Search results for "S2"
showing 10 items of 200 documents
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of …
1999
Aims/hypothesis. The aim of this study was to screen part of the putative promoter sequence in addition to 14 potential phosphotyrosine residues of human IRS-2 for genetic variability which might cause changes in protein expression or function. Furthermore, the potential impact on insulin secretion and sensitivity of a previously identified IRS-2 variant (Gly1057Asp) was analysed Methods. The screenings were carried out by the SSCP-heteroduplex technique on DNA from Type II (non-insulin-dependent) diabetic patients. The impact of the Gly1057Asp variant was analysed in four glucose-tolerant Scandinavian study groups. Results. The results showed no nucleotide substitutions in the promoter seq…
Competitive interaction between chronic obstructive pulmonary disease and CHA2DS2-VASc score in predicting incident atrial fibrillation
2018
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality, and an emerging risk factor for atrial fibrillation (AF). CHADS2 and CHA2DS2-VASc scores are significantly associated with incident AF independently of other risk factors. The aim of this study was to demonstrate a possible interaction between COPD and CHA2DS2-VASc in predicting incident AF. Methods: This observational prospective cohort study included 4322 Caucasians with cardiovascular risk factors, stratified by CHA2DS2-VASc score (> 2 vs < 2) and presence/absence of COPD. To detect AF appearance, patients underwent, every 6 months, physical examination, standard 12‑lead electrocardiog…
Taste receptor polymorphisms and longevity: a systematic review and meta-analysis
2020
AbstractBitter taste receptors (TAS2R) are involved in a variety of non-tasting physiological processes, including immune-inflammatory ones. Therefore, their genetic variations might influence various traits. In particular, in different populations of South Italy (Calabria, Cilento, and Sardinia), polymorphisms of TAS2R16 and TAS238 have been analysed in association with longevity with inconsistent results. A meta-analytic approach to quantitatively synthesize the possible effect of the previous variants and, possibly, to reconcile the inconsistencies has been used in the present paper. TAS2R38 variants in the Cilento population were also analysed for their possible association with longevi…
The polarization of European agriculture: spatial and dynamic features within a non parametric framework
2009
We present a study of the polarization of European agriculture at NUTS2 regional level. The analysis of selected indicators focuses on spatial and dynamic features of distributions. We make use of the non parametric technique of stochastic kernel which allows to explore the features of a whole distribution and to point out the clustering of statistical units.
Stochastic kernel and conditioning schemes: a study about the influence of spatial factor on agriculture of EU NUTS2
2009
Besides to be an useful methodology for the detection of distribution dynamics of indicators, stochastic kernel has been generalized to a regression-like rationale (Quah, 1997). The latter allows to determine how a distribution is influenced by a "factor", through a "conditioning scheme" which is a set of rules stating how the original distribution is altered in order to obtain its "conditioned" version. This paper aims to study the influence of the "spatial factor" on distributions of selected agriculture impact indicators across EU NUTS2. The present work offers an empirical analysis of dynamics of selected indicators of agriculture across NUTS2. Our scope is to give an overlook of EU ter…
QUANTIFICATION OF GENETIC VARIANTS OF CASEINS IN MILK OF GIRGENTANA GOAT BREED
2013
In the milk of ruminants, more than 95% of proteins are synthesized by six structural genes, four caseins (alphas1, beta, alphas2 and κ-caseins) and two whey proteins (alpha-lactalbumin and beta-lactoglobulin). Goat casein genes have been found to show high polymorphism, which influences not only the quantity of casein in milk but also the structural and nutritional characteristics and technological properties of milk. The aim of this work was to separate and quantify the most common allelic variants of caseins in milk of Girgentana goat breed, a Sicilian autochthonous breed, and to evaluate the effect of casein polymorphisms on casein content. The alleles at different casein genes were det…
Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception
2020
AbstractWe investigated potential SARS-CoV-2 tropism in human endometrium by single-cell RNA-sequencing of viral entry-associated genes in healthy women. Percentages of endometrial cells expressing ACE2, TMPRSS2, CTSB, or CTSL were <2%, 12%, 80%, and 80%, respectively, with 0.7% of cells expressing all four genes. Our findings imply low efficiency of SARS-CoV-2 infection in the endometrium before embryo implantation, providing information to assess preconception risk in asymptomatic carriers.
Anti-mikrobiālās plānās kārtiņas: izgatavošanas tehnoloģija un īpašību noteikšana.
2022
Šī pētījuma galvenais mērķis ir izstrādāt plānās kārtiņas pārklājumu ar anti-mikrobiālām īpašībām. Šim mērķim tika pētīts volframa oksīda un vara kombinētas plānās kārtiņas pārklājums uz PET substrāta, kura struktūras parametru pamatā ir caurspīdīgs ap 120 nm biezs volframa oksīda slānis ar tam virsū uzklātu 20 nm vara slāni, kas, savukārt, ir apsegts ar 120 nm volframa oksīda slāni – WOx/Cu/WOx. Anti-mikrobiālo efektu noteikšanai tika adaptētas testēšanas metodoloģijas JIS Z 2801 “Antimicrobial products-Test for antimicrobial activity and efficacy” (Association JS 2001) un ES ISO 22196 “Measurment of antibacterial activity on plastic surfaces” (ES ISO 22196). Testēšana tika veikta ar E.col…
Contributo para o estudo psicométrico da versão portuguesa do Cuestionario de Satisfacción Laboral S20/23
2010
Job satisfaction is understood through its dual role on organization productivity and employees achievement (Smith, 1998). The use of instruments to measure it in Portugal, has been the subject of several studies, such as the adaptation of the Cuestionario de Satisfacción Laboral S20/23 (Meliá & Peiró, 1989) to Portuguese population carried out by Pocinho and García (2008). This study is a further contribution to the study of the psychometric qualities of this instrument. The results on a sample of 136 Portuguese employees show that the questionnaire presents the adequate requirements of internal consistency (.95), test-retest reliability, and convergent validity (correlation of .84 with th…
Carotid plaque detection improves the predictve value of CHA2DS2-VASc score in patients with non-valvular atrial fibrilation: The ARAPACIS Study
2017
Abstract Background and aims Vascular disease (VD), as assessed by history of myocardial infarction or peripheral artery disease or aortic plaque, increases stroke risk in atrial fibrillation (AF), and is a component of risk assessment using the CHA 2 DS 2 -VASc score. We investigated if systemic atherosclerosis as detected by ultrasound carotid plaque (CP) could improve the predictive value of the CHA 2 DS 2 -VASc score. Methods We analysed data from the ARAPACIS study, an observational study including 2027 Italian patients with non-valvular AF, in whom CP was detected using Doppler Ultrasonography. Results VD was reported in 351 (17.3%) patients while CP was detected in 16.6% patients. Ad…