Search results for "SIM"
showing 10 items of 10139 documents
A two-phase insertion technique of unexpected customers for a dynamic dial-a-ride problem
2006
Abstract This work deals with a dynamic dial-a-ride problem with time window constraints. In particular, new unplanned requests for service may arise at a vehicle stop and the driver must decide in real-time whether to accept or reject them. For this problem, we have developed a two-phase insertion algorithm based on route perturbations: the first phase, which is run off-line when the vehicle moves between two successive stops, aims at creating a feasible neighborhood of the current route; while the second phase, which is run in real-time every time a new request occurs, inserts, when possible, the delivery stop of the new customer in the current route.
Minimizing fleet operating costs for a container transportation company
2006
Abstract This paper focuses on a fleet management problem that arises in container trucking industry. From the container transportation company perspective, the present and future operating costs to minimize can be divided in three components: the routing costs, the resource (i.e., driver and truck) assignment costs and the container repositioning costs (i.e., the costs of restoring a given container fleet distribution over the serviced territory, as requested by the shippers that own the containers). This real-world problem has been modeled as an integer programming problem. The proposed solution approach is based on the decomposition of this problem in three simpler sub-problems associate…
La tratta degli esseri umani. Nessi vischiosi fra vulnerabilità e violenza di prossimità
2021
La definizione di “tratta di esseri umani”, adottata dal Protocollo delle Nazioni Unite, descrive con chiarezza come la comunità internazionale abbia tratteggiato i concetti di vittima e di sfruttatore. Nonostante lo sforzo definitorio del Protocollo, questo articolo evidenzia una zona grigia nella relazione fra vulnerabilità e violenza di prossimità che rende possibile lo sfruttamento consensuale della vittima da parte del trafficante e la stessa difficoltà a delimitarne i contorni nelle aule di giustizia. L’articolo analizza il concetto di vulnerabilità, in relazione con quello di violenza di prossimità, e sviluppando in una specifica accezione di “vulnerabilità prossimale” che si rende e…
Baltic Journal of Psychology; Volume 18, Number 1&2
2018
Bērnības traumas, traumas simptomu saistība ar ēšanas uzvedību un negatīvu komunikāciju ģimenē par ēšanas uzvedību pusaudžiem 11 - 16 gadu vecumā
2022
Pētījuma mērķis ir noskaidrot, vai bērnībā piedzīvotajai traumatiskajai pieredzei, izjustajiem traumas simptomiem, negatīvajai komunikācijai par ēšanas uzvedību pastāv saistība ar ēšanas uzvedību. Papildus pētījumā tika apskatītas dzimumatšķirības un izmainītas ēšanas uzvedības biežumi. Pētījumā piedalījās 726 pusaudži (369 – meitenes, 344 – zēni, 13 – nenorādot dzimumu) vecumā no 11 līdz 16 gadiem, 5. un 9. klases skolēni. Darba ietvaros izmantotas šādas aptaujas: Bērnības traumas aptauja (Childhood Trauma Questionnaire, (CTQ), Fink et al., 1995). Bērnu traumas simptomu aptauja (Trauma symptom checklist for children (TSCC), Briere, 1995). Aptauja par attieksmi pret ēšanu – EAT-26 (Eating A…
Vardarbības pieredze bērnībā, traumas simptomi, paškaitējošā uzvedība un pašnāvības domas
2020
Pētījuma mērķis bija noskaidrot vai pastāv saistība starp bērnībā piedzīvotas vardarbības pieredzi, traumas simptomiem, paškaitējošo uzvedību un pašnāvības domām, kādas ir šo saistību dzimumatšķirības un vai pastāv atšķirības starp paškaitējošas uzvedības veidiem un biežumiem dažādos vecumposmos. Pētījumā piedalījās 184 respondenti (109 sievietes un 75 vīrieši) vecumā no 18 – 64 gadiem. Pētījumā tika izmantotas četras aptaujas - Bērnības traumas aptauja (Childhood Trauma Questionnaire, (CTQ), Fink, Bernstein, Handelsman, Foote & Lovejoy, 1995), “Traumas simptomu aptauja” (Trauma Symptom Inventory, Briere, 1995), „Pozitīvo un pašnāvības domu aptauja” (The Positive and Negative suicide ideati…
Agrīno neadaptivo shēmu, bērnības nelabvēlīgas pieredzes un depresijas simptomu saistība pacientiem ar diagnosticēto depresiju un psihiski veseliem c…
2016
Pētījuma mērķis bija izpētīt kādas saistības pastāv starp depresijas simptomu izteiktību, bērnībā pārciesto nelabvēlīgas pieredzi un agrīnajām neadaptīvām shēmām un noskaidrot, vai bērnības nelabvēlīgas pieredzes rādītāji paredz agrīno neadaptīvu shēmu radītājus un, savukārt, vai agrīno neadaptīvo shēmu rādītāji paredz depresijas simptomu izteiktību personām ar diagnosticētu depresiju un psihiski veselām personām. Pētījumā piedalījās 82 respondenti (visas sievietes), no kuriem 30 respondenti bija pacienti ar diagnosticēto depresiju un 52 psihiski veselas personas. Pētījumā tika izmantotas trīs aptaujas: Janga shēmu aptauja, Traumatisko pagātnes notikumu aptauja un Beka depresijas izpētes ap…
A Band Model of Cambium Development: Opportunities and Prospects
2021
More than 60% of tree phytomass is concentrated in stem wood, which is the result of periodic activity of the cambium. Nevertheless, there are few attempts to quantitatively describe cambium dynamics. In this study, we develop a state-of-the-art band model of cambium development, based on the kinetic heterogeneity of the cambial zone and the connectivity of the cell structure. The model describes seasonal cambium development based on an exponential function under climate forcing which can be effectively used to estimate the seasonal cell production for individual trees. It was shown that the model is able to simulate different cell production for fast-, middle- and slow-growing trees under …
Shell morphology of the unionid mussels (Anodonta anatina, Unio pictorum and U. tumidus) in relation to gender and trematode parasitism
2015
Freshwater mussels (Unionoida) show great variability in shell morphology which can be associated with differences in habitat, sex and/or parasite infection. Three unionid mussel species, (Anodonta anatina, Unio pictorum and Unio tumidus) were collected from two sites Lake Saravesi, (Laukaa) and Lake Kuivasjarvi, (Oulu), between May - October 2012. Intraspecific trends that were associated with the mussels’ sex and/or parasites infection were studied and observations were made on how sex and parasite infection could have a role in shells morphological characters/patterns. The study revealed a range of morphometric differences among and across populations, as well as, within and between spec…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…