Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isoprenaline, calcium and ouabain

6533b820fe1ef96bd127a680

RESEARCH PRODUCT

Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isoprenaline, calcium and ouabain

Barbara Schmelzle Claudia Dönges Martin Heitmann Harald Jungbluth Thomas Meinertz Hasso Scholz

subject

Male medicine.medical_specialty Time Factors Contraction (grammar)Guinea Pigs chemistry.chemical_element In Vitro Techniques Calcium Ouabain Guinea pig Theophylline Internal medicine Isoprenaline Cyclic AMP medicine Animals Theophylline Ouabain Pharmacology Chemistry Myocardium Cardiac Pacing Artificial Isoproterenol General Medicine Reserpine Myocardial Contraction Propranolol C++ AMP Endocrinology Calcium Female medicine.drug

description

The effects of theophylline (3×10−5 M–5×10−3 M), isoprenaline (10−6 M), excess calcium (7.2 mM) and ouabain (3×10−7 M) on force of contraction and c-AMP content were studied in electrically driven (frequency 3 Hz) left auricles isolated from guinea pigs pretreated with reserpine.

year	journal	country	edition	language
1977-12-01	Naunyn-Schmiedeberg's Archives of Pharmacology

https://doi.org/10.1007/bf00501422

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