Search results for "SINGLE-PHOTON"
showing 10 items of 62 documents
THE SILICON PHOTOMULTIPLIER:AN IN-DEPTH ANALYSIS IN THE CONTINUOUS WAVE REGIME
2014
The Silicon Photomultiplier (SiPM) is a novel solid state photon counting detector consisting of a parallel array of avalanche photodiodes biased beyond their breakdown voltage. It has known a fast development in the last few years as a possible alternative to vacuum photomultiplier tubes (PMTs) and conventional avalanche photodiodes (APDs). Indeed, current research in photodetectors is directed toward an increasing miniaturization of the pixel size, thus both improving the spatial resolution and reducing the device dimensions. SiPMs show high photon detection efficiency in the visible and near infrared range, low power consumption, high gain, ruggedness, compact size, excellent single-phot…
Based on Compton Camera
2016
Compton Cameras have been proposed as an alternative to SPECT imaging with Gamma Camera, mainly due to factors such as the electronic collimation, which allows a bigger field of view and provides further information from the acquired events if compared to devices with mechanical collimation. By contrast, this involves a higher amount of data to be processed. In medical devices this leads to waiting times that are generally higher than desirable by the health-care professionals. In this work we have assessed the reconstruction of Compton images by making use of iterative and non-iterative techniques, and also evaluated its performances as a SPECT imaging technique.
D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status
1995
D2-dopamine receptors can be visualized in the human brain in vivo by Single Photon Emission Tomography (SPECT) and the radiolabeled benzamide [123I]IBZM. The present paper reviews the current status of this type of functional brain imaging with respect to basic methodological aspects, data analysis and quantification. The results from published clinical studies in different psychiatric patient populations and normal controls with [123I]IBZM are reviewed. [123I]IBZM-SPECT is a powerful tool for the investigation of D2-dopamine receptor status in psychiatric disorders, different types of drug treatment as well as therapeutic and side effects of pharmacologic agents. However, there still is a…
Somatostatin-receptor scintigraphy in Graves' disease: reproducibility and variance of orbital activity.
2000
Somatostatin-receptor (SSTR) scintigraphy using the single photon emission computed tomography (SPECT) technique allows the assessment of orbital inflammation in patients with Graves' disease. Previous studies showed differences in orbital octreotide uptake already 4 hr after injection. In this study, analysis of inter-/intra-observer variance and reproducibility in the evaluation of orbital SPECT images was performed. First, SPECT data of one representative female patient with clinically active Graves' ophthalmopathy (GO), obtained 4 hr after intravenous injection of 110 MBq 111In-pentetreotide and processed by filtered backprojection, were analyzed. Transverse SPECT images were reconstruc…
Arbitrary Phase Access for Stable Fiber Interferometers
2021
Well-controlled yet practical systems that give access to interference effects are critical for established and new functionalities in ultrafast signal processing, quantum photonics, optical coherence characterization, etc. Optical fiber systems constitute a central platform for such technologies. However, harnessing optical interference in a versatile and stable manner remains technologically costly and challenging. Here, degrees of freedom native to optical fibers, i.e., polarization and frequency, are used to demonstrate an easily deployable technique for the retrieval and stabilization of the relative phase in fiber interferometric systems. The scheme gives access (without intricate dev…
Photon events with missing energy at root s=183 to 189 GeV
2000
The production of single photons has been studied in the reaction e+e- -> gamma + invisible particles at centre-of-mass energies of 183 GeV and 189 GeV. A previously published analysis of events with multi-photon final states accompanied by missing energy has been updated with 189 GeV data. The data were collected with the DELPHI detector and correspond to integrated luminosities of about 51 pb^{-1} and 158 pb^{-1} at the two energies. The number of light neutrino families is measured to be 2.84 +/- 0.15(stat) +/- 0.14(syst). The absence of an excess of events beyond that expected from Standard Model processes is used to set limits on new physics as described by supersymmetric and compos…
Positional brain ischemia with MCA occlusion successfully treated with extra-intracranial bypass.
2010
408 Positional cerebral ischemia (PCI) is an extremely rare condition in which dramatic central nervous system deficits are triggered by standing in patients with severe stenosis or occlusion of the major brain-supplying blood vessels [1] . Because PCI is generally associated with orthostatic hypotension [2, 3] , a hemodynamic mechanism has been proposed [4] . However, PCI has been reported even in patients without orthostatic hypotension [1] . The treatment is medical, but surgery can be considered in refractory cases (endarterectomy for carotid artery stenosis or either highor low-flow extra-intracranial bypass – for carotid occlusion) [3] . We report a case of PCI associated with middle …
Preliminary assessment of the imaging capability of the YAP–(S)PET small animal scanner in neuroscience
2006
The new and fully engineered version of the YAP–(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4 � 4c m 2 of YAlO3:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axially � 4c m + transaxially. In PET mode, the volume resoluti…
Die nächste Generation „atypischer” Antipsychotika: Der Beitrag der Positronenemissionstomographie
2003
Almost fifteen years of research with Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have led to a profound understanding of the relationships between antipsychotic doses and plasma levels on the one hand and occupancy of (striatal) D 2 -like dopamine receptors on the other hand as well as with the associated clinical effects and side effects. Furthermore, with the development of clinically atypical" antipsychotics PET studies helped to generate hypotheses regarding the essential pharmacological properties of this heterogeneous class of drugs. Possible mechanisms of action include combined D 2 -/5-HT 2 antagonism, preferential mesolimbic binding, a…
Effects of an environment on a cavity-quantum-electrodynamics system controlled by bichromatic adiabatic passage
2012
International audience; We present a theoretical investigation of a cavity-QED system controlled by bichromatic adiabatic passage in a dissipative environment. We analyze the production of a controlled Fock state in the cavity by a traveling atom simultaneously coupled by a laser field, and the leakage of the corresponding photons from the cavity.