Search results for "SETS"

Aminobisphosphonate-activated γδ T cells in immunotherapy of cancer: doubts no more

2008

BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill most tumour cells because of recognition by T cell receptor and natural killer receptors. OBJECTIVE: We discuss the possibility that the intentional activation of gammadelta T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in cancer patients. METHODS: The antitumoral effects of gammadelta T cells both in vitro and in vivo have been demonstrated suggesting a new therapeutic approach for translation into the clinical setting. RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent a particularly interesting target for immunotherapeutic …

Microsporidia and Its Relation to Crohn's Disease. A Retrospective Study

2013

Background: The cause of Crohn's Disease (CD) remains unknown. Recently a decrease in the global lymphocyte population in the peripheral blood of CD patients has been reported. This decrease was more evident in gamma delta T lymphocytes, especially gamma delta CD8+T subsets. Furthermore, a decrease of IL-7 was also observed in these patients. We propose the hypothesis that microsporidia, an obligate intracellular opportunistic parasite recently related to fungi, in CD patients can take advantage of the lymphocytes and IL-7 deficits to proliferate and to contribute to the pathophysiology of this disease. Methods and Findings: In this case-control study, serum samples were collected from 36 C…

Mechanism in allergic contact dermatitis.

1993

Stimulator cell-dependent requirement for CD2- and LFA-1-mediated adhesions in T lymphocyte activation by superantigenic toxins.

1992

Abstract The staphylococcal enterotoxins and related microbial T cell mitogens stimulate T cells by cross-linking variable parts of the T cell receptor (TCR) with MHC class II molecules on accessory or target cells. We have used cloned human T cells and defined tumor cells as accessory cells (AC) to study the requirements for T cell activation by these toxins. On AC expressing high levels of CD54 (intercellular adhesion molecule-1, ICAM-1) and CD58 (lymphocyte function-associated antigen-3, LFA-3), mAb to CD2 were relatively ineffective in inhibiting the response to the toxins and antibodies to the lymphocyte function-associated antigen-1 (LFA-1) did not inhibit at all. If added together, h…

2020

Abstract This paper shows global uniqueness in two inverse problems for a fractional conductivity equation: an unknown conductivity in a bounded domain is uniquely determined by measurements of solutions taken in arbitrary open, possibly disjoint subsets of the exterior. Both the cases of infinitely many measurements and a single measurement are addressed. The results are based on a reduction from the fractional conductivity equation to the fractional Schrodinger equation, and as such represent extensions of previous works. Moreover, a simple application is shown in which the fractional conductivity equation is put into relation with a long jump random walk with weights.

Mappings of finite distortion : size of the branch set

2018

Abstract We study the branch set of a mapping between subsets of ℝ n {\mathbb{R}^{n}} , i.e., the set where a given mapping is not defining a local homeomorphism. We construct several sharp examples showing that the branch set or its image can have positive measure.

On the stability of the Serrin problem

2008

We investigate stability issues concerning the radial symmetry of solutions to Serrin's overdetermined problems. In particular, we show that, if $u$ is a solution to $\Delta u=n$ in a smooth domain $\Omega \subset \rn$, $u=0$ on $\partial\Omega$ and $|Du|$ is close to 1 on $\partial\Omega$, then $\Omega$ is close to the union of a certain number of disjoint unitary balls.

The Calderón problem for the fractional Schrödinger equation

2020

We show global uniqueness in an inverse problem for the fractional Schr\"odinger equation: an unknown potential in a bounded domain is uniquely determined by exterior measurements of solutions. We also show global uniqueness in the partial data problem where the measurements are taken in arbitrary open, possibly disjoint, subsets of the exterior. The results apply in any dimension $\geq 2$ and are based on a strong approximation property of the fractional equation that extends earlier work. This special feature of the nonlocal equation renders the analysis of related inverse problems radically different from the traditional Calder\'on problem.

Architettura per il terzo fragile. I patrimoni di Pizzo Sella fra riuso sociale, sostenibilità civica e giustizia spaziale

2022

Il territorio palermitano è il primo in Europa per presenza di beni confiscati. I casi sono diverse migliaia e compongono una realtà emblematica rispetto ai fattori di fragilità sociali e spaziali dei ter-ritori contesi fra crimine e giustizia, in cui spicca la vicenda iconica e irrisolta di Pizzo Sella. La ricerca di cui quest’articolo restituisce alcuni risultati indaga quindi il rapporto fra la produzio-ne dell’architettura della res publica e i contesti in cui il concetto di Pubblico è in panne, in cui la diversione dalla legge e l’antagonismo esercitato da forze illegali non sono un’aberrazione tempora-nea, ma la regola, e lasciano tracce materiali sui modi di produzione delle forme co…

A very brief history of soft computing: Fuzzy Sets, artificial Neural Networks and Evolutionary Computation

2013

This paper gives a brief presentation of history of Soft Computing considered as a mix of three scientific disciplines that arose in the mid of the 20th century: Fuzzy Sets and Systems, Neural Networks, and Evolutionary Computation. The paper shows the genesis and the historical development of the three disciplines and also their meeting in a coalition in the 1990s.