Search results for "SEP"

Isolation and molecular characterization of brain microvascular endothelial cells from human brain tumors.

2002

Brain tumor formation and growth is accompanied by the proliferation and infiltration of blood capillaries. The phenotypes of endothelial cells that make up capillaries are known to differ not only in the tissues in which endothelial cells are located but also as a result of the microenvironment to which they are exposed. For this reason, primary cultures of brain endothelial cells were isolated from human brain tumors removed by surgery and compared with cells from normal tissue. The primary confluent monolayers that grew out of isolated capillary fragments consisted of closely associated, elongated, fusiform-shaped cells. But brain tumor-derived endothelial cells in culture exhibited sign…

In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells

2006

Many stem cell types have been shown to differentiate into endothelial cells (ECs); however, their specification to arterial or venous endothelium remains unexplored. We tested whether a specific arterial or venous EC fate could be induced in human multipotent adult progenitor cells (hMAPCs) and AC133(+) cells (hAC133(+)). In vitro, in the presence of VEGF(165), hAC133(+) cells only adopted a venous and microvascular EC phenotype, while hMAPCs differentiated into both arterial and venous ECs, possibly because hMAPCs expressed significantly more sonic hedgehog (Shh) and its receptors as well as Notch 1 and 3 receptors and some of their ligands. Accordingly, blocking either of those pathways …

Vasopressor-Sparing Strategies in Patients with Shock: A Scoping-Review and an Evidence-Based Strategy Proposition

2021

Despite the abundant literature on vasopressor therapy, few studies have focused on vasopressor-sparing strategies in patients with shock. We performed a scoping-review of the published studies evaluating vasopressor-sparing strategies by analyzing the results from randomized controlled trials conducted in patients with shock, with a focus on vasopressor doses and/or duration reduction. We analyzed 143 studies, mainly performed in septic shock. Our analysis demonstrated that several pharmacological and non-pharmacological strategies are associated with a decrease in the duration of vasopressor therapy. These strategies are as follows: implementing a weaning strategy, vasopressin use, system…

“Donavas septītnieka” notikuma motivācija un konsekvences sieviešu ordinācijas jautājuma aktualizēšanā Romas katoļu baznīcā

2019

Bakalaura darbs “Donavas septītnieka notikuma motivācija un konsekvences sieviešu ordinācijas jautājuma aktualizēšanā Romas katoļu baznīcā” pievērš uzmanību aktuālam jautājuma par sieviešu ordinācijas iespējamību Romas katoļu baznīcā. Temats ir aktuāls, jo, lai arī Vatikāns vienmēr ir norādījis, ka sieviešu ordinācija nav pieejama, norādot, ka starp Jēzus izvēlētajiem apustuļiem bija tikai vīrieši, dažādas opozicionāru kustības Romas katoļu baznīcā īpaši pēc Vatikāna II koncila, cīnās par sieviešu vienlīdzīgām tiesībām baznīcā. Pētījumā noskaidrots, ka “Donavas septītnieka” notikuma motivācija balstās, pirmkārt, idejā, ka arī sievietēm var būt dievišķs aicinājums uz ordinētu priesterību, ot…

Spatio-temporal Vegetation Recuperation after a Grassland Fire in Lithuania

2013

The aim of this work is to study the spatio-temporal effects of a grassland fire in Lithuania. Immediately after the fire, a experimental plot was designed in a east-faced slope. Vegetation cover and height were measured 10, 17, 31 and 46 days after the fire (vegetation cover was only measured until 31 days after the fire because in the last measurement campaign the plot was completely covered). The results showed that vegetation recovered very fast. Ten days after the fire vegetation cover and height distribution were heterogeneous, decreasing with the time due to vegetation spread. Vegetation recovered was specially observed between 17 and 31 days after the fire due vegetation recuperatio…

La chiesa dell'Ospedale di San Lazzaro dei Mendicanti

1991

Zvaigžņotā Debess: 2014/15, Ziema (226)

2014

Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: J.Stradiņš. Vestige of Otto Schmidt in Latvia (abridged) ; Leonora Roze. All-Union Conference in Latvian State University (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. Gravitational Waves and Cosmic Inflation ; DISCOVERIES: A.Alksnis. Light Echoes from Supernova 2014J in Galaxy M82 ; A.Alksnis. Discovery of the Benešov Meteorites 20 Years after the Bolide Event ; I.Pundure. Giant Filament on the Sun Watched by NASA's SDO ; I.Pundure. MAVEN’s Mars Exploration Mission Started ; SPACE RESEARCH and EXPLORATION: R.Misa. Plasma Engines and Ad Astra Rocket Company ; LATVIAN SCIENTISTS: J.Freimanis. Reviewing My 60 Years of Life (concluded) ; KĀRLI…

July 2003: 62-year-old female with progressive muscular weakness

2004

The July 2003 Case of the Month (COM). A 62-year-old female patient experienced progressive muscular weakness over the last ten years, involving shoulder and pelvic girdle muscles, paraspinal and facial muscles. A biopsy was taken from the left deltoid muscle where hepatitis vaccination had taken place 4 weeks previously. The specimen revealed macrophagic myofasciitis due to the injection of aluminium-bound vaccines. The finding can be reproduced experimentally by injecting vaccines in rats. The pathomechanism is supposed to involve immune stimulation due to long term persistence of the adjuvant. Macrophagic myofasciitis has been suggested to occasionally cause myopathy but is supposed to b…

α-Tocopherol Modulates Phosphatidylserine Externalization in Erythrocytes

2006

Objective— The aim of the present study was to assess the effect of α-tocopherol, the main vitamin E isomer on phosphatidylserine (PS) exposure at the surface of circulating erythrocytes, and to determine consequences on erythrocyte properties. Methods and Results— In vitro α-tocopherol enrichment of isolated erythrocytes significantly decreased PS externalization as assessed by lower Annexin V-fluorescein isothiocyanate labeling. Plasma phospholipid transfer protein (PLTP) transfers vitamin E, and both α-and γ-tocopherol accumulated in circulating erythrocytes from PLTP-deficient homozygous (PLTP −/− ) mice as compared with wild-type mice. In agreement with in vitro studies, vitamin E–enr…

Bach fra le stelle

2014

Il testo costituisce la postfazione del volume di Ramin Bahrami "Il suono dell'Occidente. Le opere musicali che hanno fatto la nostra civiltà" (Mondadori 2014) e prende le mosse dal concetto di "Enciclopedia" per tracciare una riflessione storico-musicologica sulle 14 composizioni che Ramin Bahrami ssume quali imprescindibili punti di riferimento per una visione d'insieme della cultura musicale occidentale: da Monteverdi fino a Schoenberg, passando per Vivaldi, Bach, Wagner, Verdi, Mahler, Rakhmaninov e Stravnsky.