Search results for "Rini"
showing 10 items of 746 documents
Heteroreceptor-mediated modulation of noradrenaline and acetylcholine release from peripheral nerves
2006
诗歌用大自然的词汇唤醒生活：两个二十世纪的女诗人。陈敬容和阿尔达•梅丽尼(Shige yong daziran de cihui huanxing shenghuo:liangge ershishiji de nü shiren. Chen Jingrong he Aerda Melini. La…
2012
Le due poetesse, cinese una - Chen Jingrong, italiana l'altra - Alda Merini, vissute entrambe nel XX secolo, presentano delle esperienze di vita molto complesse in entrambi i casi. La loro poesia presenta poi delle inattese comunanze nella scelta delle parole che descrivono la natura. Il contributo mette in risalto questo aspetto attraverso il close reading e ne trae delle conclusioni interpretative.
GUARINO GUARINI E LA CHIESA DEI PADRI SOMASCHI A MESSINA
2016
Il progetto di Guarino Guarini per la chiesa dei Padri Somaschi di Messina costituisce uno dei problemi aperti della letteratura storiografica dedicata al celebre architetto modenese. La sua mancata realizzazione e, al contempo, le sue connotazioni ritenute ricorrentemente troppo “mature” per la fase iniziale della sua carriera, svoltasi a Messina negli anni 1657- 1662, hanno infatti indotto a sostanziali incertezze sulla sua collocazione cronologia e quindi sul suo effettivo ruolo nella concatenazione delle esperienze progettuali di Guarini, in merito soprattutto alla messa a punto delle sue singolari cupole a fasce incrociate. Questo contributo propone un risposta a tali irrisolte questio…
Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
2000
The basic symptoms of Alzheimer's dementia, i.e., a loss in cognitive function, are due to impaired nicotinic cholinergic neurotransmission. To compensate for this impairment by drug treatment, blockers of the acetylcholine-degrading enzyme acetylcholinesterase are applied, even though this approach obviously is prone to many side-effects, including those of muscarinic nature. We have recently described a novel class of nicotinic acetylcholine receptor ligands which, similar to the action of benzodiazepines on GABA(A) receptors, allosterically potentiate submaximal nicotinic responses. The sensitizing effect is a consequence of facilitated channel opening in the presence of allosterically p…
Influence of brine concentration on swelling pressure of pork meat throughout salting.
2009
Abstract The influence of sodium chloride on the water holding capacity of meat is well known and described in literature. An increase in water holding capacity is associated with an increase in the swelling pressure in the protein matrix. A novel device was used to measure the swelling pressure during brine salting of muscle cylinders (40 × 50 mm), in different NaCl brine concentrations (2.5 to 25%) over 6 days at 4 °C. Changes in meat composition, weight and height of non-constrained control samples were also measured. The aim of this work was to prove the feasibility of using the developed device in order to quantify the influence of the brine concentration on the magnitude of the swelli…
Atropine-resistant effects of the muscarinic agonists McN-A-343 and AHR 602 on cardiac performance and the release of noradrenaline from sympathetic …
1974
Abstract 1 The effects of 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343) and N-benzyl-3-pyrrolidyl acetate methobromide (AHR 602) on cardiac performance and noradrenaline release from terminal sympathetic fibres were measured in isolated perfused hearts of rabbits. 2 In the presence of sufficient atropine to block muscarinic receptors, high concentrations of McN-A-343 and AHR 602 caused no cardiac stimulation and there was no increase in the resting output of noradrenaline into the perfusates. 3 McN-A-343 and AHR 602 increased both the mechanical responses and the transmitter overflow evoked by electrical stimulation of the sympathetic nerves (SNS) but inhibi…
“AD HOC” MODIFIED CLAYS FOR BIOTECHNOLOGICAL APPLICATIONS
Nowadays, the scientific community has to face with cogent problems strictly linked to the improvement of quality of live. Among the different tasks to achieve the prefixed objective the focus has been put on the drug administration, i.e., attention has been paid to propose an appropriate solution to improve the performance of a drug delivery system and to eliminate both the side effect and drawbacks. With the aim to achieve the design, synthesis, and characterization of versatile systems, with peculiar characteristics, based on clays and clays modified with a biocompatible surfactant, able to adsorb and release organic substances of pharmaceutical interest the present PhD thesis has been u…
Specific recommendations for PROs and HRQoL assessment in allergic rhinitis and/or asthma: a GA(2)LEN taskforce position paper
2010
The GA(2)LEN taskforce on Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HRQoL) published in 2009 a position paper concerning PROS and HRQoL assessment in clinical trials on allergy. Because of the specificity of this topic in asthma and rhinitis, specific recommendations are needed. The aim of this position paper is to define PROs and their meaning in asthma and rhinitis research, explore the available tools to provide criteria for a proper choice, identify patient-related factor which could influence PROs assessment, define specific recommendations for assessment, analysis and results spreading, underline the unexplored areas and unmet needs. PROs assessment is gaini…
Il nobile casato dei Ventimiglia e Donna Felice Ventimiglia Barberini
2017
Nella prima parte del saggio (R.F. Margiotta, Il nobile casato dei Ventimiglia dalla Liguria alla Sicilia) si delinea la storia dei Ventimiglia, provenienti dalla Liguria, insediatisi in Sicilia sin dal Duecento, da Francesco I a Francesco IV Rodrigo, padre di Felice Ventimiglia, e ci si sofferma sulle opere più rappresentative da loro commissionate. Nella seconda parte (M.C. Di Natale, Felice Ventimiglia Barberini dal principato di Castelbuono a Roma) si prende in esame la figura di donna Felice Ventimiglia e se ne ripercorrono le vicende della vita attraverso due significativi documenti: l'inventario dotale della nobildonna, stilato nel 1693, in occasione delle nozze con il principe di pa…
Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies …
1996
There is now increasing evidence that hyperresponsiveness towards intestinal flora is a crucial event in the pathogenesis of inflammatory bowel disease (IBD). In support of this hypothesis, we recently described in humans that tolerance exists towards indigenous intestinal flora but is broken in active IBD lesions. In the present study, we have attempted to transfer this model into mice from different genetic backgrounds (BALB/c, SJL/J, C3H/HeJ). We found that mononuclear cells from spleen, small bowel and large bowel of mice do not proliferate, i.e. are tolerant when exposed to bacterial sonicates derived from autologous intestine (BsA) but do proliferate, i.e. are immune when exposed to b…