Search results for "S1"
showing 10 items of 755 documents
In Silico Design, Synthesis and Biological Evaluation of Anticancer Arylsulfonamide Endowed with Anti-Telomerase Activity
2022
Telomerase, a reverse transcriptase enzyme involved in DNA synthesis, has a tangible role in tumor progression. Several studies have evidenced telomerase as a promising target for developing cancer therapeutics. The main reason is due to the overexpression of telomerase in cancer cells (85–90%) compared with normal cells where it is almost unexpressed. In this paper, we used a structure-based approach to design potential inhibitors of the telomerase active site. The MYSHAPE (Molecular dYnamics SHared PharmacophorE) approach and docking were used to screen an in-house library of 126 arylsulfonamide derivatives. Promising compounds were synthesized using classical and green methods. Com…
FROM PRODUCER TO CONSUMER – RELATIONS BETWEEN PRICES OF SELECTED PRODUCTS ON THE AGRI-FOOD MARKET
2019
The food supply chain is characterized by a large diversity of entities comprising it, combining actions taken by individual links, starting with the producer on the consumer. The primary goal of the smooth functioning of the food supply chain is to ensure satisfaction of buyers, while profiting by companies participating in the flow of products. The primary aim of the efficient functioning of the food supply chain is to ensure satisfaction of buyers, while profiting by companies participating in the flow of products. Changes occurring in agricultural production, often cyclical, are transferred to individual links in the supply chain. This phenomenon is visible in changes in the level of pr…
Surface homeomorphisms with zero dimensional singular set
1998
We prove that if f is an orientation-preserving homeomorphism of a closed orientable surface M whose singular set is totally disconnected, then f is topologically conjugate to a conformal transformation.
Transitioning towards a Sustainable Wellbeing Economy—Implications for Rural–Urban Relations
2021
This article focuses on the question of how a shift from a narrow economic perspective to a wider sustainable wellbeing focus in regional development strategies and actions might change rural–urban relations. A brief review of relevant research and discourses about economic development models provides the foundation for the analysis. The review leads to the development of an analytical framework that puts the notion of sustainable wellbeing at its center. The criteria included in the analytical framework are then used to assess the current situation, challenges and perceived ways forward based on data and analyses from 11 European regions. The focus of the analysis is on different exp…
SwiftUI salīdzinājums ar iOS12 skatu izveides tēliem iOS lietotņu izstrādē
2020
Viedierīču lietošana ikdienā ir kļuvusi par neatņemamu sastāvdaļu mūsu ikdienā. Galvenais saskares punkts starp programmatūru un tās lietotāju ir lietotāja saskarne. Viedierīcē redzamā saskarne sastāv no daudz dažādiem skatiem, kuru izstrādi iespējams veikt dažādos veidos. Saskarnes izstrāde ir ļoti svarīga, jo tieši tā piesaista lietotāju uzmanību, ļauj viegli un intuitīvi lietot programmatūru un veicina atkārtotu atgriešanos tajā. Līdz 2019. gadam, kad augstākā iOS operētājsistēmas versija bija 12, skatu būve balstījas uz UIKit bibliotēku un diviem galvenajiem paņēmieniem – skatus izstrādājot ar saskarnes būvētāju un skatu veidojot no pirmkoda. Skatu izstrādājot ar saskarnes būvētāju tiek…
A Viscoelastic Model for the Long-Term Deflection of Segmental Prestressed Box Girders
2017
Most of segmental prestressed concrete box girders exhibit excessive multidecade deflections unforeseeable by past and current design codes. To investigate such a behavior, mainly caused by creep and shrinkage phenomena, an effective finite element (FE) formulation is presented in this article. This formulation is developed by invoking the stationarity of an energetic principle for linear viscoelastic problems and relies on the Bazant creep constitutive law. A case study representative of segmental prestressed concrete box girders susceptible to creep is also analyzed in the article, that is, the Colle Isarco viaduct. Its FE model, based on the aforementioned energetic formulation, was succ…
Cytokine Polymorphism in Takotsubo Cardiomyopathy
2014
IMIN11. Cytokine Polymorphism in Takotsubo Cardiomyopathy P. Di Gangi1, L. Scola1, S. Giambanco1, M. Bova1, G. Santini1, L. Vaccarino1, C. R. Balistreri1, D. Lio1, P. Assennato1, S. Novo1, G. Novo1 1University of Palermo, Palermo, Italy Background: Takotsubo (TT) cardiomyopathy is characterised by an acute left ventricular dysfunction triggered by emotional or physical stresses. Clinically, the syndrome is characterised by acute symptoms mimicking acute infarction without relevant electrocardiographic and biochemical markers of myocardial damage changes. Stressful events inducing an excess catecholamine release and myocardial β-adrenergic receptors (β-AR) seem to play a major role in TT. Ac…
Airborne birch pollen in Poland and Latvia in the light of data obtained from aerobiological monitoring and tauber traps in relation to mean air temp…
2012
Birch pollen contains allergens belonging to those with the strongest allergenic properties. In order to trace pollen season patterns of this taxon and pollen annual sums at a wider regional scale, cooperation was established with the University of Latvia in Riga (Latvia). A comparison of the results obtained in the years 2003-2008 in Lublin and in Riga, using volumetric samplers, shows that there was a similar trend in the abundance of birch pollen. The highest sums were noted at both sites in 2003. In all the study years, more birch pollen grains were recorded in Lublin than in Riga, on the average by 7110. The birch pollen seasons started earlier in Lublin than in Riga, on the average by…
Multiscale modeling of polycrystalline materials: A boundary element approach to material degradation and fracture
2015
Abstract In this work, a two-scale approach to degradation and failure in polycrystalline materials is proposed. The formulation involves the engineering component level (macro-scale) and the material grain level (micro-scale). The macro-continuum is modeled using a three-dimensional boundary element formulation in which the presence of damage is formulated through an initial stress approach to account for the local softening in the neighborhood of points experiencing degradation at the micro-scale. The microscopic degradation is explicitly modeled by associating Representative Volume Elements (RVEs) to relevant points of the macro continuum, for representing the polycrystalline microstruct…
Quantifying the Potential Economic Benefits of Flexible Industrial Demand in the European Power System
2018
The envisaged decarbonization of the European power system introduces complex techno-economic challenges to its operation and development. Demand flexibility can significantly contribute in addressing these challenges and enable a cost-effective transition to the low-carbon future. Although extensive previous work has analyzed the impacts of residential and commercial demand flexibility, the respective potential of the industrial sector has not yet been thoroughly investigated despite its large size. This paper presents a novel, whole-system modeling framework to comprehensively quantify the potential economic benefits of flexible industrial demand (FID) for the European power system. This …