Search results for "Riba"

Viral resistance in HCV infection.

2018

The introduction of new multi-genotypic direct acting antivirals (DAA) in clinical practice has revolutionized HCV treatment, permitting the achievement of >95% rates of sustained virological response in many patients. However, virological failures can occur particularly if the treatments are sub optimal and/or with too short duration. Failure is often associated with development of resistance. The wide genetic variability in terms of different genotypes and subtypes, together with the natural presence and/or easy development of resistance during treatment, are intrinsic characteristics of HCV that may affect the treatment outcome and the chances of achieving a virological cure. This review…

Clinical significance of detectable and quantifiable HCV RNA at the end of treatment with ledipasvir/sofosbuvir in GT1 patients

2018

Background & aims AASLD/IDSA treatment guidelines for hepatitis C virus (HCV) infection state that testing for quantitative HCV RNA can be considered at the end of antiviral treatment (EOT) with interferon-free regimens. However, it remains unclear how to respond to a detectable or even quantifiable HCV RNA result. The aim of this study was to analyse the frequency and predictive value of detectable and quantifiable HCV RNA results at the EOT in patients with HCV genotype 1 infection treated with ledipasvir (LDV) and sofosbuvir (SOF) ± ribavirin (RBV) in a large real-world cohort. Methods A retrospective analysis of the DHC-R (Deutsches Hepatitis C-Register, German Hepatitis C-Registry) coh…

Direct-acting antivirals and visceral leishmaniasis: a case report

2019

Abstract Background Visceral leishmaniasis is a vector-borne parasitic disease caused by protozoa belonging to the genus Leishmania. The clinical presentation of visceral leishmaniasis strictly depends on the host immunocompetency, whereas depressive conditions of the immune system impair the capability to resolve the infection and allow reactivation from sites of latency of the parasite. Case presentation We describe a case of visceral leishmaniasis (VL) that occurred in a patient with chronic hepatitis C treated with direct-acting antiviral drugs (DAA). The hypothesized mechanism is the alteration of protective inflammation mechanisms secondary to DAA therapy. Downregulation of type II an…

Daclatasvir-based regimens in HCV cirrhosis: experience from the Italian early access program

2019

AbstractWe reported the efficacy and safety data for daclatasvir (DCV)-based all-oral antiviral therapy in patients treated in the Italian compassionate-use program. 275 patients were included (202 male-73.5%, mean age: 57.4 years, 62 HIV-coinfected, 94 with recurrence of hepatitis C post-OLT). Forty-nine patients (17.8%) had Child-Pugh B, Genotype(G) distribution was: G1a:72 patients (26.2%), G1b:137 (49.8%); G3:40 (14.5%) and G4:26 (9.5%). Patients received DCV with sofosbuvir(SOF) (n = 221, 129 with ribavirin(RBV) or with simeprevir (SMV) or asunaprevir (ASU) (n = 54, 19 with RBV) for up to 24 weeks. Logistic regression was used to identify baseline characteristics associated with sustai…

Validación del cribado nutricional Malnutrition Screening Tool comparado con la valoración nutricional completa y otros cribados en distintos ámbitos…

2018

Resumen Introducción: los cribados son empleados para detectar el riesgo nutricional y permiten intervenir precozmente e influir en el pronóstico. La herramienta Malnutrition Screening Tool (MST) está validada en paciente hospitalizado y oncológico ambulatorio. Objetivo: analizar por ámbitos sociosanitarios y grupos etarios los cribados MST, Malnutrition Universal Screening Tool (MUST) y Mini Nutritional Assessment-Short Form (MNA-sf) respecto a la valoración nutricional completa (VNC) como patrón de referencia, y evaluar la utilidad del MST en aquellos ámbitos donde no está validado. Material y métodos: se han incluido 815 sujetos ambulatorios, hospitalizados e institucionalizados. Se les …

Add-On Peginterferon Alfa-2a Significantly Reduces HBsAg Levels in HBeAg-Negative, Genotype D Chronic Hepatitis B Patients Fully Suppressed on Nucleo…

2016

23 (36%) cases, respectively. Ribavirin (RBV) was used in 35% and 65% of the patients receiving SOF and DCV, respectively. Most of the patients were male (72%) and genotype 1b (81%). Median age was 59 years. Median baseline MELD and Child–Pugh (CPT) scores were 9 and 6, respectively. Among the patients with cirrhosis, 47% were CPT B/C. Tacrolimus was the immunosuppressant used in the majority of the patients (69%). At the beginning of therapy, 20 patients had ascites and 3 had hepatic encephalopathy (HE). Thirty-four patients completed the treatment course and 30 are still on therapy. End of treatment (EOT) response was 88% (30/34) and SVR12 was 83% (25/30). In patients receiving SMV+DCV±RB…

De novo biosynthesis of simple aromatic compounds by an arthropod ( Archegozetes longisetosus )

2020

The ability to synthesize simple aromatic compounds is well known from bacteria, fungi and plants, which all share an exclusive biosynthetic route—the shikimic acid pathway. Some of these organisms further evolved the polyketide pathway to form core benzenoids via a head-to-tail condensation of polyketide precursors. Arthropods supposedly lack the ability to synthesize aromatics and instead rely on aromatic amino acids acquired from food, or from symbiotic microorganisms. The few studies purportedly showing de novo biosynthesis via the polyketide synthase (PKS) pathway failed to exclude endosymbiotic bacteria, so their results are inconclusive. We investigated the biosynthesis of aromatic …

El cribado preoperatorio negativo mediante RT-PCR no garantiza la no infección por SARS-CoV-2

2023

5-6 gadīgu bērnu patstāvības sekmēšana vizuālajā mākslā

2021

Bakalaura darba tēma: 5 - 6 gadīgu bērnu patstāvības sekmēšana vizuālajā mākslā Darba autore: Dārta Logina Darba vadītājs: Docents Dr.paed. Dagnija Vigule Pētījuma mērķis: analizēt teorētisko literatūru, veikt pētījumu par patstāvības sekmēšanu 5-6 gadīgiem bērniem vizuālās mākslas nodarbībās. Darbs tika izstrādāts divās daļās. Teorētiskajā daļā tika analizētas pedagogu un psihologu atziņa par patstāvību un tās sekmēšanu vizuālās mākslas nodarbības 5 – 6 gadīgiem bērniem, kas balstās uz H. Helminga, D. Lieģeniece, B. Frīdenberga, V. Hibnere, G. Svence, A.Vorobjovs, Z.Sīmane, I. Kraģis, A.Špona, I. Kļava u.c autora atziņām. Pētījuma empīriskā daļa balstās uz praktisko pētījumu, kurā piedalīj…

Construcción y validación de un sistema de detección precoz de trastornos de desarrollo (SDPTD) en niños de 18, 24, y 36 meses

2013

En esta tesis se pretende contruir una herramienta de detección precoz que detecte cualquier alteración que se produzca en el desarrollo del niño como una medida preventiva de posibles trastornos posteriores más graves. En esta investigación se ha diseñado una herramienta basada en web y apoyada en videos para facilitar a las familias la administración. El sistema esta compuesto de 7 cuestionarios pero en esta tesis estan validados los 3 cuestionarios (18 meses, 24 meses y 36 meses). Los cuestionarios se pueden encontrar en: https://cudap.uv.es/ProyectoC/