Search results for "Retraction"

An expression of concern on research during the Covid-19 pandemic

2020

Retracted papers on SARS-CoV-2 and COVID-19

2021

Property and cross-border couples from the perspective of European regulation

2021

The family property regimes constitute a relevant sector of the EU regulatory framework strongly connected with fundamental rights policies. Family property offers specific issues which need to balance individual rights with general interests, especially in matter of real estate property. The fragmentation of the discipline in EU Family law, the diversity of the domestic rules regarding rights in rem requires a large use of flexibility from EU legislator and EU legal professionals. The discipline provides by EU Regulations 1103 and 1104/2016 could be an interesting example to manage cross-border couple?s interests: the principles of universality and unity have to be used appropriately and, …

IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity

2012

Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and display pleiotropic features. Here we report that coculture of Vγ9Vδ2 cells with phosphoantigen and IL-21 leads to selective expression of the transcription repressor Bcl-6 and polarization toward a lymphocyte subset displaying features of follicular B-helper T (T(FH)) cells. T(FH) like Vγ9Vδ2 cells have a predominant central memory (CD27(+)CD45RA(-)) phenotype and express ICOS, CD40L and CXCR5. Upon antigen activation, they secrete IL-4, IL-10 and CXCL13, and provide B-cell help for antibody production in vitro. Our findings delineate a subset of human Vγ9Vδ2 lymphocytes, which, upon interaction w…

Examples of proper k-ball contractive retractions in F-normed spaces

2007

Abstract Assume X is an infinite dimensional F -normed space and let r be a positive number such that the closed ball B r ( X ) of radius r is properly contained in X . The main aim of this paper is to give examples of regular F -normed ideal spaces in which there is a 1-ball or a ( 1 + e ) -ball contractive retraction of B r ( X ) onto its boundary with positive lower Hausdorff measure of noncompactness. The examples are based on the abstract results of the paper, obtained under suitable hypotheses on X .

Internal inverse limits and retractions

2015

We establish equivalences between compacta that admit a sequence of retractions that converge uniformly to the identity map and compacta that are inverse limits on subcompacta with retractions for bonding maps. We give partial answers to questions of Charatonik and Prajs, and of Krasinkiewicz. Our results are related to and use results from another paper of the authors \cite{mp}.

Lipase maturation factor 1 is required for endothelial lipase activity

2011

Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and hepatic lipase (HL) into active enzymes. Mutations in Lmf1 are associated with diminished LPL and HL activities ("combined lipase deficiency") and result in severe hypertriglyceridemia in mice as well as in human subjects. Here, we investigate whether endothelial lipase (EL) also requires Lmf1 to attain enzymatic activity. We demonstrate that cells harboring a (cld) loss-of-function mutation in the Lmf1 gene are unable to generate active EL, but they regain this capacity after reconstitution with the Lmf1 wild type. Fur…

From [emotion] to [against will]: the Process of Grammaticalization of malgrat in the 12th-16th centuries

2018

L’estudi que presentem se centra en el procés de gramaticalització de malgrat, des del paper com a Sintagma Nominal originari que expressa una [emoció] fins al valor de [contra voluntat] que arribà a assolir com a Sintagma Preposicional. Parem esment especialment en la retracció que experimentà malgrat justament a partir del segle xvi. Examinem l’evolució de malgrat segons les propostes de la Lingüística Cognitiva i, concretament, la Teoria de la Gramaticalització, i les combinem amb els plantejaments de l’Anàlisi del Discurs, la Teoria de l’Argumentació i la Pragmàtica. La defensa del canvi lingüístic arrelat en l’ús, d’acord amb la Teoria de la Intersubjectivació, ens ajuda a revisar les …

Granulocyte-macrophage colony-stimulating factor induces cytokine secretion by human polymorphonuclear leukocytes.

1989

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known as an inducer of proliferation and functional activation of myeloid cells. This study was carried out to characterize the effects of GM-CSF on polymorphonuclear leukocytes (PMN) more extensively. Using Northern blot analysis, we show that PMN are able to accumulate mRNAs for different cytokines, including tumor necrosis factor-alpha (TNF-alpha); G-CSF, and M-CSF, all of which are involved in inflammation and hematopoiesis. Biological assays and immunoassays demonstrate that PMN translate these mRNAs, except TNF-alpha, into secretory proteins. However, the expression of these cytokines is dependent on stimulation by exogenous…

Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

2009

CD8 T-cells contribute to control of Mycobacterium tuberculosis infection, but little is known about the quality of the CD8 T-cell response in subjects with latent infection and in patients with active tuberculosis disease. CD8 T-cells recognizing epitopes from 6 different proteins of Mycobacterium tuberculosis were detected by tetramer staining. Intracellular cytokines staining for specific production of IFN-gamma and IL-2 was performed, complemented by phenotyping of memory markers on antigen-specific CD8 T-cells. The ex-vivo frequencies of tetramer-specific CD8 T-cells in tuberculous patients before therapy were lower than in subjects with latent infection, but increased at four months a…