Search results for "SAC"

Hysteresis Model of Unconscious-Conscious Interconnection: Exploring Dynamics on m-Adic Trees

2015

The theoretical model outlined in this paper, has been experimentally validated by: H. Kim ,J-Y. Moon ,G.A. Mashour & U. Lee, ''Mechanisms of hysteresis in human brain networks during transitions of consciousness and unconsciousness: Theoretical principles and empirical evidence'', PLOS-Computational Biology, August 30, 2018, https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006424; International audience; In this brief note, we focus attention on a possible implementation of a basic hysteretic pattern (the Preisach one), suitably generalized, into a formal model of unconscious-conscious interconnection and based on representation of mental entities by m-adic numbers. …

Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen.

1993

The polyclonal stimulation of T cells by bacterial superantigens is involved in the pathogenesis of the toxic shock syndrome in certain staphylococcal and streptococcal infections. Here we describe the onset and kinetics of superantigen-induced cytokine production in situ in spleens of normal BALB/c mice monitored at the level of cytokine mRNA expression by in situ hybridization. Messenger RNAs for interleukin 2 (IL-2), interferon gamma, and tumor necrosis factors (TNF) alpha and beta were not expressed at detectable levels in spleens of unstimulated animals but became visible already 30 min after intraperitoneal application of 50 micrograms staphylococcal enterotoxin B. All mRNA levels sho…

Chemotherapy with Idarubicin, Ara-C,VP-16, Amsacrine, Followed by G-CSF and Maintenance Immunotherapy with Interleukin-2 for Patients with High-Risk …

1998

To improve the complete remission (CR) rate and to prolong CR duration in patients with advanced MDS, AML evolving from MDS, and secondary AML, a phase-III trial of aggressive chemotherapy followed by G-CSF was initiated in January 1992. Pts. achieving a CR were randomized to receive either high-dose or low-dose IL-2 to evaluate the potential of this cytokine to eliminate residual leukemic cells and to prolong the CR duration.

Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.

2015

Human group 1 ILCs consist of at least three phenotypically distinct subsets, including NK cells, CD127(+) ILC1, and intraepithelial CD103(+) ILC1. In inflamed intestinal tissues from Crohn's disease patients, numbers of CD127(+) ILC1 increased at the cost of ILC3. Here we found that differentiation of ILC3 to CD127(+) ILC1 is reversible in vitro and in vivo. CD127(+) ILC1 differentiated to ILC3 in the presence of interleukin-2 (IL-2), IL-23, and IL-1β dependent on the transcription factor RORγt, and this process was enhanced in the presence of retinoic acid. Furthermore, we observed in resection specimen from Crohn's disease patients a higher proportion of CD14(+) dendritic cells (DC), whi…

Internet of things: an exploratory study of the co-creation of value

2016

Internet Of Things (IoT) provides consumers a continuous access to real-time notifications and data. Using the « Service-Dominant Logic Theory » framework (Vargo and Lusch, 2004), this paper aims to compare brands value propositions and consumer perceptions regarding bracelets and smart watches. Data analysis is based on two sets of data collections: the first concerns the content of eight manufacturers websites; the second comes from a non-participant observation of consumer opinions about connected devices (netnography). Results show a typology of gains and pains, significant interactions between the different value components and consumers’ compensation phenomena. Furthermore, discrepanc…

2015

Aims To investigate the feasibility and to compare three devices measuring intraocular pressure (IOP) in mucopolysaccharidosis patients (MPS): iCare rebound tonometer (RT), Perkins applanation tonometer (PAT) and ocular response analyzer (ORA)

Sacred Music Production and Circulation in Sixteenth-Century Palermo: The Inventories of Giovanni Santoro (1550) and Luis Ruiz (1595)

2016

L'importanza degli inventari per lo studio della vita musicale a Palermo è stata riconosciuta soltanto di recente. Nonostante la natura frammentaria dei dati, questi documenti forniscono informazioni di rilievo sulle edizioni musicali, sugli strumenti, sulla cultura materiale che li produceva, nonché sulla circolazione della musica. Considerata la mancanza di testimoni musicali siciliani tra Cinque e Settecento, tale importanza appare ancor più evidente. Difatti, gli inventari palermitani testimoniano la presenza di libri di musica non più esistenti, in particolare musica a stampa, ma anche manoscritti e libri liturgici. L'articolo si sofferma su due inventari del Cinquecento. Il primo è l'…

A genome-wide transcriptional study reveals that iron deficiency inhibits the yeast TORC1 pathway

2019

Iron is an essential micronutrient that participates as a cofactor in a broad range of metabolic processes including mitochondrial respiration, DNA replication, protein translation and lipid biosynthesis. Adaptation to iron deficiency requires the global reorganization of cellular metabolism directed to optimize iron utilization. The budding yeast Saccharomyces cerevisiae has been widely used to characterize the responses of eukaryotic microorganisms to iron depletion. In this report, we used a genomic approach to investigate the contribution of transcription rates to the modulation of mRNA levels during adaptation of yeast cells to iron starvation. We reveal that a decrease in the activity…

The elemental role of iron in DNA synthesis and repair

2017

Iron is an essential redox element that functions as a cofactor in many metabolic pathways. Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase, use iron as an indispensable cofactor to function. Recent striking results have revealed that the catalytic subunit of DNA polymerases also contains conserved cysteine-rich motifs that bind iron–sulfur (Fe/S) clusters that are essential for the formation of stable and active complexes. In line with this, mitochondrial and cytoplasmic defects in Fe/S cluster biogenesis and insertion into the nuclear iron-requiring enzymes involved in DNA synthesis a…

Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency

2014

Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox-active cofactor in many biological processes, including DNA replication and repair. Eukaryotic ribonucleotide reductases (RNRs) are Fe-dependent enzymes that catalyze deoxyribonucleoside diphosphate (dNDP) synthesis. We show here that the levels of the Sml1 protein, a yeast RNR large-subunit inhibitor, specifically decrease in response to both nutritional and genetic Fe deficiencies in a Dun1-dependent but Mec1/Rad53- and Aft1-independent manner. The decline of Sml1 protein levels upon Fe starvation depends on Dun1 forkhead-associated and kinase domains, the 26S proteasome, and the vacuolar pr…