Search results for "SIM"
showing 10 items of 10139 documents
Computing Difficulties for Deriving Poverty Indices from Some Functional Forms of Lorenz Curves
2014
We examine three families of classical one-parameter functional forms for estimating a Lorenz curve: the power form (Pareto, elementary form), the exponential form (Gupta, elementary form) and fractional form (Rohde). For the first time, we systematically study these functions not for their ability to be estimated but on the point of view of the possibility of deriving poverty indices, which implies first determining the headcount ratio (i.e., the percentage of poor). We show that computing difficulties have been largely underestimated. Two forms, the most simple ones, pose no problem: the elementary power and exponential forms. However, the Pareto functional form poses problem with a restr…
Generalized symmetries in nanostructure simulations
2009
The Impact of Financial Development and Macroeconomic Fundamentals on Nonperforming Loans among Emerging Countries: An Assessment Using the NARDL App…
2022
The relationship between financial development indicators and non-performing loans (NPLs) has garnered significant attention, especially in emerging countries. The puzzle of whether financial sector development increases or decreases Non-performing Loans (NPL)s has not been resolved to the satisfaction of the curious mind. This research attempts to answer the above question by studying the asymmetric and symmetric association between financial sector development and NPLs, by utilizing the novel non-linear autoregressive distribution lag (NARDL) and the linear autoregressive distribution lag (ARDL) approach. Moreover, to make the study inclusive, we have added a series of proxies to measure …
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety
2019
σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and pharmacologically evaluated. In structure-activity relationships studies, the σ1 receptor affinity and σ1:σ2 selectivity were correlated with the stereochemistry, the kind and substitution pattern of the O-heterocycle, and the substituents at the exocyclic amino moiety. cis-configured 2-benzopyran cis-11b bearing a methoxy group and a tertiary cyclohexylmethylamino moiety showed the highest σ1 affinity ( Ki = 1.9 nM) of this series of compounds. In…
Evaluation of asset replacement strategies considering economic cycles: lessons from the machinery rental business
2015
Contains fulltext : 144492.pdf (Publisher’s version ) (Open Access) In businesses with heavy capital investments, the effective management of assets is crucial, in particular in the fleet rental business where assets are the major source of revenues. One important question in this regard concerns the replacement of used assets and the purchase of new assets. Thus, the objective of this study is to evaluate performance effects of asset replacement strategies. In order to maximise net cash flow of a rental company for construction machinery, a range of scenarios investigating the timing and nature of policies for replacing the fleet are analysed. Simulation findings are then discussed to gene…
Modelling and assessing public health policies to counteract Italian measles outbreaks
2021
This study aims to understand, through explanatory research, the key factors that led to the 2017 measles outbreak in Italy, the causes of the low level of immunisation and the causes of possible cyclical phenomena of measles epidemics. This topic's comprehension has required a holistic approach, merging epidemiological aspects, socioeconomic aspects (including the evolution of mistrust in vaccinations, infodemy and fake news) and health law constraints. A specific SIR System Dynamics (SD) model was built to reproduce the relevant cause-and-effect relationships between social interactions, the public institutions behaviour and the measles outbreaks. SD results permit the assessment of the h…
Performance Management in Local Government: The Application of System Dynamics to Promote Data Use
2014
The purpose of this article is to demonstrate how system dynamics can be used to enrich performance management in local government, focusing specifically on how the development of conceptual and simulation system dynamic models can foster a shared view of the relevant system among stakeholders to overcome factors that limit data use. Responding to this purpose, we present a normative case study on how key drivers can be used to foster a shared view of the residential refuse collection system for supporting policy and process changes. A major finding from our research, however, is that performance management cannot overlook the broader forces of citizenship outcomes that impact the community.
Use of driving simulators for advanced driver assistance Systems evaluation in emergency situations
2012
Introducing advanced driver assistance systems in cars has numerous consequences, particularly on drivers' behavior and their interaction with the vehicle. The expected safety benefits of assistance systems can thus be jeopardized. In order to assess the actual safety benefits, driving simulators offer a safe and cheap alternative. This doctoral work relies on experiments carried out on driving simulators with different assistance systems. A first experimental part focuses on longitudinal control assistance: we studied drivers' familiarization with a Forward Collision Warning system in critical situations. A second experimental part focuses on lateral control assistance: we studied drivers'…
The Role of Small-Angle X-Ray Scattering and Molecular Simulations in 3D Structure Elucidation of a DNA Aptamer Against Lung Cancer
2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here we present a general optimization procedure for finding most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated aptamer LC-18t was developed. A three-dimensional shape of LC-18t was reported based on small-angle X-ray scattering (SAXS) experiments and m…