Search results for "SHAP"
showing 10 items of 745 documents
Neutrophil‐mediated enhancement of angiogenesis and osteogenesis in a novel triple cell co‐culture model with endothelial cells and osteoblasts
2017
Repair and regeneration of critical‐sized bone defects remain a major challenge in orthopaedic and craniomaxillofacial surgery. Until now, attempts to bioengineer bone tissue have been hindered by the inability to establish proper angiogenesis and osteogenesis in the tissue construct. In the present study, we established a novel triple cell co‐culture model consisting of osteoblasts, endothelial cells, and neutrophils and conducted a systematic investigation of the effects of neutrophils on angiogenesis and osteogenesis. Neutrophils significantly increased angiogenesis in the tissue construct, evidenced by the formation of microvessel‐like structures with an extensive lattice‐like, stable t…
Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study
2015
Background Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few studies have directly compared callosal areas in psychotic versus nonpsychotic patients with this disorder. We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls. Methods We analyzed anatomic T-1 MRI data of patients with BD-I and healthy controls recruited from 4 sites (France, Germany, Ireland and the United States). We obtained the mid-sagittal areas of 7 CC subregions using an automatic CC delineation. Differences in regional callosal areas between patients and contr…
Modeling Human Endometrial Decidualization from the Interaction between Proteome and Secretome
2011
Context: Decidualization of the human endometrium, which involves morphological and biochemical modifications of the endometrial stromal cells (ESCs), is a prerequisite for adequate trophoblast invasion and placenta formation. Objective: This study aims to investigate the proteome and secretome of in vitro decidualized ESCs. These data were combined with published genomic information and integrated to model the human decidualization interactome. Design: Prospective experimental case–control study. Setting: A private research foundation. Patients: Sixteen healthy volunteer ovum donors. Intervention: Endometrial samples were obtained, and ESCs were isolated and decidualized in vitro. Main Ou…
Induction of Mitochondrial Changes Associated with Oxidative Stress on Very Long Chain Fatty Acids (C22:0, C24:0, or C26:0)-Treated Human Neuronal Ce…
2012
In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomalβ-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of VLCFAs at the mitochondrial level since mitochondrial dysfunctions play crucial roles in neurodegeneration. On human neuronal SK-NB-E cells treated with C22:0, C24:0, or C26:0 (0.1–20 μM; 48 h), an inhibition of cell growth and mitochondrial dysfunctions were observed by cell counting with trypan blue, MTT assay, and measurement of mitochondrial transmembrane potential (Δψm) with…
Caractérisation quantitative de la pulvérisation de pesticides par imagerie
2015
In recent years, advances in plant protection have contributed considerably to increasing crop yields in a sustainable way. Easy to apply and rather inexpensive, pesticides have proven to be very efficient. However, when pesticides are applied to crops some of the spray may not reach the target, but move outside the intended spray area. This can cause serious economic and environmental problems. Most of the pesticides are applied using agricultural sprayers. These sprayers use hydraulic nozzles which break the liquid into droplets with a wide range of droplet sizes and velocities and determine the spray pattern. Small droplets are prone to wind drift, while large droplets can runoff from th…
Sacelli "dimenticati" nell’area urbana di Akragas
2016
International audience; Between 1927 and 1930, Pirro Marconi investigated a small rectangular structure near house Filippazzo, in the central urban area of Akragas. The presence of a bothros and fragments of female figures with stephane suggested the presence of a small sanctuary or themenos for chthonic deities. The little news published by Marconi and the vague indication of location made us forget the existence of this sanctuary for many years. However, a survey carried out in 2016 allowed to identify the remains of Marconi’s structure, partly covered by ground. At the same time, other little-known structures have been identified. In some cases, their function is still unknown.
On the effectiveness of spif process to re-form end-of-life components as compared to conventional forming approach
2021
Manufacturing processes have a significant impact on global energy consumptions. The recovery of materials and functions for the implementation of the Circular Economy principle needs to be focused on either, by utilizing new techniques or the rethinking of old processes to rework End-of-Life (EoL) components. Previous researches have shown Single Point Incremental Forming (SPIF) process as a good alternative for sheet metal EoL components reuse by their reshaping. In this article, the authors aim to study the effectiveness of the SPIF processes by comparing its reshaping performance with other, more conventional forming processes. An initial Deep Drawing (DD) process was performed to imita…
ASE narrow‐band noise pulsing in erbium‐doped fiber amplifier and its effect on self‐phase modulation
2019
In this paper, we report a study of the features of polarized and unpolarized narrow-band amplified spontaneous emission (ASE) in a low-doped erbium fiber at 976-nm pumping. We demonstrate that ASE noise can be treated as a train of Gaussian-like pulses with random magnitudes, widths, and inter-pulse intervals. ASE noise can also provide a statistical analysis of these three parameters. We also present the data that reveal ASE noise’s role in optical spectrum broadening through self-phase modulation of light propagating in a communication fiber. In particular, the data show that the ASE noise derivative defines the broadening’s spectral shape.
Beneficial impact of wave-breaking for coherent continuum formation in normally dispersive nonlinear fibers
2008
International audience; We study the evolution of a pulse propagating in a normally dispersive fiber in the presence of Kerr nonlinearity. We review the temporal and spectral impact of optical wave-breaking in the development of a continuum. The impact of linear losses or gain is also investigated.
Electromagnetic Sensitivity Analysis and Shape Optimization Using Method of Moments and Automatic Differentiation
2009
Sensitivity analysis is an important part of gradient-based optimization of electromagnetic devices. We demonstrate how sensitivity analysis can be incorporated into an existing in-house method of moments solver with a relatively small amount of labor by using a technique called automatic differentiation (AD). This approach enables us to obtain (geometrical) sensitivities of the discrete solution with accuracy up to numerical precision. We compare the assembly time and memory usage of the modified and original solvers. Moreover, we optimize the shape of a dipole antenna and the dimensions of a Yagi-Uda array using the presented AD technique, traditional response level finite difference sens…