0000000000477829

AUTHOR

Hasso Scholz

showing 3 related works from this author

Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isopr…

1977

The effects of theophylline (3×10−5 M–5×10−3 M), isoprenaline (10−6 M), excess calcium (7.2 mM) and ouabain (3×10−7 M) on force of contraction and c-AMP content were studied in electrically driven (frequency 3 Hz) left auricles isolated from guinea pigs pretreated with reserpine.

Malemedicine.medical_specialtyTime FactorsContraction (grammar)Guinea Pigschemistry.chemical_elementIn Vitro TechniquesCalciumOuabainGuinea pigTheophyllineInternal medicineIsoprenalineCyclic AMPmedicineAnimalsTheophyllineOuabainPharmacologyChemistryMyocardiumCardiac Pacing ArtificialIsoproterenolGeneral MedicineReserpineMyocardial ContractionPropranololC++ AMPEndocrinologyCalciumFemalemedicine.drugNaunyn-Schmiedeberg's Archives of Pharmacology
researchProduct

Über den Einfluß von Mn++-Ionen auf die positiv inotrope Wirkung einiger Pharmaka an isolierten Meerschweinchenvorhöfen / The Influence of Mn++-Ions …

1969

An isolierten linken Vorhofen von Meerschweinchen wurde der Einflus von Mn++ -Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin bei verschiedenen extracellularen Calciumkonzentrationen ([Ca2+ e ; 0, 45–7, 2 mMol/l) untersucht. Die Praparate wurden elektrisch gereizt (Frequenz 3 Hz), die Spannungsentwicklung isometrisch uber Dehnungsstreifen auf Direktschreibern registriert. Die fur die Versuche verwendete Tyrodelosung enthielt keinen Phosphatpuffer, um ein Ausfallen von Mn++ zu verhindern. — Mn++ (0, 1 bis 50 mM) wirkte dosisabhangig negativ inotrop. Die Wirkung von Mn++ setzte sofort nach Zugabe ein. Sie war voll reversibel und nahm mit steigender [Ca2+ e …

InotropeGuinea pigChemistryMedicinal chemistry
researchProduct

The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase…

1978

The effects of phenylephrine on the shape of the contraction curve and on the cyclic adenosine 3',5'-monophosphate (c-AMP) content were studied in electrically driven (frequency 0.2 Hz) cat papillary muscles. All experiments were done in the presence of 1 micron propranolol in order to minimize interference from beta-adrenoceptors. 1. Phenylephrine increased the force of contraction in a concentration-dependent manner. Maximal effects (about 200% of control) occurred at 30 micron phenylephrine. 2. The positive inotropic effect (PIE) of phenylephrine was antagonized by phentolamine. Phentolamine, 5 micron, produced a parallel shift of the concentration-response curve for the PIE of phenyleph…

Inotropemedicine.medical_specialtyContraction (grammar)Time FactorsPharmacology toxicologyAdrenergic beta-AntagonistsPropranololIn Vitro TechniquesPhenylephrineHeart RateInternal medicinemedicineCyclic AMPAnimalsDrug InteractionsPhentolaminePhenylephrinePharmacologyChemistryMyocardiumGeneral MedicineAdenosineMyocardial ContractionPropranololC++ AMPStimulation ChemicalEndocrinologyCatsTime to peakmedicine.drugNaunyn-Schmiedeberg's archives of pharmacology
researchProduct