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showing 10 items of 9311 documents
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
1989
Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
1989
Abstract Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
CD49d Expression Identifies a Chronic Lymphocytic Leukemia (CLL) Subset with High Levels of Circulating CD34 +Cells Co-Expressing Endothelial Cell Ma…
2009
Abstract Abstract 2329 Poster Board II-306 Introduction: In chronic lymphocytic leukemia (CLL), CD49d, often in association with CD38, has been shown to mark a disease subset with poor prognosis. Functionally, both molecules act as counter-receptors for surface structures (i.e. VCAM-1/CD106 and CD31) usually expressed by the endothelial/stromal component of tumor micro-environment. We have recently identified a micro-environmental circuitry which involves CD38 triggering, and eventually determines an enrichment of the VCAM-1/CD106-expressing endothelial component detected in the context of CLL infiltrates found in bone marrow biopsies. Data was also provided that CD49d/VCAM-1 interactions a…
How to address the mental health of migrant and refugee population in Europe? An integrated shift in health and social care services - MigHealthCare …
2020
Introduction Health and social care services across Europe are facing diverse challenges meeting the specific needs of migrants and refugees [1]. In this regard, vulnerable migrants fall outside mental healthcare services [2]. Based on this, Mig-Healthcare project, funded by the European Commission, explores the health needs of the migrant population in an effort to strengthen EU community-based services. Methods A total of 20 focus groups and 19 individual interviews were conducted between November 2017 and April 2018 with different stakeholders involved in the provision of health and social care to the migrant population in the 10 countries (Greece, France, Malta, Germany, Austria, Italy,…
Evaluation of Bone Marrow CD8+ tissue-Resident Memory T Cells in Multiple Myeloma
2019
Background: CD8+ T cell responses are an essential component of the adaptive immune system. After resolution of infection a small population of memory cells is formed. In relation to circulatory patterns, different subsets of memory CD8+ T cells can be identified: the central memory (CM) and the effector memory T cells (EM) (Martin MD, et al., Front Immunol. 2018). In addition, it has been described a subset of resident memory T cells (TRM) permanently living in peripheral tissues, including the bone marrow (BM) (Di Rosa F., et al., Nat Rev Immunol. 2016). It is conceivable that these cells can contribute to the defence toward haematological tumours infiltrating the BM. Therefore, we perfor…
Kompetencje medialne, informacyjne i cyfrowe a kształcenie w społeczeństwie informacyjnym
2020
Funkcjonowanie człowieka w rzeczywistości medialnej jest jedną z głównych umiejętności, którą powinien dysponować w życiu dorosłym, i która powinna być kształtowana od najmłodszych lat. Istnieje wiele problemów związanych z miejscem kompetencji i umiejętności w edukacji człowieka. Począwszy od kwestii rozróżnienia kompetencji medialnych, cyfrowych, informacyjnych przez dyskusję, czy kompetencje te są zadaniem edukacji czy pedagogiki medialnej, aż do tego, kto ma realizować tę edukację i czy te osoby, grupy zawodowe są do tego przygotowane. Artykuł jest próbą przeglądu definicji dotyczących funkcjonowania człowieka w społeczeństwie informacyjnym oraz ma na celu podkreślenie konieczności wspó…
Kształtowanie projektowo-technologicznej kultury przyszłych nauczycieli w wielokulturowym środowisku
2017
W artykule rozpatruje się problem kształtowania projektowo-technologicznej kultury studentów uczelni pedagogicznych. Podkreśla się, że ważnym zadaniem nauki pedagogicznej jest opracowanie systemu modernizacji edukacji uniwersyteckiego kształcenia poprzez pryzmat europejskiej globalizacji w wielokulturowym środowisku
Relaxion fluctuations (self-stopping relaxion) and overview of relaxion stopping mechanisms
2020
Journal of high energy physics 2005(5), 80 (2020). doi:10.1007/JHEP05(2020)080
Complete One-Loop Renormalization of the Higgs-Electroweak Chiral Lagrangian
2018
The electroweak sector of the Standard Model can be formulated in a way similar to Chiral Perturbation Theory (ChPT), but extended by a singlet scalar. The resulting effective field theory (EFT) is called Higgs-Electroweak Chiral Lagrangian (EWCh$\mathcal{L}$) and is the most general approach to new physics in the Higgs sector. It solely assumes the pattern of symmetry breaking leading to the three electroweak Goldstone bosons (i.e. massive $W$ and $Z$) and the existence of a Higgs-like scalar particle. The power counting of the EWCh$\mathcal{L}$ is given by a generalization of the momentum expansion of ChPT. It is connected to a loop expansion, making the theory renormalizable order by ord…