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showing 10 items of 8829 documents
The Bioactive Compounds and Antioxidant Activity of Food Products of Rhizophora stylosa Fruit (Coffee and Tea Mangrove)
2018
The objective of this study is to investigate the bioactive compounds and antioxidant activity of coffee and tea mangrove (locally known in Indonesia) produced from the fruit of Rhizophora stylosa. Furthermore, three raw materials of coffee mangrove were also investigated to clarify their potencies. The crude extracts of five samples were subjected to antioxidant assay using DPPH. The results show that the extract of tea mangrove has the strongest activity; then, it was successfully fractionated using different polarity of solvents and yielded acetone and methanol fractions that had high antioxidant activity. The acetone fraction was purified and gave fractions A1, A2, A3, A4, A5, and A6, b…
Effect of Jasonia glutinosa on immune and oxidative status of gilthead seabream (Sparus aurata L.).
2020
Jasonia glutinosa (rock-tea, RT) has numerous biological activities. In the present work, the beneficial effects of dietary RT on gilthead seabream (Sparus aurata L.) were studied. Fish fed experimental diets containing 0 (control), 10 or 30% of RT for 15 and 30 days. Samples from skin mucus, blood, head kidney, liver and gut were obtained at 15 and 30 days. The antioxidant properties from RT were analysed such as the antioxidant capacity and phenolic content. The heat shock protein 70 level (HSP70) and the total oxidized proteins were evaluated on skin mucus as stress markers. Immune parameters, both humoral (peroxidase activity, immunoglobulin M levels and complement activity) and cellula…
AMG900 as novel inhibitor of the translationally controlled tumor protein
2020
Abstract Introduction Cancer is one of the leading causes of death worldwide. Classical cytotoxic chemotherapy exerts high side effects and low tumor selectivity. Translationally controlled tumor protein (TCTP) is a target for differentiation therapy, a promising, new therapeutic approach, which is expected to be more selective and less toxic than cytotoxic chemotherapy. The aim of the present investigation was to identify novel TCTP inhibitors. Methods We performed in silico screening and molecular docking using a chemical library of more than 31,000 compounds to identify a novel inhibitor of TCTP. We tested AMG900 in vitro for binding to TCTP by microscale thermophoresis and co-immunoprec…
Replacement of fishmeal with corn gluten meal in feeds for juvenile rainbow trout (Oncorhynchus mykiss) does not affect oxygen consumption during for…
2017
Abstract We compared oxygen consumption (MO 2 , mg/kg/h) of c. 80 g rainbow trout ( Oncorhynchus mykiss ) in an intermittent-flow swim respirometer at 15 °C. Before the tests the fish were grown in flow through tanks (15 °C) with either fishmeal (FM) or corn gluten meal (CGM) based diets (c. 52% protein) for a period of 3–4.5 months. Ten individuals from both treatment groups were fasted for 48 h before the swim test, which consisted of 18 loops of 210 s over three different periods: acclimation period (6 loops at 0.5 body lengths per s, BL/s), exercise period (8 loops at increased speed from 1 to 2.5 BL/s with recovery loops at 0.5 BL/s), and a recovery period (four loops at 0.5 BL/s). We …
Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease.
2020
Postprint 36 páginas, 7 figuras
Risk Assessment of Hip Fracture Based on Machine Learning
2020
[EN] Identifying patients with high risk of hip fracture is a great challenge in osteoporosis clinical assessment. Bone Mineral Density (BMD) measured by Dual-Energy X-Ray Absorptiometry (DXA) is the current gold standard in osteoporosis clinical assessment. However, its classification accuracy is only around 65%. In order to improve this accuracy, this paper proposes the use of Machine Learning (ML) models trained with data from a biomechanical model that simulates a sideways-fall. Machine Learning (ML) models are models able to learn and to make predictions from data. During a training process, ML models learn a function that maps inputs and outputs without previous knowledge of the probl…
Spatial clustering of Borrelia burgdorferi sensu lato within populations of Allen's chipmunks and dusky-footed woodrats in northwestern California.
2017
The ecology of Lyme borreliosis is complex in northwestern California, with several potential reservoir hosts, tick vectors, and genospecies of Borrelia burgdorferi sensu lato. The primary objective of this study was to determine the fine-scale spatial distribution of different genospecies in four rodent species, the California ground squirrel (Otospermophilus beecheyi), northern flying squirrel (Glaucomys sabrinus), dusky-footed woodrat (Neotoma fuscipes), and Allen's chipmunk (Neotamias senex). Rodents were live-trapped between June 2004 and May 2005 at the Hoopa Valley Tribal Reservation (HVTR) in Humboldt County, California. Ear-punch biopsies obtained from each rodent were tested by po…
Assembly, growth and conductive properties of tellurium nanorods produced by Rhodococcus aetherivorans BCP1
2018
AbstractTellurite (TeO32−) is a hazardous and toxic oxyanion for living organisms. However, several microorganisms can bioconvert TeO32− into the less toxic form of elemental tellurium (Te0). Here, Rhodococcus aetherivorans BCP1 resting (non-growing) cells showed the proficiency to produce tellurium-based nanoparticles (NPs) and nanorods (NRs) through the bioconversion of TeO32−, depending on the oxyanion initial concentration and time of cellular incubation. Te-nanostructures initially appeared in the cytoplasm of BCP1 cells as spherical NPs, which, as the exposure time increased, were converted into NRs. This observation suggested the existence of an intracellular mechanism of TeNRs assem…
Evolution of organic carbon pools and microbial diversity in hyperarid anthropogenic soils
2016
Abstract We investigated the organic carbon pools and the microbial diversity and activity in anthropogenic terraced soils in a desert area of Southern Peru to highlight how the introduction of agriculture influences carbon evolution and storage and genetic and functional diversity of soil microbiota over time. Five sites were selected considering soils cultivated since 5, 15, 20, 35 and 65 years, sampled along the profile depth (0–20 and 20–40 cm layer). Soil and microbial parameters comprised by organic carbon pools, microbial respiration, microbial community physiological profile (CLPP) and microbial diversity (PCR-DGGE) were determined. The results showed that the highest C concentratio…
Decreased consumption of branched-chain amino acids improves metabolic health
2016
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino…