Search results for "Reserpine"
showing 10 items of 39 documents
Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isopr…
1977
The effects of theophylline (3×10−5 M–5×10−3 M), isoprenaline (10−6 M), excess calcium (7.2 mM) and ouabain (3×10−7 M) on force of contraction and c-AMP content were studied in electrically driven (frequency 3 Hz) left auricles isolated from guinea pigs pretreated with reserpine.
Der Einflu� von Reserpin auf die Wirkung der ?Neuro-Sympathomimetica?
1960
Investigation of the Alkaloid Content of Rauwolfia serpentina Roots from Regenerated Plants.
1991
The indole alkaloid content of RAUWOLFIA SERPENTINA roots from regenerated plants (from stem-and root-callus) was compared with the parental stock. Although the total alkaloid content seems to be slightly higher in the roots from regenerated plants, HPLC-analysis of individual alkaloids indicated that the contents of the alkaloids ajmaline ( 1), serpentine ( 2), and reserpine ( 3) are lower than in the roots of the parental stock. The glucoalkaloid raucaffricine ( 4) was identified as a constituent of all samples, thus providing the first evidence for its occurrence in roots of RAUWOLFIA SERPENTINA.
�ber den Mechanismus der positiv inotropen Wirkung von Theophyllin am Warmbl�terherzen
1971
In order to further elucidate the mechanism of the positive inotropiceffect of theophylline (T) in mammalian cardiac muscle, the influence of T on contractile force, extracellular space,45Ca uptake,45Ca release, and total myocardial calcium concentration was investigated in isolated, electrically driven (frequency 170 beats/min) or quiescent left guinea-pig atria. The investigations were performed in Tyrode solution containing 0.45 mM CaCl2. T concentration was 5×10−4 g/ml. Under these conditions, T exerted maximal positive inotropic but no toxic effects, that is, it did not cause contractures or arrythmias within 60 min (Fig. 1). The experiments provide evidence that T increases the rate o…
Die Aufnahme von ?-Methylnoradrenalin in das isolierte Kaninchenherz und seine Freisetzung durch Reserpin und Guanethidin in vivo
1965
Die Noradrenalin-Abgabe aus dem isolierten Kaninchenherzen bei sympathischer Nervenreizung und ihre pharmakologische Beeinflussung
1962
Die Wirkung von Cocain, Guanethidin, Reserpin, Hexamethonium, Tetracain und Psicain auf die Noradrenalin-Freisetzung aus dem Herzen
1961
Die Wirkung von Reserpin auf die Konzentration von Adrenalin und Noradrenalin im Katzenherz
1959
1. Cats were given single injections of 1.8 mg/kg reserpine intraperitoneally. After a time interval of 18 hours the animals were killed. The concentration of adrenaline and noradrenaline in the right and left atria and ventricles was estimated by a method reported previously. 2. Reserpine caused a similar loss of catechol amines from all parts of the heart. The concentration of noradrenaline was reduced by 93–97%, the concentration of adrenaline by 59–79%. 3. These observations suggest that the adrenaline of the heart behaves differently from that of sympathetic ganglia or postganglionic nerve fibres after an injection of reserpine. In ganglia and nerve fibres the adrenaline concentration …
The role of cytoplasmic (newly synthesized) dopamine for the spontaneous and electrically evoked release of dopamine and its metabolites from the iso…
1987
Isolated rat NILs were incubated in Krebs-HEPES solution. The release of dopamine and its metabolites (DOPAC, HVA and MOPET) was determined by HPLC with electrochemical detection. The spontaneous release of the sum of metabolites was about 40 times that of dopamine. The spontaneous outflow of dopamine metabolites was unaffected after inhibition of dopamine uptake (by GBR 12921) or after pretreatment with reserpine (5 mg/kg, 12 h before the experiments), but it was reduced by 50% after preincubation with the irreversible DOPA decarboxylase inhibitor, (MFMD, 10 microM, for 10 min). The combination of pretreatment with reserpine and preincubation with MFMD resulted in an 80% inhibition of the …