Search results for "SIGNAL"
showing 10 items of 6924 documents
Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor
2002
Ciliary neurotrophic factor (CNTF) displays neurotrophic activities on motor neurons and neural cell populations both in vivo and in vitro. On target cells lacking intrinsic expression of specific receptor alpha subunits cytokines of the IL-6 family only act in the presence of their specific agonistic soluble receptors. Here, we report the construction and expression of a CNTF/soluble CNTF-receptor (sCNTF-R) fusion protein (Hyper-CNTF) with enhanced biological activity on cells expressing gp130 and leukemia inhibitory factor receptor (LIF-R), but not membrane-bound CNTF-R. At the cDNA level, the C-terminus of the extracellular domain of human CNTF-R (amino acids 1-346) was linked via a sing…
Hyperfine interaction in the Autler-Townes effect: The formation of bright, dark, and chameleon states
2017
This paper is devoted to clarifying the implications of hyperfine (HF) interaction in the formation of adiabatic (i.e., ``laser-dressed'') states and their expression in the Autler-Townes (AT) spectra. We first use the Morris-Shore model [J. R. Morris and B. W. Shore, Phys. Rev. A 27, 906 (1983)] to illustrate how bright and dark states are formed in a simple reference system where closely spaced energy levels are coupled to a single state with a strong laser field with the respective Rabi frequency ${\mathrm{\ensuremath{\Omega}}}_{S}$. We then expand the simulations to realistic hyperfine level systems in Na atoms for a more general case when non-negligible HF interaction can be treated as…
Tuning four-wave mixing through temperature in ethanol-filled photonic crystal fiber
2016
In this paper, continuous tuning of four-wave mixing bands in an ethanol-filled photonic crystal fiber is investigated. A wide tuning range of the parametric bands, from 745 nm to 920 nm (signal) and from 1260 nm to 1710 nm (idler), is achieved through the thermo-optic effect. This corresponds to a frequency tuning range higher than 2000 cm−1; such wide range can be particularly useful in applications that require broadband wavelength conversion, e.g., CARS microscopy. Numerical calculations are in good agreement with experimental measurements.
Ridge-line optimal detector
2000
Image processing techniques have seen many developments in recent years. Starting from the pioneering work of Canny, Deriche developed a second order recursive filter capable of detecting stepped contours. However, there are other contour shapes that those filters struggle to detect. We describe a new optimal filter sensu Canny for detecting ridge-line contours. This is a third order recursive and even filter. It is dependent on three parameters by which detection accuracy is adjusted. The results obtained by applying this filter to (possibly noise- affected) images are compared with those in the work by Ziou. © 2000 Society of Photo-Optical Instrumentation Engineers. (S0091-3286(00)00706-6)
Characterisation of a symmetric AGATA detector using the imaging scanning technique
2013
Abstract The imaging scanning technique for the characterisation of large volume, highly segmented, HPGe detectors is demonstrated by comparing the measured spatial response of a symmetric AGATA crystal versus the theoretical calculations obtained with the Multi-Geometry Simulation (MGS) code. The signal rise-times measured as a function of the gamma-ray interaction positions, in both coaxial and planar regions of the detection volume, are presented and confronted with the expected behaviour obtained via MGS. The transition in charge carrier transport behaviour as a function of the depth is studied for the region of the complex electric field. In general, a fairly good agreement between the…
Generalized feed-forward based method for wind energy prediction
2013
Abstract Even though a number of new mathematical functions have been proposed for modeling wind speed probability density distributions, still the Weibull function continues to be the most commonly used model in the literature. Therefore, the parameters of this function are still widely used to obtain typical wind probability density distributions for finding the wind energy potential by researchers, engineers and designers. Once long-term average of Weibull function’s parameters are known, then the probability density distributions can easily be obtained. Artificial neural network (ANN) can be used as alternative to analytical approach as ANN offers advantages such as no required knowledg…
Determination of the LEP centre-of-mass energy from Zγ events
1999
Radiative returns to the Z resonance (Zgamma events) are used to determine the LEP2 centre-of-mass energy from the data collected with the ALEPH detector in 1997. The average centre-of-mass energy is measured to be: E_CM = 182.50 +- 0.19(stat) +- 0.08(syst) GeV in good agreement with the precise determination by the LEP energy working group of 182.652 +- 0.050 GeV. If applied to the measurement of the W mass, its precision translates into a systematic error on M_W which is smaller than the statistical error achieved from the corresponding dataset.
40-GHz photonic waveform generator by linear shaping of four spectral sidebands
2015
International audience; We show that the amplitude and phase shaping of only four sidebands of the optical spectrum is sufficient to synthesize parabolic, triangular, or flat-top pulse trains at high repetition rates. Selection of the symmetric carrier-suppressed waveform is easily achieved by changing the phase difference between the inner and outer spectral lines. Experiments carried out at a repetition rate of 40 GHz confirm the high quality of the intensity profiles that are obtained.
The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma
2014
Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma. No information is available on the relations between the IL-31/IL-31R complex and B-cell lymphoma. Here we have addressed this issue in follicular lymphoma (FL), a prototypic germinal center(GC)-derived B-cell malignancy. IL-31 enhanced primary FL cell proliferation through IL-31R-driven signal transducer and activator of transcription factor 1/3 (STAT1/3), extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation. In contrast, GC B cells d…
Spatial noise-aware temperature retrieval from infrared sounder data
2020
In this paper we present a combined strategy for the retrieval of atmospheric profiles from infrared sounders. The approach considers the spatial information and a noise-dependent dimensionality reduction approach. The extracted features are fed into a canonical linear regression. We compare Principal Component Analysis (PCA) and Minimum Noise Fraction (MNF) for dimensionality reduction, and study the compactness and information content of the extracted features. Assessment of the results is done on a big dataset covering many spatial and temporal situations. PCA is widely used for these purposes but our analysis shows that one can gain significant improvements of the error rates when using…