgens‐lahnstein M Storm P Dalsgaard I Damgaard F Olawi F Ehlem M Raos Fp Kristensen Kd Lycke K Bønnerup Kp Unbehaun Md Kjaer S Brandsborg S Amiri M Enevoldsen Jl Harbjerg J Højgaard Pedersen Bn Jepsen Tk Hillgaard Sb Erichsen Cv Nielsen Cp Madsen J Bjerke Cd Skejø Rr Aabling Js Sørensen A Mark‐christensen A Kechagias A Turunen J Katunin M Niskakangas T Vignaud S Frey C Ricolleau F Chanut J Magnin M Gout T Seiboldt L Beck Lj Pohl K Zamzow F Betge A Poncelet M Truant H Hauschild N Neugebauer L Schöning S Cs Simon C Galata I Karampinis T Thäwel Am Seckler C Kerem S Durdevic A Ioannidis F Antonakopoulos M Konstantinidis A Mathioulaki P Chrysoheris Pg Athanasopoulos V Kalles I Spyrou C Barkolias A Paspala N Machairas D Papaconstantinou E Spartalis N Arkadopoulos A Prodromidou Z Garoufalia D Balalis A Zoikas Im Christodoulou D Mendez J Rosales M Flores M Garcia A Garcia M Garcia Z Noriega D Torselli Ml Aguilera J Rodriguez S Lafranceschina E Artioli S Giaccari V Nevoso A Schimera S Marino P Geretto L Pellegrino B Borghi D Sasia A Marano C Corino G Cannata Mc Giuffrida F Landra G Pata D Ongaro G Baronio S Raimondo S Casiraghi R Salvadori G Savino E Finotti E Ciccioli A Galgano M Zuin A Simioni A Bettella A Barina E Vendramin G Palano D Schiavone A Di Cintio A Gemini S Trastulli M De Luca A Sagnotta J Desiderio F Gubbiotti M Cigognini G Zaffaroni A Maffioli S Colombo A Bondurri G Sampietro D Foschi F Colombo M Manigrasso M Danzi R Amato L Anastasio F Mastella R Basile R Peltrini E Marra G Luglio G Pagano M Giglio M Manigrasso P Anoldo S Vertaldi L Grimaldi N Tammaro C Pedrazzani T Campagnaro G Turri E Lazzarini C Conti I Vulcano E Bertilone G Pintabona F Viscosi S Cerasari G Galiffa P Lapolla D Coletta C Del Basso B Cirillo G De Toma K Fazzi S Bini F Coratti P Montanelli S Grandi T Nelli N Ben Khaled F Cammelli E Ferrini Me Billo Pl Tilocca Ag Marrosu F Scognamillo C Pala F Attene L Carboni Mw Ruggiu G Gabbas I Marziali S Mazzocato F Petrelli R Vergari F Piazzai I Kubolli A Aggiusti A Paolucci M Ortenzi M Olivieri C Belluco Ad Antona S Basso M Morino M Mistrangelo V Testa G Gallo G Clerico G De Santi Mf Bitonti M Trompetto Ns Pipitone Federico M Frattalone F Tirelli V Fico F Santullo F Belia A Spinelli M Marco F Di Candido M Bevilacqua D Tringali E Bevilacqua V Panizzo Gn Piozzi V La Manna G Migliore A Aversano A Fares Bucci F Marino F Carbone P Incollingo Fm Romano R Giudicissi T Zalla M Baraghini L Romoli M Calussi S Vellei C Genzano F Feroci M Vita A Barberis D Serra A Lucchi M Grassia M Romelli S Ruggiero A Percassi C Ferrari B Molteni A Magri Piccinini E Segalini M Monti M Magnoli S Romano P Gaetano F Pilotta L Baldassarre G Perrone E Bonati S Aresu A Saba G Moretto M Bacchion H Impellizzeri A Casaril M Inama M Creciun F Ferrara M Stella D Gobatti A Biancafarina M Angelini E Andolfi E Miranda M Scricciolo G Provenza G Cavallina B Frezza A Fontani R Malatesti Ga Pellicanò M Podda M Anania F Pulighe A Cruccu Ml Murru C Massaiu F Balestra M Pazzona C De Nisco A Giannella M Santangelo M Olivieri F Frangella D Magagnano P Liberatore R Brenna A Giani F Tirotta S Famularo M Angrisani M Ceresoli M De Rosa F Rondelli G Ceccarelli Gp Angelucci R Scaramuzzo A Larcinese C Fioriti E Picone M Nardi L Marano G Castagnoli A Bartoli R Bellochi A Spaziani D Conti V Poponesi M Trippetti S Amicucci G Tazza P Procacci F Giovannini E Basile A Franceschi G Caristo M Pagnanelli P De Nardi R Rosati G Marcocci A Vignali G Curletti R Galleano A Badran M Malerba A Percivale O Ghazouani L Reggiani C Spirito G Moschetta F Cosmi G Romeo M Gasparrini F Sucameli A Gennai E Moggia C Bianchi P Bonfante S Macina C Feleppa G Talamo M Imperatore Sm Tenconi S Rausei D Maioli V Marchionini F Pata C Sparta Fa Mura M Barmina A Lorettu C Rettaroli G Mastino Gv Ruggiu Ga Mura Ba Perrone M De Angelis A Mereu V Adamo C Bianco A Manzoni Garberini M Ricciardiello C Campanaro P Panaccio Lm Esposito F D'ascanio R Pietroletti A Picciariello N Chetta F Aquilino F Di Marco A Amico E Schembari S Puglisi L Licari S Campanella G Profita N Falco G Rotolo P Venturelli R Tutino P De Marco M Marcianò A Sgrò F Argenti Ms Milani S Malabarba G Giambartolomei I Vella F Gronchi A Ruggieri G Sancini A Roggiani F Balsamo A Gori D Cuicchi R D'alessio D Benvenuto L Gordini E Erdas F Podda F Cappellacci C Salaris S Sanna J Marcialis L Mosino M Peddis S Melis G De Donno Ac Aru E Falsetti D Parini J Lanari U D'errico S Bianchini A Birindelli F Figà A Caiazzo L Selvaggi A Capozzolo C Cerra M Pirillo M Papandrea S Cravano I Libri N Laquatra A Isabello A Truškovs A Bartnick E Malcevs Mj Machatschek J Alm S Lapsa M Delorme F Zeynalov J Larnovskis J Sauka D Bodrov R Gailumsis Am Wiemann Nl Müller I Jelovskis D Deksnis O Bauermeister Potts T Slimbajevs Ne Samalavicius D Simcikas V Nutautiene P Zeromskas J Jurgaitis O Aliosin A Slepavicius V Eismontas M Kybransiene A Dulskas J Kuliavas P Kavaliauskas R Kavaliauskaite E Poškus D Danys M Kryžauskas S Mikalauskas R Rackauskas M Drungilas T Poškus V Jotautas K Strupas C Cachia C Cefai L Portelli Y Youssef D Degaetano S Debono M Sammut J Cassar K Sammut R Looyen Ashm Dalen Maj Becker D Comert L Molder J Tromp E Matthee Ym Tissen E Brinkhuis Hs Vries E 'T Hart K Beckers Y Bekker S Kakar Sfh Doesschate Tc Smaalen Oc Veen Sa Dingemans Lc Brink Ghej Vijgen Emf Voort A Pool Klc Rest T Haak Nrf Sluijpers Sr Pruijssers Cjl Molenaar Mc Gordinou De Gouberville S Saleh Ma Mens Em Hoeks S Nieuwenhuizen Em Praag E Westerduin Mpcm Smit Sj Lely B Nasimi M Gerdsen Rch Stijns Tys Leow G Penningnieuwland A Ruiter T Ribbers Cam Aarts Ms Tulek J Jonge S Kocak Hj Alqethami R Constansia Pc Elst Mw Tissink A Grüter Y Vroom Dm Voeten T Feenstra J Azzahhafi S Bofarid M Kip W Saleh S Franssen Cl Boon Rjm Franssen I Romaen Mtf Jense J D'souza R Pascoe A Scott E Stark K Mulholland Wk Lau B Smith Sib Adams N Shah E Ling J Young Sl Peng A Jacobson H Macfater S Farik Sy Chen K Kilpatrick Dh Kim S Dixon S Yassaie D Welman J Coulter M Morreau E Li A Rankin J Winders C Skipworth Pvb Fagan B Stanfield N Henderson A Chuang L Maskill H Ker Sjp Mclaughlin J Kearney S Wilton H Sprosen P Kerckhoffs R Alsadat R Cherry Da Chapman N Singh A Clucas G Gatenby B Kelly P Ruppeldt Nd Mcintosh S Koh H Wilms F Dalzell J Tewhaiti‐smith T Kader St Yam D Dahya M Hardie Boys W Fleischl J Tan A Skavysh K Mouldey Bm Elliott R Hu S Edwards C Matthews E Aitken M Walker I Guerreiro M Tomé S Patrocinio F Amado A Batista J Seabra V Praxedes N Monteiro I Martins Ml Serra Tc Santos Rr Lages A Pimentel Nd Machado Sá Tc Fm Bernardes P Saraiva J Almeida M Mendes V Fernandes A Ribeiro D Soares M Costa M Rosete T Martins I Miguel J Martins Mf Cunha J Melo Dn Veiga J Rachadell E Amorim R Vareda J Roseira S Catarino D Aveiro M Couto Ar Loureiro H Louro T Queiros B Castro S Fonseca L Carvalho Ap Torre A Amado M Leite P Miranda C Cunha M Ferreira D Cavadas R Silva S Pina I Paixão L Orelhas J Santos A Pacheco Af Rocha Mj Jervis V Pedro V Paixão A Guerreiro D Melo D Correia V Capella T Moinhos C Monteiro M Silva Bn Vieira Ag Silva D Galvão A Mora R Bettencourt F Costa I Gil J Morgado J Neves I Mónica S Oliveira H Ribeiro M Ferreira N Guimarães M Duarte J Miranda Sf Martins Mr Almeida R Parreira A Faustino N Medeiros R Castro B Soares M Resendes P Almeida A Cruz M Claro G Vaz Pinto D Sousa D Costa Santos A Silva F Silva G Fialho M Reia N Pratas H Capote C Costa J Costa S Morais A Machado V Horta M Rocha‐melo J Patrício M Pereira R Lima Am Cinza J Oliveira C Velez M Ferreira F Borges J Simões F Eiró P Botelho B Cismasiu D Alves B Dias C Costa Jp Gonçalves P Valente J Oliveira L Freire R Saraiva M Moreira M Fragoso J Guimarães G Cruz Dj Aparício J Ribeiro I Borges Da Ponte S Almeida Ar Martins T Louro M Morgado As Ferreira M Alves N Oliveira R Lérias C Neves‐marques I Estalagem C Botelho J Bártolo C Fidalgo Antunes F Cabral F Brito Silva A Dias Matos M Santos R Cunha M Duarte M Sousa R Canotilho M Peyroteo Am Correia Pc Martins Jam Jardim Sp Domingos Jm Baião Bs Rocha Nmro Lopes Dm Jordão Jg Correia Md ÂNgelo T Caroço M Romano Jr Gomes Rg Monteiro S Varghese E Boyle L Aljohmani J Alexander V Graziadei C Mccaughey A Jain J Lee H Ramanayake R Sabnani Lf Colon N Bansal I Stephens R Tan S Sharma G Doherty S Fenn E Mulhare M Walsh C Leavey O Costigan S Griffin É Dockry E Khogali Ak Aly R Mcphedran D O'gorman D Vermeulen L Dervan Sj Kang O Dixon E Morrissey M Compton Ar Pentony Cl Piong R Nossier J Hanna K Sabir Sy Eow N Ladak D Boersma Pj Kamath Tbw Soh Ah Dyer Sy Chee Ixh Tan A Kelliher L Adeusi N Howarth N Mccawley A O'neill Mr Jones R Saleh A Singh R Senaratne P Kakodkar I Subramanian A Hogan A Al‐salihi V Vyas A Vedadi Ss Popescu K Piras Ci Ciubotaru A Litvin E Romanova N Ponomarev A Savchenko A Yanishev R Luzan E Lutovinova A Gavrilina A Barkovskaya N Kudelkina D Topchubaev R Radulović K Miloševic Vv ĆUk J Bojičić J Juloski M Genčić U Janković M Zubowicz Pk Sucháň J Gerstmeier K Mészárosová E Brazitikou E Fytrou M Celik M Dubovský J Schmalenbeck Sc Sautter H Ceyran R Jaich N Fitchat S Mathebula J Chauke W Mculu Z Ngwenya K Withey A Piperidis Y Toyi A Nicolaides T Jaffer A Sparke N Van Staden Cr Mcduling L Claassen C Kruger J Weyers M Marx J Lecler G Mignon A Vanoni A Henkens G Jarrar M Odovic M Willemin O Milliet D Hahnloser D Clerc N Demartines G Piazza H Teixeira O Pittet Ml Haller B Gagliardi A Huot B Blaser A Kefleyesus A Bugmann Lm Piotet L Meijers Gk Kurtoglu Ek Sel Vc Isler Bs Yilmaz C Adiyaman M Kara Hc Demirkaya Hk Korkmaz Am Pektas B Güner Ec İşlek Hb Tombul Cy Boztuğ A Tınaz M Yılmaz Y Karaman Fa Akın S Dansuk M Başçavuş M Kaya B Kutlu Mc Seker V Erten U Memis Zb Koçak Ye Karapinar M Fakirullahoglu Ö Uslu E Köseoglu M Yeni Mk Aktas N Aykun Mh Agca C Bilen I Kilinc C Atar V Kilic C Aktuna M Aba Ye Alim M Binbuga Ö Kürklü Ss Yurdaor C Ceylan S Yilmaz Sn ÇAlar N Yildirim G Yavuz A Yagız Sen B Can E Cesmeli D Kus Rc Kavar Ad Cevlik U Cengiz Eg Turk I Yilmaz B Yüksek H Erdönmez F Gürsoy H Serin H Kara U ÖNsal M ÖZbek Pa Kasar A Ipor D ÖZen M ÖLmez E Altintas Y Kaya R Toklu T Sariçiçek Ou Tipi Ge Benli I Tasdelen A Tura A Ucar B Ekci Ac Bilgili In Kiraz H Aksoy En Cinar A Basak M Erdem S Kayacan C Sahin M Uysal K Karakus S Altiner Zs Demirci E Eren M Yavas E Tiftik Ab Aksoy E Karagöz R Sabanci Ss Tümer K Kargici T Banaz Smf Abdulrahman M Yesilsancak E Yanikoglu A Karabulut D Yilmaz Of Kuyumcu F Kutluk B Emiroglu B Aksoy B Mollavelioglu D Gereklioglu M Guler S Toprak Hb Afsar Se Guler E Alizade Be Baki G Alemdag M Ulusahin E Arslan Eb Gul R Yildirim A Semiz G Bektur K Tomas G Bilicen E Yarenci Y Demiroglu A Sunal B Baykan H Abbasguliyev V Mutlu Y Mahmoudi Saa Dossa Sr Mizan B Demirtas T Cavus A Yuksek Ss Mazlum C Yelkenci T Baran M Satilmisoglu Az Sahin A Kilinç K Isik Ö Yumurtaci A Emin ÇAgri Girit Mk Yildirak E Senyigit A Güldag B Söyleyici Ye Aytin Fe Akay Ng Iskan B Mutlu Ao Sunay Ad Ablett T Tie‐gill G Ramsay L De Paola S Mcguckin A Alshakhs A Ahmeidat J Wong N Goergen Z Ali L Mullarkey Mf Bath R Walshe E Lewis B Berry J Moneim S Mookerjee S Christy O Ojofeitimi L Carroll A Hylands Lp Delaugere D Reveendran C Coulter C Ralston L Laverty P Gallagher A Ahmed Yq Yeo D Elliott J Bennett M Mcnamara S Sivarajah C Dunmore G Aitken M Nair Mh Aly M Buari Mmh Farhan‐alanie K Ahmed Z Sheikh M Monks J Lehmann O Rotimi T Bell D Limnatitou S Gormley P Taleongpong V Patel L Macgregor S Amini C Turner L Dwyer‐hemmings A Busuttil J Powell C Hensher F Vivian K Wcislo Z Millar S Hirosue I Ogunmwonyi D Nakakande I Kwek H Gaze A Nirmalanantha Am Bin Amran A Foulkes N Jones S Pillai G Khoury T Powell I Maleyko A Sangheli M Ransome M Isse O Aromolaran H Bholah J Anbarasan S Rehman E Hu S Timms W Reynolds A Hotchkies V Misra G Suresh V Murray L Theocharidou T Malik I Janmohamed B Carhart A Khan A Asif R Hullait P Quinn A Rylance S Butt J Leathes Bj Finch T Philip Rajathasan H Jeddy Ha Kyaw N Wong S Karelia Jm Clements M Rainey N Joshi A Rahman M Gallagher N Rebuffa R Abdelgalil R Siaw Yen Lai N Laurence S Thomas C Green R Frostick R Khera M Povey Hl Wong C Mccusker L Hlukha G Pike F Kamel R Thakkar C Donaldson M Sequeira Campos Y Bhahirathan Mn Armitage As Hussain B Hardy My Hassan Serry J Herron M Bradbury T Osunronbi Lyc Tam A Khanan Kaabneh J Lawther P Fisher T Tribedi A Moosa A Ramdin M Goble E Downs L Wheldon E Baggus A Mandal A Nayeem S Ahmed W Fradley C Wilson S Gallagher T Criswell J Ward A Mukkavilli B Stubbs W Fordyce N Suchdev S Wei Lim Z Yi Tew Sr Sookramanien A Chan G Bointas M Paul Kl Ward M Bagnall Sa Pherwani K Wang L Mitchell J Heyworth S Ayyar R Obukofe R Polson D Mason E Mackenzie C Russell N Doyle Z Habib M Zardab F Sartaj H Farooq M Tabibi Dj Drury Sj James R Barnett Ab Teasdale Etj Richardson Da Thomas S Ahmed Rl Williams Hf Najabat‐lattif E Cahya G Lou M Coyle K Homyer Ly Zhu M Woods J Chang H O'callaghan I Suchett‐kaye Th Mihailidis H Alawattegama E Seite A Barrett E Riordan W Lam M Dowdeswell C Mulvenna T Netke O Awokoya L Gurowich K Dhera S Hayat L Williams L Tincknell M Spazzapan F Teeling K Sysum J Latter M Latter S Khan M Guruswamy W Beedham E Brazier M Elghobashy M Bajaj H Mann E Etel M Woodmass H Hayden A Kisiel Y Ali S Husain A Arnold Ac Pedersen P Cunha M Ahmed S Al Zawawi V Kudva Fy Liu K Theodoropoulou M Miscampbell Av Robinson J Johnston A Dharni S Lamb T Westerman E Evans L Campbell M Gillespie Cm Cheong K Kulathevanayagam A Varghese Si Ike Tsm Chu B Baljer Jaw Mogg P Rai Ha Claireaux M Williams R Smillie J Goetz E Appleby T Fadipe S Vaughan‐burleigh G Puri P Hussain P James R Flather A Cutler S Pathak J Sheldon T Collicott M Al‐ausi A Mondal A Jovaisaite Sm Shah N Khalid D Gutmann S Davison Yj Alame L Syed Wj Owen Sd Ahsan R Kalderon U Anthony‐uzoeto C Macleod Hall S Zheng K Wynter C James D Sapre R Ghosh J Baird L Cockburn O Blackwood Hh Nadama W Simpson S Jeong S Bishop R Bate C Hobson Ah Adam C Redclift J Do O Adeleye F Poli A Batterham S Brown Jn Parekh W Clay K Pieri A Jackson S Brown A Saxena B Gurung T Oyebola F O'brien B Djeugam S Gardezi S Ul‐hasan Mp Martin‐hernandez M Sisley S Modi R Antakia A Elbayouk Yj Soh J Mather Z Yusuf Z Al‐sarraf M Naja Sb Rassool J Convill Y Nikookam A Warsame Jph Tam C Pace M Kiandee R Ridwan C Carey F Hirri Mja Mcmillan Jj Ling A Powell‐chandler L Pendelbury K Kerimzade A Tang Eo Howard S Humayun Oj Wadsworth K Tan F Abdelhameed C Haglund I Radnaeva N Hu S Rambhatla D Waldron P Madahar S Malik A Campbell Lc Meney I Ibrahim Ck Kang Jzj Chiu V Livie B Ibrahim M Khalil G Pooley B Shishkin R Gorgievska J Docherty A Southgate A Coomes F Mcgee S Flanagan C Thakrar Qj Tan H Anwar R Clough B Chrisp J Cassels Gwv Cross A Ragavoodoo L Mercer C Mercer A Refalo R Hadley A Mctighe F Farrow A Brodie G Davis Dr Shah C Bowers S Patel O Morice A Burzic J Cheung A Shashidhara G Theodoraki J Birk A Ong Ng Mpe Rtw Wong S Maese B Yeap Z Iqbal Dm Rojoa C Cabaleiro Barciela M Hussain Cm Ruddy S Lindwe Y Qamar S Chuita T Melaugh Jd Hall C Palmer O Kouli Asi Hassane Aw Azhar Tk Tan W Perchard T Scurr K Davidson E Campbell L Kelk A Ghosh A Gibbins D Mala A Loizidou O Hall L Mecia C Hew K Varathan L Tong B Chandrasekar L Giacci E Buchanan M O'connell Sy Kwak Eh Ong S Gardner J Lim C Maden M Illahi J Hale Z Xuan Tan S Edwards R Stahl J Stahl A Hickman D Collett Z Goolam‐mahomed B Allen A Atiyah H Ahmad J Jones O Mcgregor E Ogundiya Fw Gan A Boulbadaoui O Kirnon‐jackman Qx Lim H Peckham T Yeoh Sq Yong Jy Chen S Siva Zh Sam M Gilani Yn Goh Mg Muthukumar S Phillips R Makin‐taylor J Tjoakarfa A Giri S Suresan R Thavayogan Cy Hey P Thomas Ta Johnson Ri Williams A Rashid A Kushairi A Rais A James M Bugelli Y Chechelnitskaya N Sandhu C Toh R Tandon M Gray A Kumar C Ciurleo I Nyamali S Hiremath S Sinha M Chowdhary E Bradley M Mctiernan S Macdonald S Sharkey N Mclaughlin C Amey L Kraria O Skan C Kind Jm Findlay P Tupper C Van Rhee Si Honeyman G Menon M Ahmed L Jegatheeswaran N Griffiths A Madhavan M Warne Fl Malcolm T Lessware Ht Wilkerson S Chatterjee‐woolman A Yoong Wur Ahmed A Longshaw O Flannery R Green M Leaning J Cragg H Sharriff C Doherty S Ganesananthan Kwl Kwan L Sanders‐crook S Bhatia S Eames F Lewis P Kirupananthan Zy Boh S Dass A Soma A Newton M Hill Y Shafiq M Brkljac L Boyce S Jasionowska Wj English S Lam C Chipeta D Yilmaz C Jain T Garofalidou Sa Novotny S Locke C Bowman A Begaj C Murphy K Radcliffe Jt Chong M Poustie E Jeffrey N Chaudhury K Rajendran Z Akbar B Walters B Kulendrarajah N Tran S Shrestha S Parmar C Gallagher L Hennessy E Pentti S Badhrinarayanan A Fung M Mansoor R Kenny P Kan De Lee S Khosla M Samake F Shaban R Aftab M Gough B Woodburn S Vayalapra K Mcmurrugh C Wong D Jimulia S Deol S Pike Y Embury‐young T Turner M Patel E Kilgallon R Keating A Walsh H Khan G Logue M Orekoya M Alasmar M Charalambides A Clavé Llavall E Williamson Y Bharwada S Zearmal H Evans M Panikkar G Cruz J Caplan A Ruparelia T Tanvir C Soare Yl Pang J Trotter A Zaidi V Thakrar P Pulickal H Ahmed J Parnell H Khan S Lennock V Ford W Pyc R Brignall D O'neill R Hanna R Kane M Nicola K Rajput Y Xiao C Warner S Michael E Wright S Juniper E Thompson L Hoskyns A Kanitkar C Ross A Unsworth H Rshaidat K Demarre A Chiang A Bareh J Dellen C Faqihinejad A Gadhvi R Grant J Lewsey A Morris H Martin C Mcclarty S Sanyal A Alsaif A Palkhi S Bhopal S Vishnu K A Papanikolaou A Mitra A Nur F Ali C Burford T Huq W Sloper E Irwin L Matthews Ws Ngu T Hosfield F Muneeb O Page E Zeb J Coey A Al‐azzawi J Mcintosh A Vucicevic M Hughes L Brooks B Fanibi M Dixon P Njoku D Morris J Jobson H Chowdhury Dot Alawode W Wynell‐mayow V Udayachandran D Alsoof J Ekert N Joseph N Zulkefley G Hunt T Christodoulou O Wright S Soman M Jamal S Beqiri P Borgas S Christie F Pereira S Browne J Yiu A Dworkin J Brayley A Palmer M Charalambos Cj Jones S Toner R Cowden L Lee P Nicol O Holman M Imtiaz V Albert Sp Leung M Erotocritou J Wong R Stroud D Mason R Wilkin W Thomson L Mackee N G Y Bei S Sait S Mckenna Favier A Ibrahim A Kler L Reynolds Sh Mohamed Y Majeed B Fakim A Jones M Kowal G Liversedge Z Carrington J Windebank A Izzarina U Akbani J Craven A Aldarragi S Harding A Millward Tc Shortland M Bedford R Stroud R Obukofe E Mackenzie V Gopalan A Midgen P Khadka O Cheng S Taneja N Manobharath Jy Kok Dwe Lim T Buick M Boland S Piya R Devlin Cj Fairfield Rj George M Rahi S Zaman S Hajiev T Ross M Owen E Crisp C Thompson A Charalambous Jl Hollywood A Saiyed Rfl Hammond J Matthews V Mendonca J Spinty K Khan J Cheng N Glynn U Muhammad M Khan L Anderson K Mccormack J Mak S Patrawala N Milinkovic R Schofield M Chauhan L Hartley J Hind I Ashworth L Nelson D Ratnasingham K Akbari T Whitehead S Dimitriadis K Marshall Ej Flint M Curran C Horner A Heybourne H Morgan C Wickstone D Panagiotou E O'connell K Dean R Iqbal L Walsh N Yu N Rana E Massie J Ng M Jung Yd Lee M Harris S White S Delibegovic B Boev P Tonchev V Prochazka J ÖRhalmi J Riško A Skalický K Chrz S Ravn A Ojakäär E Duchalais C Dörr‐harim F Herrle C Koutserimpas G Giraudo A Armellini A Ruzzenente C Mazzeo C De Padua A Realis Luc A Maroli I Giani Me Cufari M Vitali G Ceccarelli Gp Gusai R Quattromani E Virgilio S Berti S Mulas Ff Di Mola V Papagni F Tuminello M Magnoli L Vittori A Longheu Ga Loche B Braccio E De Luca G Resta G Ancans A Tamosiunas M Petrulionis P Andrejevic Me Stellingwerf N Abdulrahman Kgh Pas G Thomas Am Brandsma J Davids Sj Rottier D Roy Van Zuidewijn R Hawkins Hi Ong Y Li B Desmond J Winstanley M Martins M Rosete M Americano M Santos S Frade R Senhorinho R Peixoto A Alagoa João C Alves‐vale M Lamas Db O'connor M Hoo A Gopaul K Scanlon N O'dwyer I Negoi M Jovanović A Panyko H De Lima S Van Vuuren P Curchod S Gaspar L Imadalou D Mutlu C Akyol Fa Uygur Ic Eray O Biyiklioglu Mf ÇEtin Ae Isik B Karip H Dogan L Sarıgül E Tunc T Aydin S Bodur K Karabulut Aa Francis A Al‐hadithi N To Isf Lau E Smith S Mahapatra O Mcauliffe Aa Francis L Imam B Akram S Hossaini R Davies M Ko J Collins A Pandya S Reilly J Archer C Auty Cd Roche J Livie Fa Chaudhry E Ntakomyti R Diallo T Bylinski J Wright S Lawday E Masiha J Tung B Shirazi A Neilson S Epton N Patel S Trussell A Couldrey C Donnelly S Eftychiou

subject

Male renal failure Time Factors medicine.medical_treatment Adult; Aged; Anti-Inflammatory Agents Non-Steroidal; Elective Surgical Procedures; Female; Humans; Ileus; Kaplan-Meier Estimate; Male; Middle Aged; Patient Safety; Postoperative Care; Postoperative Complications; Proportional Hazards Models; Prospective Studies; Recovery of Function; Time Factors; Treatment Outcome; Colectomy; Proctectomy Anti-Inflammatory Agents colorectal surgery; ileus; non-steroidal anti-inflammatory drugs; NSAIDS Kaplan-Meier Estimate 030230 surgery Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]0302 clinical medicine Postoperative Complications Prospective Studies Prospective cohort study Colectomy Colorectal Colectomy RISK Proctectomy Hazard ratio Anti-Inflammatory Agents Non-Steroidal Acute kidney injury Middle Aged Colorectal surgery NSAID Treatment Outcome Elective Surgical Procedures 030220 oncology & carcinogenesis Female Patient Safety Non-Steroidal Cohort study Adult colorectal Surgery ileus non-steroidal anti-inflammatory drugs medicine.medical_specialty Ileus Non‐steroidal anti‐inflammatory drugs. NSAIDs. Postoperative ileus. Colorectal surgery.ACUTE KIDNEY INJURY anti-inflammatory agents 03 medical and health sciences Ileus Internal medicine medicine Humans Adverse effect Aged Proportional Hazards Models non-steroidal anti-inflammatory drugs - ileus - colorectal surgery Postoperative Care business.industry Recovery of Function medicine.disease Settore MED/18 - Chirurgia Generale colorectal cancer.Surgery colorectal surgery business

description

Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery.A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury.A total of 4164 patients were included, with a median age of 68 (i.q.r. 57-75) years (54·9 per cent men). Some 1153 (27·7 per cent) received NSAIDs on postoperative days 1-3, of whom 1061 (92·0 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4·6 versus 4·8 days; hazard ratio 1·04, 95 per cent c.i. 0·96 to 1·12; P = 0·360). There were no significant differences in anastomotic leak rate (5·4 versus 4·6 per cent; P = 0·349) or acute kidney injury (14·3 versus 13·8 per cent; P = 0·666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35·3 versus 56·7 per cent; P 0·001).NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement.El ileo es frecuente tras cirugía colorrectal electiva y se asocia con un incremento de los eventos adversos y de la duración de la estancia hospitalaria. El objetivo fue evaluar el papel de los fármacos antiinflamatorios no esteroideos (non-steroidal anti-inflammatory drugs, NSAIDs) para reducir el ileo tras la cirugía. MÉTODOS: Estudio de cohortes prospectivo y multicéntrico efecuado por un grupo colaborativo dirigido por estudiantes y cirujanos en formación. Se incluyeron pacientes adultos sometidos a cirugía colorectal electiva entre enero y abril 2018. El resultado primario fue el tiempo hasta la recuperaciòn gastrointestinal, medido por una variable compuesta de función intestinal y tolerancia a la alimentación oral. El impacto de los NSAIDs se exploró utilizando un análisis de regresión de Cox, que incluía los resultados de una encuesta específica dirigida a los centros sobre la adherencia a los principios de la recuperación intensificada. Los resultados secundarios de seguridad incluyeron la dehiscencia anastomótica y la insuficiencia renal aguda.Se incluyeron 4.164 pacientes con una mediana de edad de 68 años (rango intercuartílico: 57-75; 54,9% varones). Un total de 1.153 (27,7%) pacientes fueron tratados con NSAIDs en los días postoperarorios 1-3, de los cuales 1.061 (92,0%) recibieron inhibidores no selectivos de la ciclooxigenasa. Tras los ajustes por las diferencias basales, el tiempo medio hasta la recuperación gastrointestinal no difería significativamente entre pacientes que recibieron o no recibieron NSAIDs (4,6 versus 4,8 días; cociente de riesgos instantáneos, hazard ratio, HR 1,04, i.c. del 95%: 0,96-1,12, P = 0,360). No hubo diferencias significativas en la tasa de dehiscencias anastomóticas (5,4% versus 4,6%; P = 0,349) o insuficiencia renal aguda (14,3% versus 13,8%; P = 0,666) entre los grupos. Sin embargo, significativamente menos pacientes de los que recibieron NSAIDs precisaron una analgesia intensa con opioides (35,3% versus 56,7%; P 0,001). CONCLUSIÓN: La administración de NSAIDs no redujo el tiempo hasta la recuperación gastrointestinal tras cirugía colorrectal, pero fueron seguros y se asociaron con una reducción en la necesidad de opioides postoperarorios.

year	journal	country	edition	language
2019-10-09

10.1002/bjs.11326 https://doi.org/10.1002/bjs.11326