Search results for "SAC"
showing 10 items of 3337 documents
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
2006
Item does not contain fulltext BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype transactivation ability) had different prognostic and predictive values in CRC compared with mutations that retained significant activity. MATERIALS AND METHODS: TP53 mutations within a large, international database of CRC (n = 3583) were classified ac…
Quantifying Preferential Trading in the e-MID Interbank Market
2013
Interbank markets allow credit institutions to exchange capital for purposes of liquidity management. These markets are among the most liquid markets in the financial system. However, liquidity of interbank markets dropped during the 2007-2008 financial crisis, and such a lack of liquidity influenced the entire economic system. In this paper, we analyze transaction data from the e-MID market which is the only electronic interbank market in the Euro Area and US, over a period of eleven years (1999-2009). We adapt a method developed to detect statistically validated links in a network, in order to reveal preferential trading in a directed network. Preferential trading between banks is detecte…
¿Qué papel juegan la evitación del daño y la sensación de inacabado en los síntomas obsesivos de orden y comprobación?
2020
Numerosas investigaciones han intentado determinar las variables implicadas en la génesis y mantenimiento del Trastorno Obsesivo-Compulsivo (TOC). Recientemente, se han propuesto la evitación del daño y la sensación de inacabado como dos dimensiones nucleares motivadoras de la sintomatología obsesivo-compulsiva. El objetivo de este estudio fue analizar el papel de la evitación del daño y la sensación de inacabado en su relación con los síntomas obsesivo-compulsivos. Para ello, se realizó un Path analysis en una muestra de 267 personas de la población general (74,5% mujeres; edad media 27,29 años). Los resultados mostraron que la asociación entre evitación del daño y los síntomas de orden y …
Leadership Team Tool for better meaning making
2016
Purpose– The purpose of this paper is to present a Leadership Team Tool for developing reflexivity in the context of leadership teams.Design/methodology/approach– The Leadership Team Tool is based on the theoretical premises of seeing communication as meaning making, and therefore placing discourse and conversation in the center of developing leadership teams.Findings– The paper illustrates how reflexivity can be facilitated through a structured process of using the Leadership Team Tool. An empirical investigation of using the tool in an authentic leadership team setting is warranted to further develop the Leadership Team Tool.Originality/value– The paper makes a practical contribution to s…
Patterns of psychological contract and their relationships to employee well-being and in-role performance at work: longitudinal evidence from univers…
2016
AbstractThis study identified patterns of psychological contract (PC) and examined how these patterns were related to employee well-being and in-role performance over time (T1–T3). PC was measured at T1 based on cross-sectional data and well-being and performance longitudinally in two consecutive years (T1−T3) among university employees. Latent profile analysis revealed six different patterns of PC at T1. These were labelled (1) strong and balanced (n = 131), (2) average and balanced (n = 382), (3) employer-focused (n = 79), (4) employee-focused (n = 59), (5) balanced transactional (n = 224) and (6) employee-focused relational (n = 322). The longitudinal findings showed that the employees i…
How does the online service level influence consumers’ purchase intentions before a transaction? A formative approach
2016
AbstractThe present paper tries to study the impact of online services level in contexts where transactions have not been done yet, through the adoption of a formative approach. In this scene, the present research considers two main dimensions of online services (pre-purchase services and transaction-related services) in a context of clothing purchasing process. Before defining the research and determining the sector to be analyzed, 7 focus groups were conducted. From the obtained conclusions, this study was carried on in the textile sector. A survey with 370 effective respondents was carried out. To measure the different concepts in the model, several scales were used based on literature p…
Transformational leadership, learning, and employability
2011
PurposeNumerous empirical works have found evidence to support a positive relationship between managers' transformational leadership behaviour and employees' individual performance. Studies have also begun to examine the process by which the effects on performance ultimately take place. This research aims to move forward in this direction. The paper aims to analyse the mediating role of a contextual variable (organizational learning capability) and a subordinate characteristic (employability) in the relationship between transformational leadership and individual performance.Design/methodology/approachThe hypothesis was tested through a sample of 795 workers from 75 university departments, u…
The influence of leadership styles on the internationalisation of 'born-global' firms and traditionally global-expanding firms
2018
Leadership and internationalisation are both established areas of scientific research, yet their interplay remains insufficiently examined. The present study focuses on the former and aims to shed more light on the intersection of leadership and internationalisation. By utilising fsQCA, a qualitative comparative analysis, to a set of 437 active international firms, results suggest that under distinct conditions transactional as well as transformational leadership can lead to a high level of internationalisation for both traditional internationalising and so-called 'born-global' firms.
Culture specific and cross-culturally generalizable implicit leadership theories
1999
This study focuses on culturally endorsed implicit theories of leadership (CLTs). Although cross-cultural research emphasizes that different cultural groups likely have different conceptions of what leadership should entail, a controversial position is argued here: namely that attributes associated with charismatic/transformational leadership will be universally endorsed as contributing to outstanding leadership. This hypothesis was tested in 62 cultures as part of the Global Leadership and Organizational Behavior Effectiveness (GLOBE) Research Program. Universally endorsed leader attributes, as well as attributes that are universally seen as impediments to outstanding leadership and cultur…
Charismatic leadership: a key factor in organizational communication
1997
Based on Plato's thinking, connects several aspects of communication and leadership theory to focus on charismatic leadership. Speculates on the application of Plato's ideas to managerial communication and makes recommendations.