Search results for "Rome"
showing 10 items of 12914 documents
Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Ne…
2021
The mitochondrial serine protease HTRA2 has many versatile biological functions ranging from being an important regulator of apoptosis to being an essential component for neuronal cell survival and mitochondrial homeostasis. Loss of HTRA2 protease function is known to cause neurodegeneration, whereas overactivation of its proteolytic function is associated with cell death and inflammation. In accordance with this, our group verified in a recent study that the synthetic peptide ASGYTFTNYGLSWVR, encoding the hypervariable sequence part of an antibody, showed a high affinity for the target protein HTRA2 and triggered neuroprotection in an in vitro organ culture model for glaucoma. To unravel t…
4812 - A0028 Gangliosides in the retina: a comparative inventory with brain and other ocular structures
2016
Purpose: Gangliosides (GG) make an extremely diverse family of glycosphingolipids particularly abundant in the brain and neural tissues. While it is known that alterations in GG metabolism are associated with visual defects, the precise biological roles of these compounds in the retina are still largely unknown. In this context, we performed an exhaustive inventory and thorough characterization of the human eye GG aiming to reveal specificities and common features of the retina compared to other ocular tissues and brain.Methods: Retina, RPE/Choroid, ciliary body, optic nerve and brain samples were collected from deceased human donors (N=7). GG were extracted and analysed by a comprehensive …
Open Source & Shared Urban Design Platform
2017
Il progetto “ROMA 20-25 Nuovi cicli di vita per la Metropoli”, promosso dall’Assessorato alla Trasformazione Urbana del Comune di Roma e dal MAXXI, Museo Nazionale delle Arti del XXI secolo, ha chiamato ventiquattro scuole di architettura, università italiane e internazionali, a interpretare il presente urbano di Roma e immaginarne il futuro attraverso un workshop internazionale di progettazione e una mostra, coinvolgendo le Unità di Ricerca del PRIN “RE-CYCLE Italy. Nuovi cicli di vita per architetture e infrastrutture della città e del paesaggio”. Il contributo dell'Unità di Ricerca dell’Università di Palermo "Re-forming verso la Agri/FabCity per Roma 20-25" è stata l'occasione per sperim…
Kuparin, hopean ja palladiumin talteenotto piirilevyjätteestä
2017
Tutkielmassa käsitellään rikkihapon käyttöä sähkö- ja elektroniikkaromuun kuuluvan piirilevyjätteen liuotuksessa ja rikkihappoon liuenneiden metallien talteenottoa erilaisin menetelmin. Sähkö- ja elektroniikkaromu on pian maailman suurimmaksi kasvava jätevirta, jolla on sekä ympäristöllisiä että taloudellisia vaikutuksia, jos romun sisältämiä metalleja ei saada kierrätettyä. Elektroniikkalaitteiden piirilevyt sisältävät noin 60 % metalleja, joiden talteenottamiseksi on lähiaikoina tehty paljon tutkimusta. Piirilevyjen sisältämiä arvokkaita metalleja ovat erityisesti kulta, hopea, palladium ja platina. Rikkihappo on yleisin teollisuudessa käytetty happoliuotin, …
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
2015
Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However…
SINDROME DA MICRODELEZIONE 17q21.31: DESCRIZIONE DI UN CASO CON ELEVATA ESPRESSIVITA' CLINICA
2011
La sr da microdelezione 17q21.31(prevalenza 1:16.000)è un disordine genomico di recente identificazione.I segni clinici comprendono: ritardo mentale e di sviluppo, ipotonia, dismorfismi faciali, voce nasale, dita affusolate, cardiopatia, anomalie cerebrali, convulsioni, anomalie renali ed urogenitali, iperlassità articolare, ipoacusia trasmissiva, anomalie dentarie, deformità del piede e della colonna, strabismo e ipermetropia.La diagnosi è confermata dal riscontro,all’analisi molecolare,della delezione della regione critica, che si estende per 424 kb in 17q21.31 ed include almeno sei geni, tra cui MAPT, altamente espresso nell’encefalo e coinvolto in numerose patologie neurodegenerative. D…
Stiffness Estimation and Adaptive Control for Soft Robots
2022
Nonostante la sorprendente crescita nello sviluppo dei robot ispirati alla natura, tra cui i cosiddetti soft robot, il potenziale di questi sistemi, che hanno intrinseche capacità di adattamento, non è ancora stato sfruttato a pieno. La ricerca ha principalmente considerato il controllo in retroazione della posizione dei giunti del robot, lasciando la gestione della cedevolezza di questi ultimi ancora in anello aperto. Peraltro, le attuali limitazioni nel processo di produzione degli attuatori a cedevolezza variabile e l'inevitabile variabilità nel tempo degli elementi elastici costitutivi, i quali sono soggetti ad usura e deformazione plastica, rendono il problema della determinazione prec…
Un dieu peut-il mourir ? Enquête sur la fin des cultes dans l’Antiquité gréco-romainedirigé par Karin Mackowiak et Christian Stein
2018
Ķīmisko elementu saturs dažādos rīsos
2018
Ķīmisko elementu saturs dažādos rīsos. Lāma E., zinātniskais vadītājs Dr. ķīm., doc. Rudoviča V. Bakalaura darbs, 43 lappuses, 13 attēli, 6 tabulas, 34 literatūras avoti, 10 pielikumi. Latviešu valodā. Pētījumā ķīmisko elementu (Zn, Mn, Cu, Se, Sr, Ba, Cd, As, Pb) saturs rīsu paraugos tika noteikts ar induktīvi saistītās plazmas masspektrometrijas metodi, liesmas un elektrotermālās atomabsorbciometrijas analīzes metodēm. Tika izvērtēta elementu masas daļa rīsu paraugos atkarībā no to klasifikācijas, apstrādes veida, ievākšanas valsts.
The evolution and ecology of multiple antipredator defences
2023
Prey seldom rely on a single type of antipredator defence, often using multiple defences to avoid predation. In many cases, selection in different contexts may favour the evolution of multiple defences in a prey. However, a prey may use multiple defences to protect itself during a single predator encounter. Such “defence portfolios” that defend prey against a single instance of predation are distributed across and within successive stages of the predation sequence (encounter, detection, identification, approach (attack), subjugation and consumption). We contend that at present, our understanding of defence portfolio evolution is incomplete, and seen from the fragmentary perspective of speci…