Search results for "SAPK"

showing 7 items of 7 documents

Translating Polish Fantasy – translational challenges and problems concerning culture‑rooted elements

2015

Tłumacząc polską fantasy – wyzwania i problemy tłumaczeniowe związane z elementami kulturowymi
 Niniejszy artykuł porusza kwestię trudności i problemów, które może napotkać tłumacz podczas przekładu polskich powieści z gatunku fantasy na język angielski. Zwrócono szczególną uwagę na charakterystykę i specyfikę gatunku oraz jego historię w polskiej tradycji literackiej. Druga część artykułu została poświęcona możliwym wyzwaniom towarzyszącym przekładowi gatunku fantasy zaprezentowanym przez Guttfeld [2008] oraz związanym z tłumaczeniem elementów nacechowanych kulturowo omówionym przez Hejwowskiego [2004]. W trzeciej części podano wybrane przykłady elementów kulturowych i ich tłumaczeń z…

Cultural StudiesLinguistics and LanguagePsychoanalysisTranslating and interpretingLiterature and Literary Theoryfantasytranslationculture‑bound itemsLanguage and LinguisticsSapkowskiP306-310FantasyTheologyPsychologyMiędzy Oryginałem a Przekładem
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Mācību vides organizācija organizācija bērnu pašapkalpošanās prasmju veidošanai 1,5 – 3 gadu veciem bērniem

2020

Kvalifikācijas darba tēma: Mācību vides organizācija bērnu pašapkalpošanās prasmju veidošanai 1,5 – 3 gadu veciem bērniem. Pētījuma mērķis: pētīt, kā organizēt mācību vidi pirmsskolā pašapkalpošanās prasmju sekmēšanai 1,5-3 gadus veciem bērniem. Kvalifikācijas darba apjoms: 55 lapas un tajā ir 7 attēli, 7 tabulas, izmantoti 40 literatūras avoti, pievienoti 4 pielikumi. Darbs sastāv no trim nodaļām - pirmajā un otrajā nodaļā tika analizēta literatūra par pašapkalpošanās prasmju attīstību, metodem un mācību vidi organizēšanu. Trešajā nodaļā ir veikta pedagoģiska novērošana par pašapkalpošanas prasmju attīstību 1,5 – 3 gadus veciem bērniem un raksturots pedagoģiskais process, kas vērsts uz paš…

Pedagoģijamācību videpirmsskolas izglītībajaunākais pirmsskolas vecumspasapkalpošanas prasmespātstāvība
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Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 M…

2003

Abstract Oxidative stress induced by a glucose/glucose oxidase (G/GO) generator system dose-dependently decreased the viability of cultured vascular smooth muscle cells (VSMC) as estimated by MTT assay. Cell death was induced in 40% of cells exposed to 0.2 IU/ml of the free radical generating mixture. Annexin-V labeling, Hoechst staining together with DNA laddering demonstrated that apoptosis was responsible for this cell loss. Pretreatment of the cells with 10−8 M calcitonin gene-related peptide (CGRP) significantly attenuated the damaging effect of the oxidative stress. Indeed, cell viability was estimated to be 80% in CGRP-treated group, instead of 60% in absence of CGRP treatment. This …

Programmed cell deathVascular smooth musclep38 mitogen-activated protein kinasesCalcitonin Gene-Related PeptideMyocytes Smooth MuscleApoptosisBiologyDNA ladderingCalcitonin gene-related peptidemedicine.disease_causeProtective AgentsMuscle Smooth VascularmedicineAnimalsHumansCGRPViability assayRats WistarMolecular BiologyCells CulturedMitogen-Activated Protein Kinase 3integumentary systemSAPKCell BiologyHydrogen PeroxideMAPKMolecular biologyRatsUp-RegulationNeuropeptideOxidative StressMitogen-activated protein kinaseVascular smooth muscle cellbiology.proteinMitogen-Activated Protein KinasesOxidative stressReceptors Calcitonin Gene-Related PeptideSignal TransductionBiochimica et biophysica acta
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Decreased SAPK/JNK signalling affects cytokine release and STAT3 activation in psoriatic fibroblasts.

2015

STAT3 Transcription FactorMAP Kinase Signaling Systemmedicine.medical_treatmentDermatologyBiochemistryp38 Mitogen-Activated Protein KinasesPsoriasismedicineSapk jnkHumansPsoriasisPhosphorylationSTAT3Molecular BiologyStat3 activationMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3biologyChemistryInterleukin-6Tumor Necrosis Factor-alphaInterleukin-8JNK Mitogen-Activated Protein KinasesTranscription Factor RelAFibroblastsmedicine.diseaseSignallingCytokineCase-Control StudiesCancer researchbiology.proteinPhosphorylationTumor necrosis factor alphaExperimental dermatology
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Andrzej Sapkowski: Narrenturm 2

2019

Kirja-arvostelu teoksesta Adrzej Sapkowski. Narrenturm 2. WSOY 2019. 347 sivua. nonPeerReviewed

Sapkowski Andrzejkirja-arvostelutNarrenturm 2
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Nokkelaa sanailua ja reteää seikkailua infodumppauspedillä

2019

Arvostelu teoksesta Andrzej Sapkowski. Narrenturm 1: WSOY 2018. 396 sivua. nonPeerReviewed

kirja-arvostelutSapkowski AndrzejNarrenturm 1fantasiakirjallisuus
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Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

2011

Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cisplatin-DNA adducts at late times (16–24 h) after drug treatment in both human and mouse cells. Transfection of platinated plasmid DNA also caused SAPK/JNK activation. A defect in transcription-coupled nucleotide excision repair resting on a mutation in Cockayne syndrome group B protein promoted the late SAPK/JNK activation following cisplatin exposure. Signaling to SAPK/JNK was accompanied by act…

rho GTP-Binding ProteinsDNA RepairMAP Kinase Kinase 4DNA repairDNA damageDNA damage response; DNA repair; cisplatin-DNA adducts; SAPK/JNKp38 mitogen-activated protein kinasesAntineoplastic AgentsCell Cycle ProteinsAtaxia Telangiectasia Mutated ProteinsProtein Serine-Threonine KinasesDNA and ChromosomesBiologyBiochemistryAtaxia Telangiectasia Mutated ProteinsDNA AdductsMiceRadiation IonizingAnimalsHumansDNA Breaks Double-StrandedMolecular BiologyReplication protein ACells CulturedMice KnockoutKinaseTumor Suppressor ProteinsJNK Mitogen-Activated Protein KinasesCell BiologyMolecular biologyDNA-Binding ProteinsEnzyme Activationc-Jun N-terminal kinasesbiology.proteinCisplatinSignal TransductionNucleotide excision repairJournal of Biological Chemistry
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