Search results for "Repair"
showing 10 items of 747 documents
Fixation free prosthetic repair of large umbilical hernia granting a broad defect overlap
2012
lntroduction: Umbilical hernia is a common surgical disease, accounting for l0-147o of all hernias and having many therapeutic options. Pure tissue repair is affected by a recurrence tp to 40Vo. Prosthetic mesh repair is now widely utilized with a decrease of recurrences up to 107o. Nevertheless, if large defect are present, assuring a wide overlap and a fixation-free technique still represent an issue. In this report we describe the outcomes of an umbilical hernia repair technique via a new implant with radiating straps at its boundary. Material and methods: A light weight, large porous polypropylene implant having a central body of 12x15 cm in diameter and eight radiating straps was used …
Fixation-free inguinal hernia repair using a dynamic self-retaining implant.
2012
Inguinal hernia repair remains controversial, despite advances in technique and materials. Conventional implants are typically static (passive) and do not move in concert with the groin's motility. Inguinal hernia repair with mesh fixation on dynamic groin structures are not tension free, and are associated with tissue tearing, bleeding, hematoma, and nerve entrapment--all which might contribute to mesh dislocation. The poor quality of tissue ingrowth within static meshes/plugs embodies another crucial issue in prosthetic hernia repair. Because the prosthetics used for inguinal hernia repair are incorporated by rigid fibrotic tissue (hence the term "scar plate"), the regressive tissue leads…
Dynamic inguinal hernia repair with a 3d fixation-free and motion-compliant implant: a clinical study.
2014
Static solutions for highly motile structures such as the groin seem to represent a procedural incongruence. Another important issue in prosthetic hernia repair is related to the poor quality of tissue ingrowth within conventional flat meshes and plugs. These are all static, passive devices, and thus do not move in synchrony with the natural movements of the groin. In the literature there is a clear understanding of how conventional prostheses used for inguinal hernia repair are incorporated by rigid fibrotic tissue. The term "scar plate" well emphasizes this occurrence. The ingrowth of this kind of stiff fibrotic scar leads to mesh shrinkage and to the reduction of the mesh surface area. T…
USO DELLA TUNICA VAGINALE DEL TESTICOLO NELLA CHIRURGIA DELL'IPOSPADIA
1993
Urethrocutaneus fistulas are the most common complication of surgery for hypospadias. In five patients, fistulas of this type were repaired with patches of tunica vaginalis to prevent fistula recurrence. Our experience and that of others suggest that tunica vaginalis autografts can be used for treatment of a variety of urethral problems in children.
Chimney endografting for pararenal aortic pathologies using transfemoral access and the lift technique
2013
Purpose: To present a technique for transfemoral implantation of parallel grafts into the renal arteries in patients with anatomy or morphology that blocks standard antegrade chimney graft delivery. Technique: In a totally percutaneous approach, a 5-F pigtail angiographic catheter is passed into the aorta above the renal arteries via a 0.035-inch hydrophilic guidewire, followed by an 8-F sheath. The target vessel is cannulated with the hydrophilic wire followed by a 5-F reverse curve catheter; the wire is changed for a Rosen wire. The main stent-graft body is delivered and parked at the level of the aortic bifurcation. The Viabahn chimney endograft is advanced ~1 to 2 cm into the target ren…
The effectiveness of 12 months' intensive shoulder strength training on disability, health-related quality of life and shoulder function after rotato…
2017
This study examined the effectiveness of intensive shoulder strength training on disability, health-related quality of life (HRQoL) and shoulder function in patients who had undergone rotator cuff repair (RCR). In addition, the self- report section of the American Shoulder and Elbow Surgeons Standardized Assessment Form (ASES) was cross-culturally adapted to the Finnish language and the psychometric properties of the Finnish version were assessed. Patients with a rotator cuff tear (aged 41-62 years) were randomized into an exercise group (EG, n=35) or a usual care group (UCG, n=32) after RCR. Disability was assessed with ASES questionnaire and quality of life with Short- Form 36 Health Surv…
Enhancement of lysine acetylation accelerates wound repair
2013
In physiopathological conditions, such as diabetes, wound healing is significantly compromised and chronic complications, including ulcers, may occur. In a mouse model of skin repair, we recently reported that wound treatment with Sirtuin activators and class I HDAC inhibitors induced keratinocyte proliferation and enhanced healing via a nitric oxide (NO) dependent mechanism. We observed an increase in total protein acetylation in the wound area, as determined by acetylation of α-tubulin and histone H3 Lysine 9. We reasoned that this process activated cell function as well as regulated gene expression to foster tissue repair. We report here that the direct activation of P300/CBP-associated …
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societi…
2021
The personalized medicine is in a rapidly evolving scenario. The identification of actionable mutations is revolutionizing the therapeutic landscape of tumors. The morphological and histological tumor features are enriched by the extensive genomic profiling, and the first tumor-agnostic drugs have been approved regardless of tumor histology, guided by predictive and druggable genetic alterations. This new paradigm of "mutational oncology", presents a great potential to change the oncologic therapeutic scenario, but also some critical aspects need to be underlined. A process governance is mandatory to ensure the genomic testing accuracy and homogeneity, the economic sustainability, and the r…
Molecular mechanisms of sorafenib action in liver cancer cells.
2012
Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib evolves, there is increasing interest in defining the mechanisms underlying its anti-tumor activity. Considering that this specific inhibitor could target unexpected molecules depending on the biologic context, a precise understanding of its mechanism of action could be critical to maximize its treatment efficacy, while minimizing adverse effects. Two human HCC cell lines (HepG2 and Huh7), carrying different biological and genetic characteristics, were used in this study to examine the intracellular events leading …
Right diaphragmatic injury and lacerated liver during a penetrating abdominal trauma: case report and brief literature review
2014
Introduction: Diaphragmatic injuries are rare consequences of thoracoabdominal trauma and they often occur in association with multiorgan injuries. The diaphragm is a difficult anatomical structure to study with common imaging instruments due to its physiological movement. Thus, diaphragmatic injuries can often be misunderstood and diagnosed only during surgical procedures. Diagnostic delay results in a high rate of mortality. Methods: We report the management of a clinical case of a 45-old man who came to our observation with a stab wound in the right upper abdomen. The type or length of the knife used as it was extracted from the victim after the fight. CT imaging demonstrated a right hem…