Search results for "Repair"

showing 10 items of 747 documents

Effects of Chamomilla recutita (L.) on oral wound healing in rats

2011

Made available in DSpace on 2013-08-12T18:03:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-09-01 Made available in DSpace on 2013-08-12T18:03:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-09-01 Made available in DSpace on 2013-09-30T18:34:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-09-01 Made available in DSpace on 2013-09-30T18:34:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-09-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:04:30Z No. of bitstreams: 0 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:04:30Z No. of bitstreams: 0 Made available in DSpace …

MaleMucositisPathologymedicine.medical_specialtyMatricariaInflammationlaw.inventionLesionAndrologywound repairlawTongueDentistry Oral Surgery & MedicineAnimalsMedicineRats WistarMatricariaChamomilla recutitaFibroblastOral UlcerGeneral DentistryWound HealingMicroscopybiologyPlant Extractsbusiness.industryChamomile:CIENCIAS MÉDICAS [UNESCO]biology.organism_classificationoral ulcerRatsVivomedicine.anatomical_structureOtorhinolaryngologyIn-VitroUNESCO::CIENCIAS MÉDICASSurgerymedicine.symptomPhytotherapybusinessWound healingPhytotherapy
researchProduct

Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas

2020

Abstract Background Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guidelines, criteria for selecting patients with stage II small bowel adenocarcinoma to receive adjuvant chemotherapy are provided, and they are mainly extrapolated from studies on colorectal cancer. Patients and Methods In the present study, we aimed to verify whether mismatch repair deficiency phenotype, high-risk pathologic features (including T4, positive resection margi…

MaleOncologyColorectal cancerDNA Mismatch RepairCOLORECTAL-CANCERSettore MED/120302 clinical medicinePMS2small bowel adenocarcinomaMismatch Repair Endonuclease PMS20303 health sciencesPrognosisMMRMutS Homolog 2 ProteinOncologyCARCINOMAS030220 oncology & carcinogenesisimmunohistochemistryMismatch Repair Status small bowel adenocarcinomaFemaleMicrosatellite InstabilityDNA mismatch repairMutL Protein Homolog 1Colorectal Neoplasmsstage IImedicine.medical_specialtyhigh-risk pathologic featuresDNA Mismatch Repair; Female; Humans; Male; Microsatellite Instability; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; MutS Homolog 2 Protein; Prognosis; Adenocarcinoma; Colorectal Neoplasmssmall bowel adenocarcinoma; mismatch repair statusAdenocarcinomaNO03 medical and health sciencessmall bowel carcinomahistotypeInternal medicineTranslational ResearchmedicineHumansmismatch repair status030304 developmental biologysmall bowel adenocarcinomasbusiness.industryCancerMicrosatellite instabilityMismatch Repair ProteinAdenocarcinoma IBD Cancermedicine.diseasedigestive system diseasesMSH6COLORECTAL-CANCER; CARCINOMAS; CONSENSUSsmall bowel carcinoma MMR immunohistochemistryMismatch repair Small bowel AdenocarcinomaMSH2Mismatch repair status; stage II; small bowel adenocarcinomas; histotype; high-risk pathologic featuresSurgeryCONSENSUSbusiness
researchProduct

Cancer in Children With Fanconi Anemia and Ataxia-Telangiectasia—A Nationwide Register-Based Cohort Study in Germany

2021

PURPOSE Fanconi anemia (FA) and ataxia-telangiectasia (AT) are rare inherited syndromes characterized by abnormal DNA damage response and caused by pathogenic variants in key DNA repair proteins that are also relevant in the pathogenesis of breast cancer and other cancer types. The risk of cancer in children with these diseases is poorly understood and has never been assessed in a population-based cohort before. METHODS We identified 421 patients with FA and 160 patients with AT diagnosed between 1973 and 2020 through German DNA repair disorder reference laboratories. We linked patients' laboratory data with childhood cancer data from the German Childhood Cancer Registry. RESULTS Among 421 …

MaleOncologyRegister basedCancer Researchmedicine.medical_specialtyTime FactorsAdolescentDNA damageAnemiaDNA repairRisk AssessmentAtaxia TelangiectasiaRisk FactorsFanconi anemiaGermanyNeoplasmsInternal medicinemedicineHumansRegistriesChildbusiness.industryIncidenceAge FactorsInfantCancerPrognosismedicine.diseaseFanconi AnemiaOncologyChild PreschoolAtaxia-telangiectasiaFemalebusinessCohort studyJournal of Clinical Oncology
researchProduct

Searching for Gene Expression Differences in Primary Fibroblasts Between Patients with One and Two Neoplasms in Childhood

2012

Genetic factors are important for developing primary and subsequent malignancies in children. This study investigated the role of genetic factors involved in DNA-repair. Designed as a feasibility study, it addressed the possibility of obtaining samples for genetic analyses from former patients through the German Childhood Cancer Registry. Testing feasibility was as important as the biological question itself. We analyzed the expression of DNA-repair genes in untreated primary fibroblasts of 20 individuals with a second neoplasm compared to 20 matched single neoplasm cases using customized cDNA microarrays (1344 gene sequences, about 800 genes). Matching was by first neoplasm, age, and year …

MaleOncologymedicine.medical_specialtyAdolescentDNA RepairNeoplasmsInternal medicineGene expressionmedicineHumansNeoplasmChildGeneCells CulturedRegulation of gene expressionChildhood Cancer Registrybusiness.industryGene Expression ProfilingInfant NewbornInfantHematologyFibroblastsmedicine.diseaseCancer registryGene Expression Regulation NeoplasticGene expression profilingChildhood NeoplasmOncologyChild PreschoolPediatrics Perinatology and Child HealthImmunologyFemalebusinessPediatric Hematology and Oncology
researchProduct

The effect of biological sealants and adhesive treatments on matrix metalloproteinase expression during renal injury healing

2017

Background Renal injuries are relatively common in cases of abdominal trauma. Adhesives and sealants can be used to repair and preserve damaged organs. Using a rat model, this study explores the activity of different matrix metalloproteinases (MMP) during the healing of renal injuries treated by two biological adhesives (TachoSil and GelitaSpon) and a new synthetic elastic cyanoacrylate (Adhflex). Methods Renal traumatic injuries were experimentally induced in 90 male Wistar rats by a Stiefel Biopsy Punch in the anterior aspect of the left kidney. Animals were divided into five groups: 1, sham non-injured (n = 3); 2, non-treated standard punch injury (n = 6); 3, punch injury treated with Ta…

MalePathologyCritical Care and Emergency MedicinePhysiology030232 urology & nephrologylcsh:MedicineMatrix metalloproteinasePathology and Laboratory MedicineKidneyMMP8Biochemistrylaw.invention0302 clinical medicinelawMedicine and Health Scienceslcsh:ScienceImmune ResponseTrauma MedicineKidneyMultidisciplinaryProteasesTachoSilEnzymesmedicine.anatomical_structureTraumatic injuryCyanoacrylate030220 oncology & carcinogenesisPhysical SciencesAnatomyTraumatic InjuryResearch Articlemedicine.medical_specialtyHistologyMaterials ScienceImmunologyFibrin Tissue Adhesive03 medical and health sciencesSigns and SymptomsDiagnostic MedicineAdhesivesTissue RepairmedicineAnimalsRats WistarMaterials by AttributeInflammationWound Healingbusiness.industrylcsh:RBiology and Life SciencesProteinsKidneysRenal Systemmedicine.diseaseMatrix MetalloproteinasesAbdominal traumaEnzymologyMetalloproteaseslcsh:QPhysiological ProcessesbusinessWound healingCollagensPLOS ONE
researchProduct

Research of cardiomyocyte precursors in adult rat heart

2006

Recent reports supported the existence of stem cells in adult hearts. However, phenotype and localization of these cells have not been completely described and it is unknown if cardiac regenerative potential differs from one subject to another. The aims of our work were to identify different populations of cardiac stem cells by the analysis of specific markers and to evaluate the expression variability of these markers in 12 adult rat hearts. The expression of CD9, taube nuss and nanog suggests the presence of stem cells from the earliest stages of embryogenesis in adult myocardium. Their different expression could be associated to the degree of stem cell differentiation. CD34 and c-Kit ant…

MalePathologymedicine.medical_specialtyCellular differentiationAntigens CD34Nerve Tissue ProteinsBiologyNestinStem cells heart expression rat.Intermediate Filament ProteinsmedicineAnimalsCell LineageMyocytes CardiacAntigensRats WistarStem cell transplantation for articular cartilage repairInduced stem cellsMyocardiumStem CellsEndothelial CellsCell DifferentiationAmniotic stem cellsCell BiologyGeneral MedicineGATA4 Transcription FactorRatsEndothelial stem cellProto-Oncogene Proteins c-kitAmniotic epithelial cellsStem cellDevelopmental BiologyAdult stem cellTissue and Cell
researchProduct

Predilation technique with balloon angioplasty to facilitate percutaneous groin access of large size sheath through scar tissue

2017

Purpose Percutaneous remote access for endovascular aortic repair is an advantageous alternative to open access. Previous surgery in the femoral region and the presence of synthetic vascular grafts in the femoral/iliac arteries represent major limitations to percutaneous remote access. The aim of this study was to evaluate an original technique used for enabling percutaneous remote access for thoracic or abdominal endovascular aortic repair in patients with scar tissue and/or a vascular graft in the groin. Methods Twenty-five consecutive patients with a thoracic (11/25; 44%) or an aortic aneurysm (14/25; 66%) and with a synthetic vascular graft in the groin (16/25; 64%) or a redo groin acce…

MalePercutaneousmedicine.medical_treatment030204 cardiovascular system & hematologyBalloonEndovascular aneurysm repairSettore MED/22 - Chirurgia Vascolarecalcificationendovascular aneurysm repairAortic aneurysm0302 clinical medicinesheathprosthetic graftballoon angioplastyVascular closure device030212 general & internal medicineAged 80 and over10042 Clinic for Diagnostic and Interventional RadiologyVascular Access Deviceultrasonographyvascular closure deviceGeneral MedicineEquipment Design2746 SurgeryBlood Vessel Prosthesimedicine.anatomical_structureTreatment OutcomeFemaleRadiologyCardiology and Cardiovascular MedicineVascular Access DevicesHumanmedicine.medical_specialtycomplication610 Medicine & healthGroin2705 Cardiology and Cardiovascular MedicineAneurysm; balloon angioplasty; calcification; complications; endovascular aneurysm repair; infection; prosthetic graft; sheath; ultrasonography; vascular closure devices; Aged; Aged 80 and over; Angioplasty Balloon; Aortic Aneurysm Abdominal; Aortic Aneurysm Thoracic; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Catheterization Peripheral; Cicatrix; Equipment Design; Female; Groin; Humans; Male; Treatment Outcome; Ultrasonography Interventional; Vascular Access Devices; Surgery; Radiology Nuclear Medicine and Imaging; Cardiology and Cardiovascular Medicine03 medical and health sciencesBlood Vessel Prosthesis ImplantationCicatrixBlood vessel prosthesisAngioplastyCatheterization Peripheralmedicine2741 Radiology Nuclear Medicine and ImagingHumansRadiology Nuclear Medicine and imagingUltrasonography InterventionalAgedGroinAortic Aneurysm Thoracicbusiness.industrymedicine.diseaseAneurysminfectionSurgery10020 Clinic for Cardiac SurgeryBlood Vessel ProsthesisSurgerybusinessAngioplasty BalloonAortic Aneurysm Abdominal
researchProduct

Mid- and Longer-term Follow up of Chimney and/or Periscope Grafts and Risk Factors for Failure

2016

Objective The aim was to report on chimney and periscope grafts (CPGs) and their mid- and longer-term outcomes when they are used to preserve reno-visceral artery (RVA) perfusion in endovascular repair of pararenal (PRAAs) or thoraco-abdominal aortic aneurysm (TAAAs). In addition, factors associated with CPG failure are presented. Limited data exist on the outcomes of CPGs, and mid- and long-term results are generally not reported. Methods This was a prospective study in a cohort of 100 patients with PRAA (69) or TAAA (31). A total of 224 (mean 2.24 per patient) RVAs were preserved with 136 (61%) chimney and 88 (39%) periscope grafts. CPGs were constructed mainly using self expandable stent…

MalePercutaneousmedicine.medical_treatment030204 cardiovascular system & hematologyEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareAortic aneurysm0302 clinical medicineRenal ArteryRisk FactorsOcclusion030212 general & internal medicineTreatment FailureProspective cohort studyAortaPararenal aortic aneurysm10042 Clinic for Diagnostic and Interventional RadiologyReno2746 SurgeryAortic AneurysmFemaleRadiologyCardiology and Cardiovascular Medicinemedicine.medical_specialty610 Medicine & health2705 Cardiology and Cardiovascular Medicine03 medical and health sciencesEndovascular aneurysm repairabdominal aortic aneurysmAneurysmChimney and periscope graftChimney and periscope graft; Complex aortic aneurysm; Endovascular aneurysm repair; Pararenal aortic aneurysm; Reno-visceral arteries; Thoraco-abdominal aortic aneurysm; Cardiology and Cardiovascular Medicine; SurgerymedicineHumansAgedRetrospective StudiesReno-visceral arterieThoraco-abdominal aortic aneurysmbusiness.industryComplex aortic aneurysmStentRetrospective cohort studyThoracomedicine.diseaseSurgeryvisceral arteriesSurgeryVascular GraftingbusinessFollow-Up Studies
researchProduct

Surgical Atlas. Primary hypospadias repair with buccal mucosa

2006

MalePostoperative CareHypospadiasWound Healingmedicine.medical_specialtyUrologic Surgical Procedures Malebusiness.industryAdministration TopicalUrologyMouth MucosaInfantOral cavitymedicine.diseaseBuccal mucosaUrologic Surgical ProcedureSurgeryHypospadiasChild PreschoolMedical IllustrationHypospadias repairHumansMedicineTestosteronebusinessBJU International
researchProduct

Relocation of Papillary Muscles for Ischemic Mitral Valve Regurgitation

2014

Objective The assessment of the mitral valve apparatus (MVA) and its modifications during ischemic mitral regurgitation (IMR) is better performed by three-dimensional (3D) transesophageal echocardiography (TEE). The aim of our study was to carry out nonrestrictive mitral annuloplasty in addition to relocation of papillary muscles (PPMs) oriented by preoperative real-time 3D TEE through the mitral valve quantification dedicated software. Methods Since January 2008, a total of 70 patients with severe IMR were examined both before and after mitral valve repair. The mean (SD) coaptation depth and the mean (SD) tenting area were 1.4 (0.4) cm and 3.2 (0.5) cm2, respectively. Intraoperative 3D TEE…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyMitral Valve AnnuloplastyMyocardial ischemiamedicine.medical_treatmentTreatment outcomeMyocardial IschemiaEchocardiography Three-DimensionalThree-dimensional echocardiographyPapillary MuscleIschemic mitral valve regurgitationIntraoperative PeriodRetrospective StudieInternal medicineMitral valveMitral valve annuloplastymedicineHumansRetrospective StudiesAgedMitral valve repairIschemic mitral regurgitationbusiness.industryMitral Valve InsufficiencyGeneral MedicinePapillary Musclesmedicine.diseaseFeasibility StudieTreatment Outcomemedicine.anatomical_structureCardiologyFeasibility StudiesFemaleSurgeryIntraoperative PeriodbusinessMitral valve regurgitationCardiology and Cardiovascular MedicineMitral valve repairEchocardiography TransesophagealHumanInnovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
researchProduct