Search results for "Ridge"

Biomarkers for glaucoma: from the lab to the clinic

2017

Glaucoma, a leading cause of irreversible blindness worldwide, is often not diagnosed until many years after disease onset. Early and objective diagnostic measures are yet missing. Besides the main risk factor, an elevated intraocular pressure (IOP), age, sex, and ethnicity are known to affect disease progression and severity. Furthermore, oxidative stress, elevated glutamate concentrations, and an autoimmune component are considered possible risk factors. We could identify several potential proteomic biomarkers in glaucoma and examine distinct changes in the glaucomatous human retina proteome. Using an experimental autoimmune glaucoma animal (EAG) model we could demonstrate an IOP-independ…

2-Alkenoyl Pyridine N-Oxides, Highly Efficient Dienophiles for the Enantioselective Cu(II)−Bis(oxazoline) Catalyzed Diels−Alder Reaction

2007

2-Alkenoyl pyridine N-oxides are introduced as a new kind of efficient dienophiles for the Cu(II)−bis(oxazoline) (BOX) catalyzed enantioselective Diels−Alder reaction affording higher reactivity and enantioselectivity (ee's up to 96%) than the corresponding nonoxidized 2-alkenoyl pyridines.

Rapid shifting of a deep magmatic source at Fagradalsfjall volcano, Iceland

2022

AbstractRecent Icelandic rifting events have illuminated the roles of centralized crustal magma reservoirs and lateral magma transport1–4, important characteristics of mid-ocean ridge magmatism1,5. A consequence of such shallow crustal processing of magmas4,5 is the overprinting of signatures that trace the origin, evolution and transport of melts in the uppermost mantle and lowermost crust6,7. Here we present unique insights into processes occurring in this zone from integrated petrologic and geochemical studies of the 2021 Fagradalsfjall eruption on the Reykjanes Peninsula in Iceland. Geochemical analyses of basalts erupted during the first 50 days of the eruption, combined with associate…

Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage

2021

The accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is required for most of these interactions. For example, HIV-1 Nef activates the tyrosine kinase Hck by tightly binding to its SH3 domain. An archetypal contact between a negatively charged SH3 residue and a highly conserved arginine in Nef (Arg77) plays a key role here. Combining structural analyses with functional assays, we here show that Nef proteins have also developed a distinct structural strategy—termed the "R-clamp”—that favors the formation …

One-year implant survival following lateral window sinus augmentation using plasma rich in growth factors (PRGF) : a retrospective study

2019

Background The aim of this study was to assess one-year implant survival after lateral window sinus augmentation using PRGF combined with various bone grafting materials. Material and Methods This was a retrospective chart review and radiographic analysis of patients that had undergone lateral window sinus augmentation with PRGF and had dental implants placed at least 6 months post augmentation. All implants included were followed up for at least one year after placement. Demographic, sinus and implant related characteristics (residual ridge height, sinus membrane perforation, type of graft material, implant length and width and ISQ at placement) were analyzed. Results A total of 31 patient…

2019

The preparation of unprecedented 6,12-disubstituted methanodibenzo[b,f][1,5]dioxocins from pyrrolidine catalyzed self-condensation of 2′-hydroxyacetophenones is herein described. This method provides easy access to this highly bridged complex core, resulting in construction of two C–O and two C–C bonds, a methylene bridge and two quaternary centers in a single step. The intricate methanodibenzo[b,f][1,5]dioxocin compounds were obtained in up to moderate yields after optimization of the reaction conditions concerning solvent, reaction times and the use of additives. Several halide substituted methanodibenzo[b,f][1,5]dioxocins could be prepared from correspondent 2′-hydroxyacetophenones.

Applicazione delle Linee guida italiane alle valutazioni di sicurezza strutturale del ponte Corleone sulla tangenziale di Palermo

2022

The "nominal life" of a large part of existing reinforced and prestressed concrete bridges, in Italy, is expiring, often in the absence of ordinary or extraordinary maintenance. Consequently, the Italian infrastructural network is in a critical phase, followed by the alarmed awareness of the public opinion, especially after the collapse of the Polcevera viaduct. Specific guidelines on risk classifi-cation, management, safety assessment, monitoring of existing bridges have been issued by the Superior Council of Public Works in 2020, to address the emergency. Between ‘50s and ‘70s of the last century, important examples of reinforced and prestressed concrete bridges were built in Italy by the…

Ecological Networks and Planning

2017

This chapter focuses on the regulation issue of the ecological networks/connections within planning instruments. In effect, the paradigm of ecological networks can be adopted within planning instruments to bridge the split existing in current development patterns between the use of the land and conservation of nature. About this issue, the work clearly explains the critical aspects, also referring to different ecological network models and specific local realities. In relation to this perspective, the most commonly adopted approach for the introduction of ecological networks into the planning process is the ecosystemic approach which, when applied to territory planning, shows it is particul…

Coulomb blockade thermometer: Tests and instrumentation

1998

Coulomb blockade thermometry (CBT) provides a simple method for absolute thermometry in every day laboratory use at cryogenic temperatures. CBT has been found insensitive to even high magnetic fields. We review the principles and the operation of CBT and the fabrication of the sensors, and present new data on radiation hardness and stability of the sensors. We describe the instrumentation of CBT in detail. We have developed two signal conditioning units for CBT measurements. One is a modified alternating current resistance bridge, a versatile laboratory instrument operating with a PC computer, and the other one is a simple stand-alone instrument for direct temperature reading. Test results …

MgO Magnetic Tunnel Junction Electrical Current Sensor With Integrated Ru Thermal Sensor

2013

Full Wheatstone bridge electrical current sensor incorporating 114 MgO-based magnetic tunnel junction elements (3 × 30 μm2) connected in series was produced for improved electrical robustness. To that end, magnetic tunnel junctions with R × A ~7 KΩ μm2 tunneling magnetoresistance of 200%, were produced. The sensor was designed with an integrated Ru thin film resistive thermal detector (RTD) for temperature drift monitoring and compensation. In order to achieve a full bridge signal, a U-shaped copper trace was placed under a printed circuit board (PCB) specifically designed for this type of device. The resulting device exhibit sensitivities of 63.9 V/Oe/A in a 75 Oe linear range biased with …