Search results for "SEGR"
showing 10 items of 184 documents
CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly
2016
SummaryHuman centromeres are defined by chromatin containing the histone H3 variant CENP-A assembled onto repetitive alphoid DNA sequences. By inducing rapid, complete degradation of endogenous CENP-A, we now demonstrate that once the first steps of centromere assembly have been completed in G1/S, continued CENP-A binding is not required for maintaining kinetochore attachment to centromeres or for centromere function in the next mitosis. Degradation of CENP-A prior to kinetochore assembly is found to block deposition of CENP-C and CENP-N, but not CENP-T, thereby producing defective kinetochores and failure of chromosome segregation. Without the continuing presence of CENP-A, CENP-B binding …
Convergent Evolution in Intracellular Elements: Plasmids as Model Endosymbionts
2018
Endosymbionts are organisms that live inside the cells of other species. This lifestyle is ubiquitous across the tree of life and is featured by unicellular eukaryotes, prokaryotes, and by extrachromosomal genetic elements such as plasmids. Given that all of these elements dwell in the cytoplasm of their host cell, they should be subject to similar selection pressures. Here we show that strikingly similar features have evolved in both bacterial endosymbionts and plasmids. Since host and endosymbiont are often metabolically tightly intertwined, they are difficult to disentangle experimentally. We propose that using plasmids as tractable model systems can help to solve this problem, thus allo…
Una segregazione paradossale e multi-scalare: il caso del quartiere ZEN di Palermo
2016
L’articolo affronta la questione della segregazione nel quartiere ZEN di Palermo (Sicilia). L’impianto teorico dialoga con la letteratura anglosassone, ma ne prende le distanze nel tentativo di individuare alcune specificità locali del caso. L’obiettivo è duplice: intanto indentificare alcuni “movimenti geostorici” che hanno caratterizzato il quartiere, collegando a ciascuno di questi una fase del processo segregativo; inoltre, rappresentare la segregazione del quartiere in forma cartografica, mediante l’uso di alcuni ideogrammi e mappe mentali. This article deals with the issue of segregation in the ZEN district of Palermo, Sicily. The theoretical framework is built around Anglo-Saxon refe…
Moduli spaces of rank two aCM bundles on the Segre product of three projective lines
2016
Let P^n be the projective space of dimension n on an algebraically closed field of characteristic 0 and F be the image of the Segre embedding of P^1xP^1xP^1 inside P^7. In the present paper we deal with the moduli spaces of locally free sheaves E on F of rank 2 with h^i(F,E(t))=0 for i=1,2 and each integer t.
Synergy of spatial frequency and orientation bandwidth in texture segregation
2021
Defining target textures by increased bandwidths in spatial frequency and orientation, we observed strong cue combination effects in a combined texture figure detection and discrimination task. Performance for double-cue targets was better than predicted by independent processing of either cue and even better than predicted from linear cue integration. Application of a texture-processing model revealed that the oversummative cue combination effect is captured by calculating a low-level summary statistic (\(\Delta CE_m\)), which describes the differential contrast energy to target and reference textures, from multiple scales and orientations, and integrating this statistic across channels wi…
Rasisms un noziegumi Voltera Moslija detektīvromānos "Velns zilā kleitā", "Sarkanā nāve" un "Balts tauriņš"
2019
Bakalauradarbs „Rasisms un kriminālsVolteraMoslijadetektīvromānos „Velnszilākleitā”, „Sarkanānāve” un „Baltstauriņš”” analizēnosauktus romānus ar uzsvaru uz aprakstītas kriminālas situācijas un rasismu ASV kopumā un Kalifornijā. Ņemot vērā ka romāni pieder pie daiļliteratūras un autora situācijas redzējums var atšķirties no reālas situācijas ASV četrdesmitajos un piecdesmitajos gados, ir savākta un apkopota informācija par rasisma un segregācijas vēsturi ASV, lai izprastu, cik patiess priekšstats par situāciju autors dod. Bakalaura darba mērķis ir atrast rasisma un segregācijas piemērus romānos; saprast, kā atrastie piemēri ilustrē rasisma, augstu ieslodzīto un apsūdzēto afroamerikāņu īpats…
Rank two aCM bundles on the del Pezzo fourfold of degree 6 and its general hyperplane section
2018
International audience; In the present paper we completely classify locally free sheaves of rank 2 with vanishing intermediate cohomology modules on the image of the Segre embedding $\mathbb{P}^2$ x $\mathbb{P}^2 \subseteq \mathbb{P}^8$ and its general hyperplane sections.Such a classification extends similar already known results regarding del Pezzo varieties with Picard numbers 1 and 3 and dimension at least 3.
El proyecto mapa escolar de Valencia: Análisis de la zonificación educativa de la ciudad de Valencia
2018
The research project Mapa Escolar de Valencia (School Map of Valencia) was born out of an agreement between the City Council and the University of Valencia in order to carry out an investigation of the compulsory education system of the city and propose, if necessary, modifications to the current school zoning. The project is structured in several research areas. An analysis of the specialized scientific literature and public policies concerning education and schooling has been done, and it is currently analysing the evolution of quantitative and qualitative data on compulsory schooling in Valencia, its school zoning, the representations of education and the school climate in the city schoo…
El concepto icónico de san Francisco de Borja elaborado por los jesuitas a partir de la adquisición del palacio ducal de Gandía
2012
Català: Estudi de la iconografia de sant Francesc de Borja al Palau ducal de Gandia arran de l’adquisició de l’edifici per part dels jesuïtes el 1890, centrat en els programes visuals desenvolupats a les pintures de Martín Coronas –recuperació de l’etapa ducal del personatge– i Josep Segrelles –devoció eucarística. Paraules clau: Francesc de Borja; Iconografia; Josep Segrelles; Martín Coronas; Palau ducal de Gandia. Castellano: Estudio de la iconografía de san Francisco de Borja en el Palacio ducal de Gandía después de que los jesuitas lo adquiriesen en 1890, dedicado a los programas visuales desarrollados en las pinturas de Martín Coronas –recuperación de la etapa ducal del personaje– y Jo…
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
2006
AbstractBackgroundIncorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome segregation fidelity and preventing aneuploidy. Alteration of p53 and pRb functions by expression of HPV16-E6 and E7 oncoproteins has been associated with centrosome amplification. However, these last findings could be the result of targeting cellular proteins in addition to pRb by HPV16-E7 oncoprotein. To get a more detailed picture on the role of pRb in chromosomal instability and centrosome amplification, we analyzed the effects of the acute loss …