Search results for "S2"
showing 10 items of 200 documents
Role of the NF-kB pathway and nitric oxide in mammary gland involution after weaning. Implications in breast cancer
2013
INTRODUCCIÓN La glándula mamaria es un órgano dinámico que alcanza su máximo desarrollo funcional con la lactancia, momento en el cual, a través de la producción de leche, aporta nutrientes y protección inmunológica a las crías de los mamíferos. Cuando la lactancia finaliza con el destete, el exceso de tejido glandular debe desaparecer y la glándula sufre una extensa remodelación hasta alcanzar nuevamente un estado pre-gestacional, preparada para un nuevo ciclo. La involución del tejido mamario es un proceso complejo durante el cual se suceden de forma coordinada una serie de eventos como la muerte de las células epiteliales secretoras, la proliferación de tejido adiposo circundante y la re…
Ohjelmointisatukirjat
2015
Tässä tutkielmassa käsitellään ohjelmoinnin opettamista lapsille satukirjojen avulla. Tutkielmassa tarkastellaan syksyllä 2016 voimaan astuvan opetussuunnitelman oh- jelmoinnin opettamisen tavoitteiden toteutumista kahdessa suomenkielisessä ohjelmointisa- tukirjassa. This thesis is about teaching computer programming for children with fairy tale books. The study examines added programming-related objectives of the new Finnish school system curriculum, which will come into operation in Autumn 2016. This study seeks imple- mentations of these programming-related objectives in two of the children’s storybooks avai- lable in Finnish.
Perception of pathogenic or beneficial bacteria and their evasion of host immunity: pattern recognition receptors in the frontline
2015
International audience; Plants are continuously monitoring the presence of microorganisms to establish an adapted response. Plants commonly use pattern recognition receptors (PRRs) to perceive microbe- or pathogen-associated molecular patterns (MAMPs/PAMPs) which are microorganism molecular signatures. Located at the plant plasma membrane, the PRRs are generally receptor-like kinases (RLKs) or receptor-like proteins (RLPs). MAMP detection will lead to the establishment of a plant defense program called MAMP-triggered immunity (MTI). In this review, we overview the RLKs and RLPs that assure early recognition and control of pathogenic or beneficial bacteria. We also highlight the crucial func…
Strongly Coupled Coherent Phonons in Single-Layer MoS 2
2019
We present a transient absorption setup combining broadband detection over the visible-UV range with high temporal resolution ($\sim$20fs) which is ideally suited to trigger and detect vibrational coherences in different classes of materials. We generate and detect coherent phonons (CPs) in single layer (1L) MoS$_2$, as a representative semiconducting 1L-transition metal dichalcogenide (TMD), where the confined dynamical interaction between excitons and phonons is unexplored. The coherent oscillatory motion of the out-of-plane $A'_{1}$ phonons, triggered by the ultrashort laser pulses, dynamically modulates the excitonic resonances on a timescale of few tens fs. We observe an enhancement by…
Dynamics of hydrofracturing and permeability evolution in layered reservoirs
2015
International audience; A coupled hydro-mechanical model is presented to model fluid driven fracturing in layered porous rocks. In the model the solid elastic continuum is described by a discrete element approach coupled with a fluid continuum grid that is used to solve Darcy based pressure diffusion. The model assumes poro-elasto-plastic effects and yields real time dynamic aspects of the fracturing and effective stress evolution under the influence of excess fluid pressure gradients. We show that the formation and propagation of hydrofractures are sensitive to mechanical and tectonic conditions of the system. In cases where elevated fluid pressure is the sole driving agent in a stable tec…
Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis
2019
Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to inflammatory lesions. These extremely plastic cells respond to extracellular signals which cause epigenomic changes that define their pathogenic phenotype. Here, we interrogated how DNA methylation alterations in RA monocytes are determined by extracellular signals. Methods: High-throughput DNA methylation analyses of patients with RA and controls and in vitro cytokine stimulation were used to investigate the underlying mechanisms behind DNA methylation alterations in RA as well as their relationship with clinic…
Cryopreservation of Hazelnut (Corylus avellana L.) Axillary Buds from In Vitro Shoots Using the Droplet Vitrification Method
2021
Cryopreservation by droplet vitrification was applied to hazelnut (Corylus avellana L.). axillary buds of the Italian cultivated variety Tonda Gentile Romana, which were collected from in vitro growing shoots, immersed in ice cooled PVS2 or PVS3 for 60 or 90 min, then transferred to a droplet of vitrification solution, placed on a strip of aluminium foil, and plunged into liquid nitrogen (LN). Additionally, the effect on the recovery of the mother plant after cryopreservation was evaluated, following a cold pre-treatment at 4 °C for 3 months. The highest regrowth percentage (56.7%) was obtained after applying PVS3 for 60 min, while the application of PVS2 for the same amount of time reduced…
Sulfonilurea preparātu farmakoģenētika cukura diabēta ārstēšanā
2015
Darba aktualitāte: Otrā tipa cukura diabēta (2TCD) prevalence pieaug gan Latvijas, gan pasaules mērogā. Pacientiem ir nepieciešama personalizēta pieeja, kas labāk ļautu sasniegt terapijas mērķi un izvairīties no komplikācijām. Sulfonilurea (SU) preparāti ir viena no visbiežāk izmantotajām perorālo antidiabētisko preparātu klasēm, tāpēc ir būtiski apzināt šo preparātu individuālos efektus. Pētījuma mērķis: Noskaidrot, vai SU preparātu farmakoģenētika ietekmē 2TCD pacientu ārstēšanas rezultātu. Metodes un materiāli: Longitudinālā prospektīvā pētījumā tika iesaistīti 315 2TCD pacienti, retrospektīvi tika iesaistīti 162, no kuriem kopumā sulfonilurea preparātus bija lietojuši 162, atlases kritē…
DNA integrity in diagnosis of premalignant lesions
2020
Background Carcinogenesis is a dynamic process which traditional biopsying can not keep up with. Saliva as fluid in the vicinity of the tumor can offer better insights to this process. This study aimed to identify the accuracy of salivary DNA integrity index in differentiating between oral premalignant lesions and oral cancer. Material and Methods This phase II diagnostic test accuracy study included 93 patients divided into three groups: 30 oral cancer patients, 33 patients with oral premalignant lesions divided into 21 oral lichen planus patients and 12 patients with leukoplakia and 30 normal individuals who acted as controls. Oral rinse was collected from all participants and they all un…
UTTAL AV S2-FINSKA MED FOKUS PÅ SVENSKSPRÅKIGA TALARE
2016
I undersökningen analyseras 11 inföddliknande S2-talares uttal av finska. Sex av talarna har finlandssvenska som S1, fem av talarna har sverigesvenska, tyska, franska, ryska resp. spanska som S1. Talarnas uttal undersöktes dels genom ett test med finskspråkiga lyssnare (n=93), dels genom att S2-talarnas uttal jämfördes akustiskt med uttalet hos talare med finska som S1. Vidare jämfördes de finlandssvenska talarnas uttal av finska och svenska. Resultaten visar att finlandssvenska talare skiljer sig som grupp från infödda finskspråkiga talare och från talare med ett annat S1 än finlandssvenska. De flesta finlandssvenskar bröt mycket svagt. Stavelselängderna och intonationen i långa ord orsaka…